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Patent Searching and Data


Title:
PYRROLOIMIDAZOLE RING DERIVATIVE AND MEDICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/192714
Kind Code:
A1
Abstract:
The present invention relates to a pyrroloimidazole ring derivative and a medical application thereof, and particularly to a pyrroloimidazole ring derivative represented by general formula (I) or a stereoisomer thereof, a pharmaceutically acceptable salt thereof and a prodrug thereof, a pharmaceutical composition containing the derivative, and the medical use of the derivative in preparing a dipeptidyl peptidase IV (DPP-IV) inhibitor, wherein the definition of each substituent group in general formula (I) is the same as that in the specification.

Inventors:
FAN JIANG (CN)
ZHANG CHEN (CN)
PENG FEI (CN)
WU YE (CN)
FENG JIANCHUAN (CN)
WANG JIANMIN (CN)
ZHENG SUXIN (CN)
WEI YONGGANG (CN)
YE FEI (CN)
Application Number:
PCT/CN2015/080570
Publication Date:
December 23, 2015
Filing Date:
June 02, 2015
Export Citation:
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Assignee:
SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/4188; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P27/02; C07D487/14
Domestic Patent References:
WO2011103256A12011-08-25
WO2009153554A12009-12-23
Other References:
TESFAYE BIFTU ET AL.: "Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5 (4H)-yl]tetrahydro-2H-pyran-3-amine(23", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 19, 5 August 2013 (2013-08-05), pages 5361 - 5366, XP055094018, ISSN: 0960-0894x
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
北京三友知识产权代理有限公司 (CN)
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