Title:
PYRROLOIMIDAZOLE RING DERIVATIVE AND MEDICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/192714
Kind Code:
A1
Abstract:
The present invention relates to a pyrroloimidazole ring derivative and a medical application thereof, and particularly to a pyrroloimidazole ring derivative represented by general formula (I) or a stereoisomer thereof, a pharmaceutically acceptable salt thereof and a prodrug thereof, a pharmaceutical composition containing the derivative, and the medical use of the derivative in preparing a dipeptidyl peptidase IV (DPP-IV) inhibitor, wherein the definition of each substituent group in general formula (I) is the same as that in the specification.
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Inventors:
FAN JIANG (CN)
ZHANG CHEN (CN)
PENG FEI (CN)
WU YE (CN)
FENG JIANCHUAN (CN)
WANG JIANMIN (CN)
ZHENG SUXIN (CN)
WEI YONGGANG (CN)
YE FEI (CN)
ZHANG CHEN (CN)
PENG FEI (CN)
WU YE (CN)
FENG JIANCHUAN (CN)
WANG JIANMIN (CN)
ZHENG SUXIN (CN)
WEI YONGGANG (CN)
YE FEI (CN)
Application Number:
PCT/CN2015/080570
Publication Date:
December 23, 2015
Filing Date:
June 02, 2015
Export Citation:
Assignee:
SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/4188; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P27/02; C07D487/14
Domestic Patent References:
WO2011103256A1 | 2011-08-25 | |||
WO2009153554A1 | 2009-12-23 |
Other References:
TESFAYE BIFTU ET AL.: "Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5 (4H)-yl]tetrahydro-2H-pyran-3-amine(23", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 19, 5 August 2013 (2013-08-05), pages 5361 - 5366, XP055094018, ISSN: 0960-0894x
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
北京三友知识产权代理有限公司 (CN)
北京三友知识产权代理有限公司 (CN)
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