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Patent Searching and Data


Title:
PYRUVATE DEHYDROGENASE KINASE INHIBITOR AND APPLICATION THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/161524
Kind Code:
A1
Abstract:
Provided is a pyruvate dehydrogenase kinase inhibitor and an application therefor. Specifically provided is a compound Ra-S-S-Rb of formula X or a pharmaceutically acceptable salt thereof, the compound having excellent inhibition of pyruvate dehydrogenase kinase activity and anti-tumour effects. Also provided is a pharmaceutical composition containing said compound and applications for inhibiting pyruvate dehydrogenase kinase activity and resisting tumours.

Inventors:
LI JIAN (CN)
HUANG MIN (CN)
GENG MEIYU (CN)
LIU YIFU (CN)
TANG SHUAI (CN)
LAN XIAOJING (CN)
ZHU JIN (CN)
Application Number:
PCT/CN2016/077137
Publication Date:
September 28, 2017
Filing Date:
March 23, 2016
Export Citation:
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Assignee:
UNIV EAST CHINA SCIENCE & TECH (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D295/20; A61K31/428; A61K31/535; A61P35/00; C07D277/78
Foreign References:
JPH0363258A1991-03-19
Other References:
KULKARNI RHUSHIKESH A. ET AL.: "Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase", CHEMMEDCHEM, vol. 8, 19 July 2013 (2013-07-19), pages 1561 - 1568, XP055422208
COFFEY KELLY ET AL.: "Characterisation of a tip60 specific inhibitor, NU9056, in prostate cancer", PLOS ONE, vol. 7, 31 December 2012 (2012-12-31), pages e45539, XP055422220
MENG, DONG ET AL.: "Quality control of medical intermediate DM", APPLIED CHEMICAL INDUSTRY, vol. 42, no. 9, 30 September 2013 (2013-09-30), pages 1618, 1619 and 1623
JIAN, JIYONG ET AL.: "Research progresses on pyruvate dehydrogenase kinases", BASIC & CLINICAL MEDICINE, vol. 28, no. 11, 30 November 2008 (2008-11-30), pages 1212 - 1215
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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