Title:
PYRUVATE DEHYDROGENASE KINASE INHIBITOR AND APPLICATION THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/161524
Kind Code:
A1
Abstract:
Provided is a pyruvate dehydrogenase kinase inhibitor and an application therefor. Specifically provided is a compound Ra-S-S-Rb of formula X or a pharmaceutically acceptable salt thereof, the compound having excellent inhibition of pyruvate dehydrogenase kinase activity and anti-tumour effects. Also provided is a pharmaceutical composition containing said compound and applications for inhibiting pyruvate dehydrogenase kinase activity and resisting tumours.
More Like This:
Inventors:
LI JIAN (CN)
HUANG MIN (CN)
GENG MEIYU (CN)
LIU YIFU (CN)
TANG SHUAI (CN)
LAN XIAOJING (CN)
ZHU JIN (CN)
HUANG MIN (CN)
GENG MEIYU (CN)
LIU YIFU (CN)
TANG SHUAI (CN)
LAN XIAOJING (CN)
ZHU JIN (CN)
Application Number:
PCT/CN2016/077137
Publication Date:
September 28, 2017
Filing Date:
March 23, 2016
Export Citation:
Assignee:
UNIV EAST CHINA SCIENCE & TECH (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D295/20; A61K31/428; A61K31/535; A61P35/00; C07D277/78
Foreign References:
JPH0363258A | 1991-03-19 |
Other References:
KULKARNI RHUSHIKESH A. ET AL.: "Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase", CHEMMEDCHEM, vol. 8, 19 July 2013 (2013-07-19), pages 1561 - 1568, XP055422208
COFFEY KELLY ET AL.: "Characterisation of a tip60 specific inhibitor, NU9056, in prostate cancer", PLOS ONE, vol. 7, 31 December 2012 (2012-12-31), pages e45539, XP055422220
MENG, DONG ET AL.: "Quality control of medical intermediate DM", APPLIED CHEMICAL INDUSTRY, vol. 42, no. 9, 30 September 2013 (2013-09-30), pages 1618, 1619 and 1623
JIAN, JIYONG ET AL.: "Research progresses on pyruvate dehydrogenase kinases", BASIC & CLINICAL MEDICINE, vol. 28, no. 11, 30 November 2008 (2008-11-30), pages 1212 - 1215
COFFEY KELLY ET AL.: "Characterisation of a tip60 specific inhibitor, NU9056, in prostate cancer", PLOS ONE, vol. 7, 31 December 2012 (2012-12-31), pages e45539, XP055422220
MENG, DONG ET AL.: "Quality control of medical intermediate DM", APPLIED CHEMICAL INDUSTRY, vol. 42, no. 9, 30 September 2013 (2013-09-30), pages 1618, 1619 and 1623
JIAN, JIYONG ET AL.: "Research progresses on pyruvate dehydrogenase kinases", BASIC & CLINICAL MEDICINE, vol. 28, no. 11, 30 November 2008 (2008-11-30), pages 1212 - 1215
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF:
Previous Patent: PHOTOGRAPHY FOCUSING METHOD, DEVICE, AND APPARATUS FOR TERMINAL
Next Patent: ELECTRONIC DEVICE
Next Patent: ELECTRONIC DEVICE