Title:
QUANTIFYING CELL MIGRATION IN WOUND HEALING ASSAYS
Document Type and Number:
WIPO Patent Application WO/2010/036913
Kind Code:
A3
Abstract:
Methods and systems that can be used for quantifying cell migration in wound healing assays can include: an optically transmissive substrate; a covering removably attached to the optically transmissive substrate such that the covering extends across a first portion of a face of the optically transmissive substrate and a second portion of the face of the optically transmissive substrate is free of the covering; and a layer of material having optical properties that are different than the optical properties of the optically transmissive substrate, the layer of material applied to the face of the optically transmissive substrate.
Inventors:
IRIMIA DANIEL (US)
NERY FLAVIA (US)
BREAKFIELD XANDRA (US)
TONER MEHMET (US)
NERY FLAVIA (US)
BREAKFIELD XANDRA (US)
TONER MEHMET (US)
Application Number:
PCT/US2009/058410
Publication Date:
July 08, 2010
Filing Date:
September 25, 2009
Export Citation:
Assignee:
GEN HOSPITAL CORP (US)
IRIMIA DANIEL (US)
NERY FLAVIA (US)
BREAKFIELD XANDRA (US)
TONER MEHMET (US)
IRIMIA DANIEL (US)
NERY FLAVIA (US)
BREAKFIELD XANDRA (US)
TONER MEHMET (US)
International Classes:
C12Q1/02; G01N33/48
Foreign References:
| US7018838B2 | 2006-03-28 |
Other References:
FU-QIANG NIE ET AL.: "On-chip cell migration assay using microfluidic channels", BIOMATERIALS, vol. 28, 2007, pages 4017 - 4022
TANIA BETANCOURT ET AL.: "Micro- and nanofabrication methods in nanotechnological medical and pharmaceutical devices", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 1, no. 4, 2006, pages 483 - 495
JOE TIEN ET AL.: "Fabrication of aligned microstructures with a single elastomeric stamp", PNAS, vol. 99, no. 4, 19 February 2002 (2002-02-19), pages 1758 - 1762
HEATHER LAUDER ET AL.: "Quantification of the repair process involved in the repair of a cell monolayer using an in vitro model of mechanical injury", ANGIOGENESIS, vol. 2, 1998, pages 67 - 80
TANIA BETANCOURT ET AL.: "Micro- and nanofabrication methods in nanotechnological medical and pharmaceutical devices", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 1, no. 4, 2006, pages 483 - 495
JOE TIEN ET AL.: "Fabrication of aligned microstructures with a single elastomeric stamp", PNAS, vol. 99, no. 4, 19 February 2002 (2002-02-19), pages 1758 - 1762
HEATHER LAUDER ET AL.: "Quantification of the repair process involved in the repair of a cell monolayer using an in vitro model of mechanical injury", ANGIOGENESIS, vol. 2, 1998, pages 67 - 80
Attorney, Agent or Firm:
DEAN, PH.D., J.D., Sean M. et al. (P.O. Box 1022Minneapolis, Minnesota, US)
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