Title:
QUANTITATIVE ACETAMINOPHEN ANALYTICS
Document Type and Number:
WIPO Patent Application WO/2019/137890
Kind Code:
A1
Abstract:
The aim of the invention is to provide a method for quantitatively determining the amount of acetaminophen in a sample with greater precision, greater sensitivity and fewer interactions and less spectral and chemical interference with other compounds contained in the sample. This aim is achieved, according to the invention, by means of a method, in which acetominophen is hydrolyzed and the resulting p-aminophenol is reacted with a compound of general formula (III) in the presence of an oxidant, R1 and R2 being selected independently from each other from among H, -CH3 and -OCH3, R3 being -C2H5 and R4 being a C1-4-alkyl moiety having a terminal sulfonate group, with the stipulation that at least one of R1 and R2 is -OCH3 and/or R4 additionally has at least one OH substituent, and subsequently the amount of the compound of general formula (IV) in the reaction mixture is photometrically determined.
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Inventors:
GRIMMLER MATTHIAS (DE)
THÖNGES DETLEF (DE)
SCHU PIA (DE)
MENZENBACH CAROLIN (DE)
KRECKEL LAURA (DE)
THÖNGES DETLEF (DE)
SCHU PIA (DE)
MENZENBACH CAROLIN (DE)
KRECKEL LAURA (DE)
Application Number:
PCT/EP2019/050291
Publication Date:
July 18, 2019
Filing Date:
January 08, 2019
Export Citation:
Assignee:
DIASYS DIAGNOSTIC SYSTEMS GMBH (DE)
International Classes:
G01N33/94; C12Q1/34
Foreign References:
| EP0750197A2 | 1996-12-27 | |||
| US8715952B2 | 2014-05-06 | |||
| EP0750197A2 | 1996-12-27 |
Other References:
JALIL TAVAKOLI AFSHARI ET AL: "Rapid spectrophotometric method for the quantitation of acetaminophen in serum", ANALYTICA CHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 443, 1 January 2001 (2001-01-01), pages 165 - 169, XP008146313, ISSN: 0003-2670
MORRIS H C ET AL: "Development and validation of an automated enzyme assay for paracetamol (acetaminophen)", CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 187, no. 2, 28 February 1990 (1990-02-28), pages 95 - 104, XP023398129, ISSN: 0009-8981, [retrieved on 19900228], DOI: 10.1016/0009-8981(90)90335-P
HAMMOND P M ET AL: "Development of an enzyme-based assay for acetaminophen", ANALYTICAL BIOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 143, no. 1, 15 November 1984 (1984-11-15), pages 152 - 157, XP024820133, ISSN: 0003-2697, [retrieved on 19841115], DOI: 10.1016/0003-2697(84)90570-0
MORRIS H C ET AL: "Development and validation of an automated enzyme assay for paracetamol (acetaminophen)", CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 187, no. 2, 28 February 1990 (1990-02-28), pages 95 - 104, XP023398129, ISSN: 0009-8981, [retrieved on 19900228], DOI: 10.1016/0009-8981(90)90335-P
HAMMOND P M ET AL: "Development of an enzyme-based assay for acetaminophen", ANALYTICAL BIOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 143, no. 1, 15 November 1984 (1984-11-15), pages 152 - 157, XP024820133, ISSN: 0003-2697, [retrieved on 19841115], DOI: 10.1016/0003-2697(84)90570-0
Attorney, Agent or Firm:
HIORT, Jan et al. (DE)
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