Title:
QUANTITATIVE ASSESSMENT INDEX FOR FETAL GROWTH RESTRICTION
Document Type and Number:
WIPO Patent Application WO/2021/167098
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an assessment and diagnosis method for predicting neurodevelopmental disorders at an early stage, determining the optimal treatment policy, and assessing the effect of intervention treatment in newborns at an early stage, by appropriately and accurately diagnosing, with high sensitivity, perinatal brain disorders (for example, neurodevelopmental disorders) in newborns associated with fetal growth restriction. According to the present invention, provided is a method for determining, at an early stage, perinatal brain disorders of newborns caused by fetal growth restriction, the method involving (a) a process for assessing the expression levels of one or more proteins selected from the group consisting of α-2-macroglobulin (A2m), OX-2 membrane glycoprotein (Cd200), polyubiquitin-B (Ubb), neuroserpin (Serpini1), ubiquitin thioesterase OTUB1 (Otub1), and ubiquitin-like modifier activating enzyme 1 (Uba1) in a body fluid sample obtained from a subject, in comparison with the expression levels in a control body fluid.
Inventors:
SATO YOSHIAKI (JP)
SHIMIZU SHINOBU (JP)
HAYAKAWA MASAHIRO (JP)
KITASE YUMA (JP)
ONODA ATSUTO (JP)
TSUJI MASAHIRO (JP)
DEZAWA MARI (JP)
SHIMIZU SHINOBU (JP)
HAYAKAWA MASAHIRO (JP)
KITASE YUMA (JP)
ONODA ATSUTO (JP)
TSUJI MASAHIRO (JP)
DEZAWA MARI (JP)
Application Number:
PCT/JP2021/006475
Publication Date:
August 26, 2021
Filing Date:
February 19, 2021
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
International Classes:
G01N37/00; C07K14/705; C07K14/81; C07K16/00; C07K17/00; C12N9/16; G01N27/62; G01N30/72; G01N33/53; G01N33/573
Domestic Patent References:
| WO2018235878A1 | 2018-12-27 |
Foreign References:
| JP2020502533A | 2020-01-23 | |||
| JP2017516119A | 2017-06-15 | |||
| JP2015533504A | 2015-11-26 | |||
| US20130295679A1 | 2013-11-07 |
Other References:
SHOUJI, HIROMICHI ET AL.: "Review of analysis of urinary metabolome of intrauterine growth restricted mice", THE JOURNAL OF THE JAPAN PEDIATRIC SOCIETY, vol. 120, no. 2, 1 February 2016 (2016-02-01), pages 238
RUIS-GONZALEZ MARIA D., MARIA D. CANETE, JOSÉ L. GOMEZ-CHAPARRO, NIEVES ABRIL, RAMON CANETE, JUAN LOPEZ-BAREA: "Alterations of protein expression in serum of infants with intrauterine growth restriction and different gestational ages", JOURNAL OF PROTEOMICS, vol. 119, 24 April 2015 (2015-04-24), pages 169 - 182, XP055856116, DOI: 10.1016/j.jprot.2015.02.003
ONODA, ATSUTO ET AL.: "Comprehensive analysis of protein in cerebrospinal fluid of rat in fetal growth retardation model", THE 55TH JOURNAL OF JAPAN SOCIETY OF PERINATAL AND NEONATAL MEDICINE, 2019, pages 313
CHEN RONG-JUN ET AL.: "Effects of intrauterine growth restriction on gene expression in small intestine of piglets", ANIMAL HUSBANDRY AND FEED SCIENCE, vol. 1, no. 4-5, 2009, pages 41 - 46
HAYYAKAWA, MASAHIRO ET AL.: "Research on histological and molecular biological changes in central nerves of rat in intrauterine fetal growth restriction model", JOURNAL OF JAPAN SOCIETY OF PERINATAL AND NEONATAL MEDICINE, vol. 44, December 2008 (2008-12-01), pages 20
KARAMESSINIS PANAGIOTIS M., ARIADNE MALAMITSI-PUCHNER, THEODORA BOUTSIKOU, MANOUSOS MAKRIDAKIS, KONSTANTINOS VOUGAS, MICHAEL FOUNT: "Marked defects in the expression and glycosylation of alpha2-HS glycoprotein/fetuin-A in plasma from neonates with intrauterine growth restriction: proteomics screening and potential clinical implications", MOLECULAR & CELLULAR PROTEOMICS : MCP, vol. 7, no. 3, 7 December 2007 (2007-12-07), pages 591 - 599, XP055856114, DOI: 10.1074/mcp.M700422-MCP200
GACCIOLI FRANCESCA; AYE IRVING L.M.H.; SOVIO ULLA; CHARNOCK-JONES D. STEPHEN; SMITH GORDON C.S.: "Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 218, no. 2, 22 December 2017 (2017-12-22), US , XP086376106, ISSN: 0002-9378, DOI: 10.1016/j.ajog.2017.12.002
STRINI} TOMISLAV, BUKOVI} DAMIR, RADI} ANTE, UMILIN LADA [, HAUPTMAN DINKO, SOVI} TOMISLAV: "Comparison of Fetal Plasma Cortisol Level between Eutrophic and Hypotrophic Newborns", COLLEGIUM ANTROPOLOGICUM, vol. 29, no. 2, 1 January 2005 (2005-01-01), pages 739 - 741, XP055856111
KINJO, TADAMUNE ET AL.: "Research on etiology and pathology of fetal growth restriction (FGR) understood from abnormality in innate immune system - about relationship between vasculitis and human FGR development", ANNUAL REPORT OF FUKUOKA CHILDREN'S HOSPITAL, vol. 38, December 2017 (2017-12-01), pages 209 - 210
HUANG SHIMENG; LI NA; LIU CONG; LI TIANTIAN; WANG WEI; JIANG LILI; LI ZHEN; HAN DANDAN; TAO SHIYU; WANG JUNJUN: "Characteristics of the gut microbiota colonization, inflammatory profile, and plasma metabolome in intrauterine growth restricted piglets during the first 12 hours after birth", THE JOURNAL OF MICROBIOLOGY, THE MICROBIOLOGICAL SOCIETY OF KOREA // HAN-GUG MISAENGMUL HAG-HOE, KR, vol. 57, no. 9, 11 June 2019 (2019-06-11), KR , pages 748 - 758, XP036872817, ISSN: 1225-8873, DOI: 10.1007/s12275-019-8690-x
DESSÌ ANGELICA, MURGIA ANTONIO, AGOSTINO ROCCO, PATTUMELLI MARIA, SCHIRRU ANDREA, SCANO PAOLA, FANOS VASSILIOS, CABONI PIERLUIGI: "Exploring the Role of Different Neonatal Nutrition Regimens during the First Week of Life by Urinary GC-MS Metabolomics", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 17, no. 2, 22 February 2016 (2016-02-22), XP055856109, DOI: 10.3390/ijms17020265
HASHIMOTO, MAKOTO ET AL.: "Relationship between short term growth and insulin-like growth factor at three weeks and five weeks old in premature infant", JOURNAL OF JAPAN SOCIETY FOR NEONATAL HEALTH AND DEVELOPMENT, vol. 31, no. 1, 15 February 2019 (2019-02-15), pages 83 - 89
SHARP ANDREW; JACKSON RICHARD; CORNFORTH CHRISTINE; HARROLD JANE; TURNER MARK A.; KENNY LOUISE; BAKER PHILIP N.; JOHNSTONE EDWARD : "A prediction model for short-term neonatal outcomes in severe early-onset fetal growth restriction", EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, ELSEVIER IRELAND LTD., IE, vol. 241, 16 August 2019 (2019-08-16), IE , pages 109 - 118, XP085833816, ISSN: 0301-2115, DOI: 10.1016/j.ejogrb.2019.08.007
TSUGE MITSURU; HIDA AKIRA I.; MINEMATSU TOSHIO; HONDA NAOTOSHI; OSHIRO YUMI; YOKOYAMA MIKIFUMI; KONDO YOICHI: "Prospective Cohort Study of Congenital Cytomegalovirus Infection during Pregnancy with Fetal Growth Restriction: Serologic Analysis and Placental Pathology", JOURNAL OF PEDIATRICS., MOSBY-YEAR BOOK, ST. LOUIS, MO, US, vol. 206, 6 November 2018 (2018-11-06), US , pages 42, XP085610843, ISSN: 0022-3476, DOI: 10.1016/j.jpeds.2018.10.003
ONODA, ATSUTO ET AL.: "Analysis of proteome in cerebrospinal fluid in perinatal brain damage caused by fetal growth restriction", PHARMACEUTICAL HEALTH SCIENCE ENVIRONMENTAL TOXICOLOGY, vol. 2019, 17 August 2019 (2019-08-17), pages 151
RUIS-GONZALEZ MARIA D., MARIA D. CANETE, JOSÉ L. GOMEZ-CHAPARRO, NIEVES ABRIL, RAMON CANETE, JUAN LOPEZ-BAREA: "Alterations of protein expression in serum of infants with intrauterine growth restriction and different gestational ages", JOURNAL OF PROTEOMICS, vol. 119, 24 April 2015 (2015-04-24), pages 169 - 182, XP055856116, DOI: 10.1016/j.jprot.2015.02.003
ONODA, ATSUTO ET AL.: "Comprehensive analysis of protein in cerebrospinal fluid of rat in fetal growth retardation model", THE 55TH JOURNAL OF JAPAN SOCIETY OF PERINATAL AND NEONATAL MEDICINE, 2019, pages 313
CHEN RONG-JUN ET AL.: "Effects of intrauterine growth restriction on gene expression in small intestine of piglets", ANIMAL HUSBANDRY AND FEED SCIENCE, vol. 1, no. 4-5, 2009, pages 41 - 46
HAYYAKAWA, MASAHIRO ET AL.: "Research on histological and molecular biological changes in central nerves of rat in intrauterine fetal growth restriction model", JOURNAL OF JAPAN SOCIETY OF PERINATAL AND NEONATAL MEDICINE, vol. 44, December 2008 (2008-12-01), pages 20
KARAMESSINIS PANAGIOTIS M., ARIADNE MALAMITSI-PUCHNER, THEODORA BOUTSIKOU, MANOUSOS MAKRIDAKIS, KONSTANTINOS VOUGAS, MICHAEL FOUNT: "Marked defects in the expression and glycosylation of alpha2-HS glycoprotein/fetuin-A in plasma from neonates with intrauterine growth restriction: proteomics screening and potential clinical implications", MOLECULAR & CELLULAR PROTEOMICS : MCP, vol. 7, no. 3, 7 December 2007 (2007-12-07), pages 591 - 599, XP055856114, DOI: 10.1074/mcp.M700422-MCP200
GACCIOLI FRANCESCA; AYE IRVING L.M.H.; SOVIO ULLA; CHARNOCK-JONES D. STEPHEN; SMITH GORDON C.S.: "Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 218, no. 2, 22 December 2017 (2017-12-22), US , XP086376106, ISSN: 0002-9378, DOI: 10.1016/j.ajog.2017.12.002
STRINI} TOMISLAV, BUKOVI} DAMIR, RADI} ANTE, UMILIN LADA [, HAUPTMAN DINKO, SOVI} TOMISLAV: "Comparison of Fetal Plasma Cortisol Level between Eutrophic and Hypotrophic Newborns", COLLEGIUM ANTROPOLOGICUM, vol. 29, no. 2, 1 January 2005 (2005-01-01), pages 739 - 741, XP055856111
KINJO, TADAMUNE ET AL.: "Research on etiology and pathology of fetal growth restriction (FGR) understood from abnormality in innate immune system - about relationship between vasculitis and human FGR development", ANNUAL REPORT OF FUKUOKA CHILDREN'S HOSPITAL, vol. 38, December 2017 (2017-12-01), pages 209 - 210
HUANG SHIMENG; LI NA; LIU CONG; LI TIANTIAN; WANG WEI; JIANG LILI; LI ZHEN; HAN DANDAN; TAO SHIYU; WANG JUNJUN: "Characteristics of the gut microbiota colonization, inflammatory profile, and plasma metabolome in intrauterine growth restricted piglets during the first 12 hours after birth", THE JOURNAL OF MICROBIOLOGY, THE MICROBIOLOGICAL SOCIETY OF KOREA // HAN-GUG MISAENGMUL HAG-HOE, KR, vol. 57, no. 9, 11 June 2019 (2019-06-11), KR , pages 748 - 758, XP036872817, ISSN: 1225-8873, DOI: 10.1007/s12275-019-8690-x
DESSÌ ANGELICA, MURGIA ANTONIO, AGOSTINO ROCCO, PATTUMELLI MARIA, SCHIRRU ANDREA, SCANO PAOLA, FANOS VASSILIOS, CABONI PIERLUIGI: "Exploring the Role of Different Neonatal Nutrition Regimens during the First Week of Life by Urinary GC-MS Metabolomics", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 17, no. 2, 22 February 2016 (2016-02-22), XP055856109, DOI: 10.3390/ijms17020265
HASHIMOTO, MAKOTO ET AL.: "Relationship between short term growth and insulin-like growth factor at three weeks and five weeks old in premature infant", JOURNAL OF JAPAN SOCIETY FOR NEONATAL HEALTH AND DEVELOPMENT, vol. 31, no. 1, 15 February 2019 (2019-02-15), pages 83 - 89
SHARP ANDREW; JACKSON RICHARD; CORNFORTH CHRISTINE; HARROLD JANE; TURNER MARK A.; KENNY LOUISE; BAKER PHILIP N.; JOHNSTONE EDWARD : "A prediction model for short-term neonatal outcomes in severe early-onset fetal growth restriction", EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, ELSEVIER IRELAND LTD., IE, vol. 241, 16 August 2019 (2019-08-16), IE , pages 109 - 118, XP085833816, ISSN: 0301-2115, DOI: 10.1016/j.ejogrb.2019.08.007
TSUGE MITSURU; HIDA AKIRA I.; MINEMATSU TOSHIO; HONDA NAOTOSHI; OSHIRO YUMI; YOKOYAMA MIKIFUMI; KONDO YOICHI: "Prospective Cohort Study of Congenital Cytomegalovirus Infection during Pregnancy with Fetal Growth Restriction: Serologic Analysis and Placental Pathology", JOURNAL OF PEDIATRICS., MOSBY-YEAR BOOK, ST. LOUIS, MO, US, vol. 206, 6 November 2018 (2018-11-06), US , pages 42, XP085610843, ISSN: 0022-3476, DOI: 10.1016/j.jpeds.2018.10.003
ONODA, ATSUTO ET AL.: "Analysis of proteome in cerebrospinal fluid in perinatal brain damage caused by fetal growth restriction", PHARMACEUTICAL HEALTH SCIENCE ENVIRONMENTAL TOXICOLOGY, vol. 2019, 17 August 2019 (2019-08-17), pages 151
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Download PDF:
Previous Patent: METHOD FOR IMPROVING AGING BY ACTIVATING ARRECTOR PILI MUSCLE CELLS
Next Patent: SPRINKLING DEVICE
Next Patent: SPRINKLING DEVICE