QUANTITATIVE IN VITRO BONE INDUCTION ASSAY

Title:

QUANTITATIVE IN VITRO BONE INDUCTION ASSAY

Document Type and Number:

WIPO Patent Application WO2003004990

Kind Code:

A3

Abstract:

An in vitro assay for quantifying the osteogenic capacity of bone implants involves in vitro isolation and quantitation of specific osteogenic factors. The method disclosed permits direct measurement of the osteogenic capacity of an implant to allow greater predictability of the degree to which new bone will grow in a given area. The method eliminates the need to practice the traditional technique of implanting material into a test animal and subsequently sacrificing the animal to assess bone growth associated with the implant. Since the present method does not involve animal testing, it is an extremely reproducible, rapid, and accurate method for predicting whether an implanted composition or material will induce bone growth without the need for in v ivo assays.

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Inventors:

WIRONEN JOHN F
JAW REBECCA

Application Number:

PCT/US2002/021026

Publication Date:

November 27, 2003

Filing Date:

July 03, 2002

Export Citation:

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Assignee:

REGENERATION TECH INC (US)

International Classes:

A61L27/36; A61L27/54; G01N33/74; (IPC1-7): G01N33/48; C12Q1/00

Foreign References:

US6189537B1	2001-02-20
US5208219A	1993-05-04
US5854207A	1998-12-29
US6333312B1	2001-12-25

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