Title:
QUANTUM DOT BEAD HAVING MULTIFUNCTIONAL LIGAND, AND TARGET ANTIGEN DETECTION METHOD AND BIO-DIAGNOSTIC APPARATUS USING SAME
Document Type and Number:
WIPO Patent Application WO/2019/231109
Kind Code:
A1
Abstract:
In one aspect, the present disclosure relates to a quantum dot bead comprising a multifunctional ligand having a first conjugated material and a second antibody, and an immunochromatographic detection method for a target antigen in a biological sample, comprising forming multiple bonds with a quantum dot having a second conjugated material. In addition, the present disclosure has the effect of remarkably amplifying the detection intensity and significantly improving the detection sensitivity without a separate washing step, and thus enables the detection and diagnosis of physiological substances in a biological sample even in an actual product, and may be used to provide a product with excellent price competitiveness.
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Inventors:
JUNG HEUNG SU (KR)
SHIN SUNG YOUNG (KR)
KIM HYUN SOO (KR)
PARK SANG HYUN (KR)
LEE JI YOUNG (KR)
SHIN SUNG YOUNG (KR)
KIM HYUN SOO (KR)
PARK SANG HYUN (KR)
LEE JI YOUNG (KR)
Application Number:
PCT/KR2019/004774
Publication Date:
December 05, 2019
Filing Date:
April 19, 2019
Export Citation:
Assignee:
ZEUS CO LTD (KR)
International Classes:
G01N33/543; B01L3/00; G01N33/558
Foreign References:
| US20100068727A1 | 2010-03-18 |
Other References:
LI, XUE %: "Rapid and quantitative detection of prostate specific antigen with a quantum dot nanobeads-based immunochromatography test strip", ACS APPLIED MATERIALS & INTERFACES, June 2014 (2014-06-01), pages 6406 - 6414, XP055648466
ZHANG, PENGFEI: "Simple and sensitive detection of HBsAg by using a quantum dots nanobeads based dot-blot immunoassay", THERANOSTICS, 3 April 2014 (2014-04-03), pages 307 - 315, XP055648478
VASHIST ET AL.: "Review of quantum dot technologies for cancer detection and treatmen t", AZOJONO JOURNAL OF NANOTECHNOLOGY, vol. 2, 2006, pages 1 - 14
SUSUMU, KIMIHIRO: "Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, 2007, pages 13987 - 13996, XP008146644, DOI: 10.1021/ja0749744
ZHANG, PENGFEI: "Simple and sensitive detection of HBsAg by using a quantum dots nanobeads based dot-blot immunoassay", THERANOSTICS, 3 April 2014 (2014-04-03), pages 307 - 315, XP055648478
VASHIST ET AL.: "Review of quantum dot technologies for cancer detection and treatmen t", AZOJONO JOURNAL OF NANOTECHNOLOGY, vol. 2, 2006, pages 1 - 14
SUSUMU, KIMIHIRO: "Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, 2007, pages 13987 - 13996, XP008146644, DOI: 10.1021/ja0749744
Attorney, Agent or Firm:
CHANG, Duck Soon et al. (KR)
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