Title:
QUANTUM DOT MODIFIED PROTEIN VACCINE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/274298
Kind Code:
A1
Abstract:
A quantum dot modified protein vaccine and a preparation method therefor and an application thereof, relating to the field of nanomaterials and biomedicines. Raw materials of the quantum dot modified protein vaccine comprise quantum dot particles and antigen protein, the surfaces of the quantum dot particles comprise biocompatible functional groups, and the antigen protein and the functional groups act to enable the protein to be wound on the surfaces of the quantum dot particles under the action of non-covalent bonds. The antigen protein is modified by means of the quantum dots, a spatial conformation of the antigen protein can be changed, the immunogenicity of normal protein is remarkably enhanced due to these conformation modifications, dysfunction of immunosuppressive protein on cancer cells is caused, and the specific recognition probability can be enhanced. Such a quantum dot modified protein vaccine can greatly improve the immunogenicity of protein, and thus has better immune activation characteristics. The quantum dot modified protein vaccine is simple in preparation method, and is mild in operation conditions. The obtained quantum dot modified protein vaccine can be applied to personalized immunotherapy of cancers.
Inventors:
QU SONGNAN (CN)
TANG ZIKANG (CN)
LIANG TAO (CN)
DENG CHUXIA (CN)
LEI HAIPENG (CN)
TANG ZIKANG (CN)
LIANG TAO (CN)
DENG CHUXIA (CN)
LEI HAIPENG (CN)
Application Number:
PCT/CN2022/102376
Publication Date:
January 05, 2023
Filing Date:
June 29, 2022
Export Citation:
Assignee:
UNIV MACAU (CN)
International Classes:
A61K39/00; A61K39/385; A61P35/00; C01B32/15; C07K1/107
Foreign References:
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| CN113476594A | 2021-10-08 | |||
| CN113440607A | 2021-09-28 | |||
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| CN108030919A | 2018-05-15 | |||
| CN103013490A | 2013-04-03 | |||
| CN107583059A | 2018-01-16 | |||
| CN105727319A | 2016-07-06 |
Other References:
LIANG TAO, JOSH HAIPENG LEI, GUO SEN, GAO HANLU, ZHU LIPENG, ZHOU YINNING, LIU YOU-CHENG, XI LONG, TONG HAIBO, LIU ENSHAN, ZHANG B: "Cancer Immunotherapy Based on Carbon-Quantum-Dots", RESEARCH SQUARE, 28 April 2021 (2021-04-28), XP093018989, DOI: 10.21203/rs.3.rs-457550/v2
CHENG JIA, XU YULIANG, ZHOU DONG, LIU KANGPING, GENG NA, LU JIANWEI, LIU YONGXIA, LIU JIANZHU: "Novel carbon quantum dots can serve as an excellent adjuvant for the gp85 protein vaccine against avian leukosis virus subgroup J in chickens", POULTRY SCIENCE, OXFORD UNIVERSITY PRESS, OXFORD, vol. 98, no. 11, 1 November 2019 (2019-11-01), Oxford , pages 5315 - 5320, XP093018986, ISSN: 0032-5791, DOI: 10.3382/ps/pez313
LIU, F. ET AL.: "Quantum dot-pulsed dendritic cell vaccines plus macrophage polarization for amplified cancer immunotherapy.", BIOMATERIALS., vol. 242, 29 February 2020 (2020-02-29), XP086090537, DOI: 10.1016/j.biomaterials.2020.119928
CHENG JIA, XU YULIANG, ZHOU DONG, LIU KANGPING, GENG NA, LU JIANWEI, LIU YONGXIA, LIU JIANZHU: "Novel carbon quantum dots can serve as an excellent adjuvant for the gp85 protein vaccine against avian leukosis virus subgroup J in chickens", POULTRY SCIENCE, OXFORD UNIVERSITY PRESS, OXFORD, vol. 98, no. 11, 1 November 2019 (2019-11-01), Oxford , pages 5315 - 5320, XP093018986, ISSN: 0032-5791, DOI: 10.3382/ps/pez313
LIU, F. ET AL.: "Quantum dot-pulsed dendritic cell vaccines plus macrophage polarization for amplified cancer immunotherapy.", BIOMATERIALS., vol. 242, 29 February 2020 (2020-02-29), XP086090537, DOI: 10.1016/j.biomaterials.2020.119928
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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