Title:
QUATERNARY AMMONIUM SALT COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/154287
Kind Code:
A1
Abstract:
Disclosed are a quaternary ammonium salt compound, a preparation method therefor and a use thereof. Provided is a novel structural compound as shown in formula Ⅰ, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof. The compound takes effect rapidly and has a long-time local anesthetic effect following a single dose, with the sensory nerve blocking time being greater than the motor nerve blocking time, has both a long-acting local anesthetic effect and a selective local anesthetic effect, significantly reduces side effects of the compositions QX314 and QX314 and a quaternary ammonium salt compound with surfactant structural characteristics, and is safer. That is, the compound of formula Ⅰ of the present invention and a pharmaceutically acceptable salt thereof can be used for preparing drugs that are safe and have a long-time local anesthetic effect and a selective local anesthetic effect, and have the advantages of a long local anesthesia time, good local anesthesia selectivity, less nerve injury and high safety.
Inventors:
LIU JIN (CN)
KE BOWEN (CN)
ZHANG WENSHENG (CN)
YANG JUN (CN)
TANG LEI (CN)
KE BOWEN (CN)
ZHANG WENSHENG (CN)
YANG JUN (CN)
TANG LEI (CN)
Application Number:
PCT/CN2019/074275
Publication Date:
August 15, 2019
Filing Date:
January 31, 2019
Export Citation:
Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
C07C237/06; A61K31/14; A61K31/16; A61K31/40; A61K31/44; A61P23/02; C07D205/04; C07D207/04; C07D211/00; C07D225/02; C07D227/04
Foreign References:
| CN1295558A | 2001-05-16 | |||
| CN103601650A | 2014-02-26 |
Other References:
COURTNEY KR, J PHARMACOL EXP THER, vol. 195, 1975, pages 225 - 236
CRAIG R. RIES., ANESTHESIOLOGY, vol. 111, 2009, pages 122 - 126
DANIEL S. KOHANE, PNAS, vol. 107, 2010, pages 3745 - 3750
"CAS", Database accession no. 15883-20-2
See also references of EP 3750870A4
CRAIG R. RIES., ANESTHESIOLOGY, vol. 111, 2009, pages 122 - 126
DANIEL S. KOHANE, PNAS, vol. 107, 2010, pages 3745 - 3750
"CAS", Database accession no. 15883-20-2
See also references of EP 3750870A4
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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