Title:
QUATERNARY AMMONIUM SALT COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/202568
Kind Code:
A1
Abstract:
Disclosed in the present invention are a quaternary ammonium salt compound, and a preparation method therefor and an application thereof. The general formula of the quaternary ammonium salt compound in the present invention is as follows: formula. According to the quaternary ammonium salt compound in the present invention, existing nitro labeling precursors are further improved, and aromatic amines are selectively quaternized, so that a labeling precursor having high stability and high labeling efficiency is prepared. By means of the labeling precursor, specific ligands targeting biological macromolecules in the body, especially targeting α7nAChR, can be prepared, and thus can be used as a radioactive or non-radioactive imaging agent for the diagnosis or treatment of Alzheimer's disease or other related diseases.
Inventors:
ZHANG HUABEI (CN)
YANG HAILONG (CN)
YANG HAILONG (CN)
Application Number:
PCT/CN2023/088939
Publication Date:
October 26, 2023
Filing Date:
April 18, 2023
Export Citation:
Assignee:
UNIV BEIJING NORMAL (CN)
International Classes:
C07C51/41; C07B59/00; C07C53/18; C07D295/135; C07D487/04; C07D487/08
Foreign References:
| CN114804990A | 2022-07-29 | |||
| CN107188900A | 2017-09-22 | |||
| CN103483277A | 2014-01-01 | |||
| US20050171079A1 | 2005-08-04 | |||
| US20050234031A1 | 2005-10-20 |
Attorney, Agent or Firm:
BEIJING ZHI CHENG HAN FANG IP AGENCY CO., LTD. (CN)
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