Title:
QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/147346
Kind Code:
A1
Abstract:
Compounds represented by general formula (I), their stereoisomers, tautomers, derivatives,
prodrugs or pharmaceutically accepted salts, and their preparation methods
or uses for the manufacture of a medicament of analgesics. In which R1 is
selected from H, substituted or unsubstituted phenyl, or substituted or unsubstituted heteroaryl;
A selected from bond, or substituted or unsubstituted hydrocarbon radical;R2,
R3 each other independently is selected from hydrogen or methyl, which
linked with the any position of spiro structure; n and m are integer of 0~2, and
do not represent 0 at same time; B, D each other independently is lineared or branched
alkylene; Y is selected from –CHR4-, O, S, -S(O)-, -SO2-,
-NR4 or substituted or unsubstituted phenylene, in which R4
selected from H, saturated or unsaturated C1-C6-alkyl, substituted or unsubstituted
aryl, or heteroaryl substituted methyl or ethyl; X- is pharmaceutically
accepted inorganic or organic anion. These compounds can be used as muscarine
receptor (M-receptor) and/or nicotine acetylcholine receptor (N-receptor)
agonist or antagonist. These compounds have good analgesic effect without side
effect such as addiction.
Inventors:
LI RUNTAO (CN)
SUN QI (CN)
YE JIA (CN)
YUE CAIQIN (CN)
WANG XIN (CN)
GE ZEMEI (CN)
LI CHANGLING (CN)
CHENG TIEMING (CN)
SUN QI (CN)
YE JIA (CN)
YUE CAIQIN (CN)
WANG XIN (CN)
GE ZEMEI (CN)
LI CHANGLING (CN)
CHENG TIEMING (CN)
Application Number:
PCT/CN2007/001887
Publication Date:
December 27, 2007
Filing Date:
June 15, 2007
Export Citation:
Assignee:
UNIV BEIJING (CN)
LI RUNTAO (CN)
SUN QI (CN)
YE JIA (CN)
YUE CAIQIN (CN)
WANG XIN (CN)
GE ZEMEI (CN)
LI CHANGLING (CN)
CHENG TIEMING (CN)
LI RUNTAO (CN)
SUN QI (CN)
YE JIA (CN)
YUE CAIQIN (CN)
WANG XIN (CN)
GE ZEMEI (CN)
LI CHANGLING (CN)
CHENG TIEMING (CN)
International Classes:
C07D487/10; A61K31/495; A61K31/499; A61P25/04; C07D295/06; C07D471/10; C07D498/10; C07D513/10; C07D519/00
Foreign References:
| CN1344717A | 2002-04-17 | |||
| CN1734385A | 2006-02-15 | |||
| CN1344717A | 2002-04-17 |
Other References:
GAO F.-L. ET AL.: "Unique spirocyclopiperazinium salt. I: synthesis and structure-Activity relationship of spirocyclopiperazinium salts as analgesics", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 9, 2003, pages 1535 - 1537, XP002420363
CHEMICAL ABSTRACTS, vol. 142, 2005, Columbus, Ohio, US; abstract no. (142:482060), XP008101272
CHEMICAL ABSTRACTS, vol. 131, 1999, Columbus, Ohio, US; abstract no. (131:228607), XP008101274
CHEMICAL ABSTRACTS, vol. 115, 1991, Columbus, Ohio, US; abstract no. 115:193160, XP008101659
WANG X. ET AL.: "Unique spirocyclopiperazinium salts. Part 2. Synthesis and structure-activity relationship of bisspirocyclopiperazinium salts as analgesics", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 10, 2003, pages 1729 - 1732, XP008100983
See also references of EP 2036909A4
CHEMICAL ABSTRACTS, vol. 142, 2005, Columbus, Ohio, US; abstract no. (142:482060), XP008101272
CHEMICAL ABSTRACTS, vol. 131, 1999, Columbus, Ohio, US; abstract no. (131:228607), XP008101274
CHEMICAL ABSTRACTS, vol. 115, 1991, Columbus, Ohio, US; abstract no. 115:193160, XP008101659
WANG X. ET AL.: "Unique spirocyclopiperazinium salts. Part 2. Synthesis and structure-activity relationship of bisspirocyclopiperazinium salts as analgesics", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 10, 2003, pages 1729 - 1732, XP008100983
See also references of EP 2036909A4
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (Kunxun Plaza Zhichun Road 9, HaidianDistrict, Beijing 3, CN)
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