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Title:
QUATERNARY ARYLCARBOXYLATE COMPOSITIONS FOR EXTRACTING C1 TO C4 CARBOXYLIC ACIDS FROM AQUEOUS STREAMS
Document Type and Number:
WIPO Patent Application WO/2017/105476
Kind Code:
A1
Abstract:
This invention relates to solvents for extracting Cito C^arboxylic acids from aqueous streams. More specifically, the extraction solvents include one or more salts composed of a phosphonium cation and an arylcarboxylate anion. The extraction solvents may further include one or more non-ionic liquid organic solvents as an enhancer. The extraction solvents are useful for extracting aqueous mixtures containing one or more lower carboxylic acids, such as monocarboxylic acids, alkoxycarboxylic acids, and halogen-containing carboxylic acids. Formula (I)

Inventors:
LIU, Jingyi (Apartment 202, 1st BuildingCentral District, Jintai Garden,Hanjiang Road,Shanto, Guangdong 0, 515000, CN)
WANG, Silu (17 Maiden Lane Centre, Reading RG6 3HD, 3HD, GB)
HARDACRE, Christopher (172 North Road, Belfast BT4 3DJ, Belfast BT4 3DJ, 3DJ, GB)
ROONEY, David, William (15 Thornhill Gardens, Lisburn BT28 3EQ, 3EQ, GB)
HEMBRE, Robert, Thomas (4201 Glaze Road, Johnson City, TN, 37601, US)
BARNICKI, Scott, Donald (1017 Oldham Court, Kingsport, TN, 37660, US)
SINK, Chester, Wayne (720 Chippendale Road, Kingsport, TN, 37660, US)
Application Number:
US2015/066575
Publication Date:
June 22, 2017
Filing Date:
December 18, 2015
Export Citation:
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Assignee:
EASTMAN CHEMICAL COMPANY (200 South Wilcox Drive, Kingsport, TN, 37660, US)
International Classes:
C07F9/54; B01D11/04; C07C63/04; C07C63/08; C07C63/70
Foreign References:
US20120138789A12012-06-07
US1839894A1932-01-05
US1860512A1932-05-31
US1861841A1932-06-07
US1917391A1933-07-11
US2028800A1936-01-28
US2050234A1936-08-04
US2063940A1936-12-15
US2076184A1937-04-06
US2123348A1938-07-12
US2157143A1939-05-09
US2184563A1939-12-26
US2199983A1940-05-07
US2204616A1940-06-18
US2269163A1942-01-06
US2275834A1942-03-10
US2275862A1942-03-10
US2275867A1942-03-10
US2317758A1943-04-27
US2333756A1943-11-09
US2359154A1944-09-26
US2384374A1945-09-04
US2395010A1946-02-19
US2537658A1951-01-09
US2567244A1951-09-11
US2854385A1958-09-30
US3052610A1962-09-04
US5662780A1997-09-02
US3816524A1974-06-11
US4909939A1990-03-20
JP2014040389A2014-03-06
JPH10114782A1998-05-06
US4965406A1990-10-23
Other References:
ANJA STOJANOVIC ET AL: "Phosphonium and Ammonium Ionic Liquids with Aromatic Anions: Synthesis, Properties, and Platinum Extraction", AUSTRALIAN JOURNAL OF CHEMISTRY: AN INTERNATIONAL JOURNAL FOR CHEMICAL SCIENCE, vol. 63, no. 3, 1 January 2010 (2010-01-01), AU, pages 511, XP055285399, ISSN: 0004-9425, DOI: 10.1071/CH09340
GUOKAI CUI ET AL: "Tuning Anion-Functionalized Ionic Liquids for Improved SO 2 Capture", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 52, no. 40, 12 August 2013 (2013-08-12), DE, pages 10620 - 10624, XP055260364, ISSN: 1433-7851, DOI: 10.1002/anie.201305234
GUOKAI CUI? ET AL: "Tuning the Basicity of Cyano-Containing Ionic Liquids to Improve SO 2 Capture through Cyano-Sulfur Interactions", CHEMISTRY - A EUROPEAN JOURNAL., vol. 21, no. 14, 16 February 2015 (2015-02-16), WEINHEIM, DE, pages 5632 - 5639, XP055285396, ISSN: 0947-6539, DOI: 10.1002/chem.201405683
SUSMITA DAS ET AL: "Ionic liquid-based fluorescein colorimetric pH nanosensors", RSC ADVANCES, vol. 3, no. 43, 1 January 2013 (2013-01-01), pages 21054, XP055285397, DOI: 10.1039/c3ra42394h
MURUGESAN S ET AL: "Benzoate-based room temperature ionic liquids-thermal properties and glycosaminoglycan dissolution", CARBOHYDRATE POLYMERS, APPLIED SCIENCE PUBLISHERS, LTD. BARKING, GB, vol. 63, no. 2, 3 February 2006 (2006-02-03), pages 268 - 271, XP027941268, ISSN: 0144-8617, [retrieved on 20060203]
J. MCFARLANE ET AL: "Room Temperature Ionic Liquids for Separating Organics from Produced Water", SEPARATION SCIENCE AND TECHNOLOGY, vol. 40, no. 6, 1 April 2005 (2005-04-01), NEW YORK, NY, US, pages 1245 - 1265, XP055287011, ISSN: 0149-6395, DOI: 10.1081/SS-200052807
FILIPE S OLIVEIRA ET AL: "Extraction of-lactic,-malic, and succinic acids using phosphonium-based ionic liquids", SEPARATION AND PURIFICATION TECHNOLOGY, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 85, 1 October 2011 (2011-10-01), pages 137 - 146, XP028440410, ISSN: 1383-5866, [retrieved on 20111008], DOI: 10.1016/J.SEPPUR.2011.10.002
EAGLESFIELD ET AL.: "Recovery of Acetic Acid from Dilute Aqueous Solutions by Liquid-Liquid Extraction - Part 1", THE INDUSTRIAL CHEMIST, vol. 29, 1953, pages 147 - 151
KING: "Amine-Based Systems for Carboxylic Acid Recovery: Tertiary Amines and the Proper Choice of Diluent Allow Extraction and Recovery from Water", CHEMTECH, vol. 5, 1992, pages 285 - 291
TAMADA ET AL.: "Extraction of Carboxylic Acids with Amine Extractants. 2. Chemical Interactions and Interpretation of Data", IND. ENG. CHEM. RES., vol. 29, 1990, pages 1327 - 1333
BLAUSER ET AL.: "Extraction of butyric acid with a solvent containing ammonium ionic liquid", SEP. PURIF. TECHNOL., vol. 119, 2013, pages 102 - 111, XP028758516, DOI: doi:10.1016/j.seppur.2013.09.005
MARTAK ET AL.: "Phosphonium ionic liquids as new, reactive extractants of lactic acid", CHEM. PAPERS, vol. 60, 2006, pages 395 - 398, XP008179295, DOI: doi:10.2478/s11696-006-0072-2
OLIVEIRA ET AL.: "Extraction of L-Lactic, L-Malic, and Succinic Acids Using Phosphonium-Based Ionic Liquids", SEP. PURIF TECH., vol. 85, 2012, pages 137 - 146, XP028440410, DOI: doi:10.1016/j.seppur.2011.10.002
POOLE ET AL.: "Extraction of Organic Compounds with Room Temperature Ionic Liquids", J. CHROMATOGR. (A, vol. 1217, 2010, pages 2268 - 2286, XP026983886
ROBERTSON ET AL.: "Industrial Preparation of Phosphonium Ionic Liquids", GREEN CHEM., vol. 5, 2003, pages 143 - 152
NEVES ET AL.: "Separation of Ethanol-Water Mixtures by Liquid-Liquid Extraction Using Phosphonium-Based Ionic Liquids", GREEN CHEM., vol. 13, 2011, pages 1517 - 1526
"Room Temperature Ionic Liquids for Separating Organics from Produced Waters", SEP. SCI. & TECH., vol. 40, 2005, pages 1245 - 1265
"Extraction of Organic Acids Using Imidazolium-Based Ionic Liquids and Their Toxicity to Lactobacillus rhamnosus", SEP. AND PURIF. TECH., vol. 40, 2004, pages 97 - 101
JUDSON KING: "Handbook of Solvent Extraction", 1991, KRIEGER PUBL. CO., article "Acetic Acid Extraction"
KOGELNIG ET AL.: "Greener Synthesis of New Ammonium Ionic Liquids and their Potential as Extracting Agents", TETRAHEDRON LETTERS, vol. 49, 2008, pages 2782 - 2785, XP022558383, DOI: doi:10.1016/j.tetlet.2008.02.138
FERGUSON ET AL.: "A Greener, Halide-Free Approach to Ionic Liquid Synthesis", PURE & APPL. CHEM., vol. 84, 2012, pages 723 - 744
"Handbook of Solvent Extraction", 1991, KRIEGER PUBLISHING COMPANY, pages: 275 - 501
WARDELL; KING: "Solvent Equilibria for Extraction of Carboxylic Acids from Water", J. CHEM. AND ENG. DATA, vol. 23, no. 2, 1978, pages 144 - 148
Attorney, Agent or Firm:
PHAN, Nhat, D. (Phan Law Group PLLC, P.O. Box 748Alexandria, VA, 22313-0748, US)
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Claims:
CLAIMS

We claim:

1 . A solvent for extracting a Ci to C4 carboxylic acid from water, the solvent comprising:

(a) a quaternary phosphonium arylcarboxylate salt; and

(b) a non-ionic organic solvent,

wherein the non-ionic organic solvent is not the extract, and

wherein the arylcarboxylate salt has the general formula 1 :

1 wherein

R1 , R2, R3 and R4 are each independently a Ci to C26 hydrocarbyl group, provided that R1 , R2, R3, and R4 collectively have a total of at least 24 carbon atoms; and

Ar is an aryl group having 6 to 24 carbon atoms.

2. The extraction solvent according to claim 1 , wherein Ar is substituted with a halogen, alkyl group, aryl group, halogen-substituted alkyl group, halogen-substituted aryl group, secondary alkyl or aryl amino group, tertiary alkyl or aryl amino group, halogen-substituted secondary alkyl or aryl amino group, halogen-substituted tertiary alkyl or aryl amino group, nitro group, alkyl or aryl ether group, halogen-substituted alkyl or aryl ether group, or combinations thereof.

3. The extraction solvent according to claim 1 , wherein the arylcarboxylate salt comprises a tetraalkylphosphonium salt of a benzoate anion selected from the group consisting of benzoate, 2-methyl benzoate, 3-methyl benzoate, 4- methylbenzoate, 4-methylamino benzoate, 4-trifluoromethoxy benzoate, 2- nitrobenzoate, pentafluorobenzoate, and 3-dimethylamino benzoate.

4. The extraction solvent according to claim 1 , wherein the arylcarboxylate salt comprises a trihexyl(tetradecyl)phosphonium salt of a benzoate anion selected from the group consisting of benzoate, 2-methyl benzoate, 3-methyl benzoate, 4- methylbenzoate, 4-methylamino benzoate, 4-trifluoromethoxy benzoate, 2- nitrobenzoate, pentafluorobenzoate, and 3-dimethylamino benzoate.

5. The extraction solvent according to claim 1 , wherein the arylcarboxylate salt comprises trihexyl(tetradecyl)phosphonium arylcarboxylate or

trioctyl(methyl)phosphonium arylcarboxylate.

6. The extraction solvent according to claim 1 , which comprises at least two of the arylcarboxylate salts.

7. The extraction solvent according to claim 1 , wherein the non-ionic organic solvent is selected from the group consisting of higher carboxylic acids, ethers, esters, ketones, aromatic hydrocarbons, chlorinated hydrocarbons, and nitriles.

8. The extraction solvent according to claim 7, wherein the higher carboxylic acid is selected from the group consisting of n-butyric acid, isobutyric acid, n-valeric acid, isovaleric acid, n-hexanoic acid, 2-ethylbutyric acid, heptanoic acid, n-octanoic, 2- ethylhexanoic acids, nonanoic acids, decanoic acids, dodecanoic acids, stearic acid, oleic acid, linolenic acid, and mixed vegetable-derived acids.

9. The extraction solvent according to claim 7, wherein the higher carboxylic acid is selected from the group consisting of benzoic acid, 4-methylaminobenzoic acid, trifluoromethoxybenzoic acid, and 3-dimethylaminobenzoic acid.

10. The extraction solvent according to claim 7, wherein the non-ionic organic solvent is selected from the group consisting of ethyl acetate, n-propyl acetate, n-propyl formate, i-propyl acetate, i-propyl formate, n-butyl acetate, n-butyl formate, i-butyl acetate, i-butyl formate, n-propyl propionate, i-propyl propionate, 2-pentanone, 3- pentanone, methyl isobutyl ketone, 3-methyl-2-butanone, 2-hexanone, 2-heptanone, cyclohexanone, 4-methyl-2-pentanone, 2,4-dimethyl-3-pentanone, 5-methyl-2- hexanone, 4-heptanone, 2-octanone, 5-nonanone, 2,8-dimethyl-4-heptanone, 3,3,5- trimethyl cyclohexanone, isophorone, diethyl ether, methyl propyl ether, dipropyl ether, di-isopropyl ether, methyl t-butyl ether, tertiary amyl methyl ether, ethyl butyl ether, toluene, m-xylene, p-xylene, and o-xylene.

1 1 . The extraction solvent according to claim 10, wherein the non-ionic organic solvent is selected from the group consisting of methyl isobutyl ketone, toluene, isopropyl acetate, and methyl t-butyl ether.

12. The extraction solvent according to claim 1 , which comprises at least two of the non-ionic organic solvents.

13. The extraction solvent according to claim 1 , which comprises 10 to 90 weight percent of the arylcarboxylate salt and 10 to 90 weight percent of the non-ionic organic solvent.

14. The extraction solvent according to claim 1 , which comprises 50 to 90 weight percent of the arylcarboxylate salt and 10 to 50 weight percent of the non-ionic organic solvent.

15. A process for separating a Ci to C4 carboxylic acid from water, the process comprising:

contacting a feed mixture comprising a Ci to C4 carboxylic acid and water with an extraction solvent comprising a quaternary phosphonium arylcarboxylate salt and a non- ionic organic solvent at conditions effective to form (a) an extract mixture comprising the arylcarboxylate salt, the non-ionic organic solvent, and at least a portion of the Ci to C4 carboxylic acid from the feed mixture and (b) a raffinate mixture comprising water and less of the Ci to C4 carboxylic acid compared to the feed mixture,

wherein the non-ionic organic solvent is not the extract, and

wherein the arylcarboxylate salt has the general formula 1 :

1 wherein

R1 , R2, R3 and R4 are each independently a Ci to C26 hydrocarbyl group, provided that R1 , R2, R3, and R4 collectively have a total of at least 24 carbon atoms; and

Ar is an aryl group having 6 to 24 carbon atoms.

16. The process according to claim 15, wherein the arylcarboxylate salt comprises a tetraalkylphosphonium salt of a benzoate anion selected from the group consisting of benzoate, 2-methyl benzoate, 3-methyl benzoate, 4-methylbenzoate, 4- methylamino benzoate, 4-trifluoromethoxy benzoate, 2-nitrobenzoate,

pentafluorobenzoate, and 3-dimethylamino benzoate.

17. The process according to claim 15, wherein the arylcarboxylate salt comprises trihexyl(tetradecyl)phosphonium arylcarboxylate or

trioctyl(methyl)phosphonium arylcarboxylate.

18. The process according to claim 15, wherein the extraction solvent comprises at least two of the arylcarboxylate salts.

19. The process according to claim 15, wherein the non-ionic organic solvent is selected from the group consisting of higher carboxylic acids, ethers, esters, ketones, aromatic hydrocarbons, chlorinated hydrocarbons, and nitriles.

20. The process according to claim 19, wherein the higher carboxylic acid is selected from the group consisting of n-butyric acid, isobutyric acid, n-valeric acid, isovaleric acid, n-hexanoic acid, 2-ethylbutyric acid, heptanoic acid, n-octanoic, 2- ethylhexanoic acids, nonanoic acids, decanoic acids, dodecanoic acids, stearic acid, oleic acid, linolenic acid, and mixed vegetable-derived acids.

21 . The process according to claim 19, wherein the higher carboxylic acid is selected from the group consisting of benzoic acid, 4-methylaminobenzoic acid, trifluoromethoxybenzoic acid, and 3-dimethylaminobenzoic acid.

22. The process according to claim 19, wherein the non-ionic organic solvent is selected from the group consisting of ethyl acetate, n-propyl acetate, n-propyl formate, i-propyl acetate, i-propyl formate, n-butyl acetate, n-butyl formate, i-butyl acetate, i-butyl formate, n-propyl propionate, i-propyl propionate, 2-pentanone, 3- pentanone, methyl isobutyl ketone, 3-methyl-2-butanone, 2-hexanone, 2-heptanone, cyclohexanone, 4-methyl-2-pentanone, 2,4-dimethyl-3-pentanone, 5-methyl-2- hexanone, 4-heptanone, 2-octanone, 5-nonanone, 2,8-dimethyl-4-heptanone, 3,3,5- trimethyl cyclohexanone, isophorone, diethyl ether, methyl propyl ether, dipropyl ether, di-isopropyl ether, methyl t-butyl ether, tertiary amyl methyl ether, ethyl butyl ether, toluene, m-xylene, p-xylene, and o-xylene.

23. The process according to claim 15, wherein the extraction solvent comprises at least two of the non-ionic organic solvents.

24. The process according to claim 15, wherein the extraction solvent comprises 10 to 90 weight percent of the arylcarboxylate salt and 10 to 90 weight percent of the non-ionic organic solvent.

25. The process according to claim 15, wherein the Ci to C4 carboxylic acid comprises acetic acid.

26. The process according to claim 15, wherein the feed mixture comprises at least two of the Ci to C4 carboxylic acids.

27. The process according to claim 15, wherein the feed mixture comprises 0.5 to 60 weight percent of the Ci to C4 carboxylic acid.

28. The process according to claim 15, wherein the feed mixture is derived from the production of cellulose esters.

29. The process according to claim 15, wherein the weight ratio of the extraction solvent to the feed mixture ranges from 0.2 to 10: 1 .

30. The process according to claim 15, which further comprises:

separating the extract mixture from the raffinate mixture; and

recovering the Ci to C4 carboxylic acid from the extract mixture by distillation at atmospheric pressure or lower.

Description:
QUATERNARY ARYLCARBOXYLATE COMPOSITIONS FOR EXTRACTING d TO C 4 CARBOXYLIC ACIDS FROM AQUEOUS STREAMS

FIELD OF THE INVENTION

[0001] The invention generally relates to solvents for extracting Ci to C carboxylic acids from aqueous streams, compositions containing the same, and processes for separating the acids from water.

BACKGROUND OF THE INVENTION

[0002] The recovery of Ci to C carboxylic acids (hereinafter "lower acids") from aqueous streams is a common industrial problem arising from a variety of reaction and processing steps. Simple distillation of wet acid streams to recover glacial acids is hampered by unfavorable vapor-liquid equilibrium (VLE) and high energy costs with all Ci to C carboxylic acids. Examples of unfavorable VLE include the formic acid-water maximum-boiling homogeneous azeotrope, the acetic acid-water VLE "pinch" (a region of low relative volatility), and the minimum-boiling homogeneous azeotropes with water and all C3-C carboxylic acids.

[0003] Various approaches have been suggested in the art to address the problem of lower acid recovery from wet acid feeds. For example, one approach subjects an aqueous lower acid solution to azeotropic distillation together with an entraining component capable of forming a heterogeneous minimum-boiling azeotrope with water, so that the azeotrope boils at a temperature substantially lower than pure water, the pure lower acid, and any acid-water azeotrope. An extraction step often precedes the azeotropic distillation. The extraction step partitions the carboxylic acid into a water- immiscible solvent (which is often the same as the azeotropic entrainer) in order to remove the bulk of the water from the recovered acid. Many examples of azeotropic distillation, extraction, and combinations thereof using conventional organic solvents have been proposed in the art. These include U.S. Patent Nos. 1 ,839,894; 1 ,860,512; 1 ,861 ,841 ; 1 ,917,391 ; 2,028,800; 2,050,234; 2,063,940; 2,076, 184; 2, 123,348;

2, 157, 143; 2, 184,563; 2, 199,983; 2,204,616; 2,269, 163; 2,275,834; 2,275,862; 2,275,867; 2,317,758; 2,333,756; 2,359, 154; 2,384,374; 2,395,010; 2,537,658;

2,567,244; 2,854,385; 3,052,610; and 5,662,780, and Eaglesfield et al., "Recovery of Acetic Acid from Dilute Aqueous Solutions by Liquid-Liquid Extraction - Part 1 ," The Industrial Chemist, Vol. 29, pp. 147-151 (1953).

[0004] Several solvent characteristics determine the capital and energy costs of extraction-distillation processes for the extractive recovery of lower acids from wet acid feeds. The solvent for the extraction process is immiscible with water and meets two criteria:

a) The solvent shows some selectivity between extraction of the carboxylic acid and water, i.e., the ratio of carboxylic acid to water in the extraction solvent after extraction is substantially larger than in the wet acid feed stream. This factor can be quantified as the weight ratio of water to acid in the extract stream as defined in more detail below.

b) The solvent shows sufficient affinity and capacity for the lower carboxylic acid. These characteristics are quantifiable from experimentally determined equilibrium partition coefficients as defined in more detail below.

[0005] The equilibrium partition coefficient (also used interchangeably with the term "partition coefficient") for component A (the lower carboxylic acid) is defined as follows: weight percent A in solvent phase

P(A) =

weight percent A in aqueous phase

[0006] The partition coefficient is a measure of the relative concentrations of the solute to be extracted in the two phases. The value of the acid partition coefficient is directly related to the amount of solvent that is required to effect a given extraction. Low values of the partition coefficient indicate high levels of solvent are required, and high values of the partition coefficient indicate low levels of solvent are required. Since the acid partition coefficient changes with acid concentration, the minimum amount of solvent required to effect a given amount of acid extraction also changes. Thus, the controlling solvent flow requirement for the extraction is dictated by the lowest value of the acid partition coefficient as the acid concentration varies from the high of the inlet wet acid feed to the low of the outlet acid concentration of the exiting raffinate stream.

[0007] The controlling acid partition coefficient may be defined as:

Pcont = minimum(Praff, Pextr) where

Praff = acid partition coefficient at an acid concentration approaching that desired in the raffinate stream (i.e., at low acid concentration); and

Pextr = acid partition coefficient at an acid concentration approaching that desired in the extract stream (i.e., at high acid concentration).

[0008] The most important water-acid selectivity value is that at the extract end of the extraction cascade. It is defined as:

Rextr = Wextr / A ex tr where

Wextr = weight fraction of water in the extract product stream; and

Aextr = weight fraction of acid in the extract product stream.

[0009] The controlling partition coefficient, P CO nt, and extract water-to-acid ratio, R ex tr, may be combined to yield an overall extraction factor, ε, which is a simple measure of the efficacy of a given solvent for recovering lower acids from wet acid feeds in an extraction-distillation process. The extraction factor, ε, is defined as: ε = Pcont /Rextr = (Pcont * A ex tr) / W ex tr

[0010] Generally, the higher the extraction factor, the lower the capital and energy costs are for a given extraction.

[0011] Extraction solvents that exhibit the inverse behavior are also known. That is, their acid partition coefficient is lowest at the extract end of the cascade (high acid concentration) and highest at the raffinate end (low acid concentration). Examples of such solvents include nitriles, phosphate esters, phosphine oxides (U.S. Patent Nos. 3,816,524 and 4,909,939), and amines (e.g., King, "Amine-Based Systems for

Carboxylic Acid Recovery: Tertiary Amines and the Proper Choice of Diluent Allow Extraction and Recovery from Water," CHEMTECH, Vol. 5, pp. 285-291 (1992); and Tamada et al., "Extraction of Carboxylic Acids with Amine Extractants. 2. Chemical Interactions and Interpretation of Data," Ind. Eng. Chem. Res., Vol. 29, pp. 1327-1333 (1990)).

[0012] This inverse behavior (partition coefficient highest at low acid concentration) has also been observed for a phosphonium- and an ammonium-phosphinate ionic liquid (Blauser et al., "Extraction of butyric acid with a solvent containing ammonium ionic liquid," Sep. Purif. Technol., Vol. 1 19, pp. 102-1 1 1 (2013); Martak et al., "Phosphonium ionic liquids as new, reactive extractants of lactic acid," Chem. Papers, Vol. 60, pp. 395- 98 (2006)) and a phosphonium carboxylate salt (Oliveira et al., "Extraction of L-Lactic, L-Malic, and Succinic Acids Using Phosphonium-Based Ionic Liquids," Sep. Purif.

Tech., Vol. 85, pp. 137-146 (2012)).

[0013] The use of hydrophobic ionic liquids as extraction solvents has been reviewed by Poole et al., "Extraction of Organic Compounds with Room Temperature Ionic Liquids," J. Chromatogr. (A), Vol. 1217, pp. 2268-2286 (2010). The development and advantages of phosphonium ionic liquids have been reviewed by Robertson et al., "Industrial Preparation of Phosphonium Ionic Liquids", Green Chem., Vol. 5, pp. 143- 152 (2003)), and their application to the extraction of ethanol from fermentation broths is addressed by Neves et al., "Separation of Ethanol-Water Mixtures by Liquid-Liquid Extraction Using Phosphonium-Based Ionic Liquids," Green Chem., Vol. 13, pp. 1517- 1526 (201 1 ).

[0014] Extraction of lower carboxylic acids using imidazolium and phosphonium ionic liquids has also been reported. For acetic acid, McFarlane et al. report on bmim-NTf 2 , omim-NTf2, bmim-PF6, P 6 66,u-LABS/nonanol, P 444 u-LABS/nonanol, and Ρβββ,η- OSO 2 Me ("Room Temperature Ionic Liquids for Separating Organics from Produced Waters," Sep. Sci. & Tech., Vol 40., 1245-1265 (2005)). Hashikawa claims P 22 2,8-NTf 2 for acetic, propionic, and butyric acids ("Method for Producing Acetic Acid," JP 2014/40389, Daicel, (Mar 6, 2014)). And Matsumoto et al. report on bmim-PF 6 , hmim- PF 6 , and omim-PF 6 ("Extraction of Organic Acids Using Imidazolium-Based Ionic

Liquids and Their Toxicity to Lactobacillus rhamnosus," Sep. and Purif. Tech., Vol. 40, pp. 97-101 (2004)).

[0015] None of these documents, however, employed a quaternary phosphonium arylcarboxylate. Moreover, lower carboxylic acid partitioning was poor in the reports by McFarlane, Hashikawa, and Matsumoto. Furthermore, adding an alcohol to

phosphonium ionic liquid compositions for extracting lower carboxylic acids is

recognized by those skilled in the art as not being preferred, due to the formation of carboxylic ester derivatives of the alcohols with the acid extracts, especially in

downstream distillation or evaporative processes for purifying the lower carboxylic acids. This exclusion is addressed by Judson King, "Acetic Acid Extraction," Handbook of Solvent Extraction, Krieger Publ. Co. (1991 ).

[0016] Hashikawa, in particular, claims only using ionic liquids with fluorine-containing anions, such as bis(fluorosulfonyl)imide, bis(fluoroalkylsulfonyl)imides,

tris(perfluoroalkyl)trifluorophosphates, hexafluorophosphates, tetrafluoroborates, and perfluoroalkylsulfonates. These anions add significant cost and toxicity concerns to large-scale applications. In addition, Hashikawa claims ionic liquids with phosphonium salts containing a total of only ten carbon atoms or higher. According to the data presented in the Hashikawa application, triethyl(octyl)phosphonium

bis(trifluoromethylsulfonyl)-imide exhibits relatively poor extraction behavior for acetic acid, with a small two-phase region, low capacity for acetic acid, and very low partition coefficients (between about 0.06 and 0.1 ).

[0017] Despite the poor performance of the above reported and claimed ionic liquid systems, the extremely low vapor pressure of ionic liquids remains an attractive physical property for a lower-carboxylic-acid-extracting phase. Thus, there is a need in the art for an extraction solvent with excellent partitioning of lower carboxylic acids from aqueous solutions and that enables the simple separation of these acids via distillation from the solvent. There is also a need for extraction solvents with high extraction factors whereby Ci to C 4 carboxylic acids can be recovered from wet acid feeds in an energy-efficient and cost-effective manner.

[0018] The present invention addresses these needs as well as others, which will become apparent from the following description and the appended claims.

SUMMARY OF THE INVENTION

[0019] The invention is as set forth in the following detailed description and the appended claims.

[0020] Briefly, in one aspect, the present invention provides a solvent for extracting a Ci to C 4 carboxylic acid from water. The extraction solvent comprises (a) a quaternary phosphonium arylcarboxylate salt and (b) a non-ionic organic solvent with the proviso that the non-ionic organic solvent is not the extract. The arylcarboxylate salt has the general formula 1 :

1 wherein

R 1 , R 2 , R 3 and R 4 are each independently a Ci to C26 hydrocarbyl group, provided that R 1 , R 2 , R 3 , and R 4 collectively have a total of at least 24 carbon atoms; and

Ar is an aryl group having 6 to 24 carbon atoms.

[0021] In another aspect, the present invention provides a composition for separating a Ci to C 4 carboxylic acid from water. The composition comprises:

(a) a quaternary phosphonium arylcarboxylate salt according to the invention;

(b) a non-ionic organic solvent according to the invention;

(c) a Ci to C 4 carboxylic acid; and

(d) water. [0022] In yet another aspect, the present invention provides a process for separating a Ci to C 4 carboxylic acid from water. The process comprises contacting a feed mixture comprising a Ci to C 4 carboxylic acid and water with an extraction solvent according to the invention at conditions effective to form (a) an extract mixture comprising the arylcarboxylate salt, the non-ionic organic solvent, and at least a portion of the Ci to C 4 carboxylic acid from the feed mixture and (b) a raffinate mixture comprising water and less of the Ci to C 4 carboxylic acid compared to the feed mixture.

[0023] In one embodiment, the present invention is directed to a process for separating acetic acid from water. The process comprises contacting a feed mixture comprising acetic acid and water with an extraction solvent comprising a quaternary phosphonium arylcarboxylate salt according to the invention at conditions effective to form (a) an extract mixture comprising the arylcarboxylate salt and at least a portion of the acetic acid from the feed mixture and (b) a raffinate mixture comprising water and less of the acetic acid compared to the feed mixture.

BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 is an H 1 NMR spectrum of P 6 66 , u-Bz in CDCI 3 from Example 2.

[0025] Figure 2 is an H 1 NMR spectrum of P 6 66 , u-4-MABz in CDCI 3 from Example 2.

[0026] Figure 3 is an H 1 NMR spectrum of P 6 66 , u-4-CF 3 OBz in CDCI 3 from Example 2.

[0027] Figure 4 is an H 1 NMR spectrum of P 6 66 , u-2-NO 2 Bz in CDCI 3 from Example 2.

[0028] Figure 5 is an H 1 NMR spectrum of Peee.u-FsBz in CDCI 3 from Example 2.

[0029] Figure 6 is an H 1 NMR spectrum of P 6 66 , u-3-DMABz in CDCI 3 from Example 2.

DETAILED DESCRIPTION OF THE INVENTION

[0030] It has been found, surprisingly, that when certain quaternary phosphonium arylcarboxylates are combined with aqueous solutions of a lower carboxylic acid, the resulting partitioning of the lower acid into the phosphonium arylcarboxylate phase can be fairly high, particularly when the concentration of the lower acid is low (e.g., < 5 wt%). The arylcarboxylates show superior selectivity for lower acid extraction over co- extraction of water. As a result, the extraction factor, ε, is significantly higher for the arylcarboxylates than other classes of lower acid extraction solvents, and are thus particularly useful for recovering lower acids from wet acid streams.

[0031] Accordingly, in one aspect, the present invention provides quaternary phosphonium arylcarboxylates that are useful for separating lower acids from aqueous streams. The arylcarboxylates are depicted by the general formula 1 :

1 wherein

R 1 , R 2 , R 3 and R 4 are each independently a Ci to C 26 hydrocarbyl group, provided that R 1 , R 2 , R 3 , and R 4 collectively have a total of at least 24 carbon atoms; and

Ar is an aryl group having 6 to 24 carbon atoms.

[0032] As used herein, the term "hydrocarbyl" refers to a group containing hydrogen and carbon atoms, and may be straight-chained or branched, cyclic or acylic, and saturated or unsaturated.

[0033] Each of R 1 , R 2 , R 3 , and R 4 may have the same number of carbon atoms or may be of different lengths. In one embodiment, R 1 , R 2 , R 3 , and R 4 collectively have not more than 54 carbon atoms. In another embodiment, each of R 1 , R 2 , R 3 , and R 4 has at least 6 carbon atoms. In other embodiments, each of R 1 , R 2 , R 3 , and R 4 contains from 6 to 24 carbon atoms, 6 to 20 carbon atoms, 6 to 18 carbon atoms, 6 to 14 carbon atoms, or 8 to 14 carbon atoms.

[0034] Ar represents any aromatic hydrocarbon group for which the associated arylcarboxylate anion (ArC0 2 _ ) when combined with a phosphonium group [PR 1 R 2 R 3 R 4 ], defined as above, renders the salt hydrophobic. Generally, the aryl group represented by Ar may have 6 to 24 carbon atoms. In one embodiment, the aryl group has from 6 to 20 carbon atoms. In another embodiment, the aryl group has 6 to 16 carbon atoms. In yet another embodiment, the aryl group has 6 to 12 carbon atoms.

[0035] The aryl group represented by Ar may be mono- or polycyclic. It may be substituted with a halogen, alkyi group, aryl group, halogen-substituted alkyi group, halogen-substituted aryl group, secondary alkyi or aryl amino group, tertiary alkyi or aryl amino group, halogen-substituted secondary alkyi or aryl amino group, halogen- substituted tertiary alkyi or aryl amino group, nitro group, alkyi or aryl ether group, halogen-substituted alkyi or aryl ether group, or combinations thereof.

[0036] In one embodiment, the arylcarboxylate anion (ArC0 2 _ ) is benzoate.

[0037] In another embodiment, the arylcarboxylate anion (ArCO^) is a substituted benzoate.

[0038] By "hydrophobic," it is meant that the salt is immiscible in water at typical extraction conditions, e.g., has less than 5 wt% miscibility in water at 20°C.

[0039] The arylcarboxylate salt is the liquid state under typical extraction conditions.

[0040] In one particular embodiment, the arylcarboxylate anion (ArCO^) has the structural formula 2:

wherein R 5 to R 9 are each independently selected from the group consisting of H, F, CI, Br, alkyi, aryl, halogen-substituted alkyi, halogen-substituted aryl, alkoxy, aryloxy, halogen-substituted alkoxy, halogen-substituted aryloxy, secondary alkyi and aryl amino, tertiary alkyl and aryl amino, halogen-substituted secondary alkyl and aryl amino, halogen-substituted tertiary alkyl and aryl amino, and nitro.

[0041] Adjacent groups R 5 to R 9 may be linked in a cyclic hydrocarbon structure, which may be saturated or unsaturated. For example, adjacent groups R 6 and R 7 or R 5 and R 6 may be connected to form an unsaturated cyclic structure as illustrated in formulas 3 and 4, respectively, below:

wherein R 10 to R 13 are each independently defined the same as R 5 to R 9 above.

[0042] In one Japanese patent publication, quaternary phosphonium benzoates were claimed for curing epoxy resins (JP 10-1 14,782 (1986)). U.S. Patent No. 4,965,406 reported the formation of tetrahexylquaternary phosphonium benzoates in the metal- catalyzed aerobic oxidation of toluene derivatives. There is no example of quaternary phosphonium arylcarboxylates being applied to the extraction of an organic compound, let alone a lower carboxylic acid; and there are no known examples of functionalized benzoate quaternary salts, such as nitro- or dimethylamino-benzoate.

[0043] The arylcarboxylate derivatives described herein that do not have CAS registration numbers are previously unknown and, thus, are specifically contemplated as being within the scope of the present invention.

[0044] The phosphonium arylcarboxylates having the structure of formula 1 may be produced by known methods from readily available precursors. See, e.g., Kogelnig et al., "Greener Synthesis of New Ammonium Ionic Liquids and their Potential as Extracting Agents," Tetrahedron Letters, Vol. 49, pp. 2782-2785 (2008) and Ferguson et al., "A Greener, Halide-Free Approach to Ionic Liquid Synthesis," Pure & Appl. Chem., Vol. 84, pp. 723-744 (2012)). The former approach involves the metathesis of an alkali arylcarboxylate with a quaternary ammonium halide, while the latter approach employs an ion-exchange resin. An example of a readily available precursor is trihexyl(tetra- decyl)phosphonium chloride.

[0045] So while synthetic methods of a general nature are known for making quaternary phosphonium arylcarboxylates, quaternary benzoates are only sparsely known in the patent literature. As noted above, there are no examples using quaternary phosphonium arylcarboxylates for extracting organic compounds and thus not for any lower carboxylic acids.

[0046] Mixtures containing more than one quaternary cation and more than one arylcarboxylate anion are also useful for the extraction of lower acids from aqueous solutions and, therefore, are also contemplated as being within the scope of the present invention.

[0047] In one embodiment, the arylcarboxylate salt comprises a tetraalkylphosphon- ium salt of a benzoate anion selected from the group consisting of benzoate, 2-methyl benzoate, 3-methyl benzoate, 4-methylbenzoate, 4-methylamino benzoate, 4-trifluoro- methoxy benzoate, 2-nitrobenzoate, pentafluorobenzoate, and 3-dimethylamino benzoate.

[0048] In another embodiment, the arylcarboxylate salt comprises a

trihexyl(tetradecyl)phosphonium salt of a benzoate anion selected from the group consisting of benzoate, 2-methyl benzoate, 3-methyl benzoate, 4-methylbenzoate, 4- methylamino benzoate, 4-trifluoromethoxy benzoate, 2-nitrobenzoate,

pentafluorobenzoate, and 3-dimethylamino benzoate.

[0049] In a further embodiment, the arylcarboxylate salt comprises

trihexyl(tetradecyl)phosphonium arylcarboxylate or trioctyl(methyl)phosphonium arylcarboxylate. The arylcarboxylate anion may be selected from the group consisting of benzoate, 3-dimethylaminobenzoate, 4-methylaminobenzoate, 4- trifluoromethoxybenzoate, 2-nitrobenzoate, and pentafluorobenzoate. [0050] In a second aspect, the invention provides a composition A:

A

[0051] Composition A represents a unique biphasic mixture comprising a quaternary phosphonium arylcarboxylate according to the general formula 1 , a lower acid, and water. Other species may also be present. Composition A is useful for separating the lower acid from water.

[0052] As noted above, lower acids refer to Ci to C 4 carboxylic acids. By way of example, the carboxylic acids may be monocarboxylic acids, alkoxycarboxyhc acids, or halogen-containing carboxylic acids. Examples of such acids include formic acid, acetic acid, propionic acid, acrylic acid, n-butyric acid, isobutyric acid, methacrylic acid, chloroacetic acid, dichloroacetic acid, trichloroacetic acid, trifluoroacetic acid, methoxyacetic acid, and the like. In one embodiment, the lower acid comprises acetic acid.

[0053] Examples of processes that produce diluted aqueous carboxylic acid- containing streams (i.e., comprising less than 1 weight percent to 60 weight percent of Ci to C 4 carboxylic acids in an aqueous mixture, which may be referred to as "wet acid feeds") include the production of cellulose esters or terephthalic acid, the production of ketene or higher ketenes from high temperature dehydration of carboxylic acids and anhydrides, the hydrolysis of poly(vinylacetate), the production of Fischer-Tropsch liquids, oil and gas production (yielding "produced waters"), the ketonization of carboxylic acids to ketones, the oxidation of ethylene to acetaldehyde by the Wacker process, the oxidation of propylene to acrylic acid, the oxidation of oxo aldehydes to their carboxylic acids, hydrocarboxylation of formaldehyde with water and carbon monoxide, the oxidation of isobutylene to methacrylic acid, pyroligneous acids, fermentations broths, vinegar streams, and the like. Vinegar streams refer to aqueous streams containing acetic acid. In one embodiment, the wet acid feed is derived from the production of cellulose esters.

[0054] The wet acid feed may comprise from 0.5 to 60 weight percent of one or more of the Ci to C 4 carboxylic acids. More preferably, the wet acid feed comprises from 0.5 to 45 weight percent of the Ci to C 4 carboxylic acids. Most preferably, the wet acid feed comprises from 0.5 to 35 weight percent of the Ci to C 4 carboxylic acids. Because of the unusually high acid partition coefficients of the arylcarboxylate salts of the invention even at low acid concentrations, the extraction solvent of the instant invention may be used advantageously to extract lower acids at concentrations as low as 0.5 weight percent in the wet acid feed.

[0055] As used herein, the terms "feed" and "feed mixture" are intended to have their commonly understood meaning in the liquid-liquid extraction art, which is the solution that contains the materials to be extracted or separated. In the present invention, one example of a "feed" is a mixture composed of one or more of formic, acetic, propionic, acrylic, n-butyric, isobutyric, methacrylic, methoxyacetic, chloroacetic, dichloroacetic, trichloroacetic, and trifluoroacetic acids in water. In the present invention, the terms "feed" and "feed mixture" are synonymous with "aqueous acid stream," "weak acid stream," and "wet acid feed."

[0056] The term "extraction solvent," as used herein, is intended to be synonymous with the term "extractant" and is intended to mean the water-immiscible or hydrophobic liquid that is used in the extraction process to extract materials or solutes from the feed.

[0057] The weight ratio of arylcarboxylate to wet acid feed in composition A may vary over a wide range. For example, the ratio may range from 0.2 to 10: 1 or, more preferably, from 0.3 to 4: 1 .

[0058] A feature of composition A is that it separates into two phases, an aqueous and an organic phase, with the lower acid distributed between them. The biphasic nature of composition A is desirable in order to physically separate the lower acid from the aqueous solution. The amount of lower acid distributed between the phases is only limited by the biphasic property of the system. Preferably, the lower acid amount does not exceed a level at which the biphasic nature of the composition is lost. Likewise, other materials may also be present, but only to the extent that the biphasic nature of the system is retained. Complex systems that form more than two phases are not preferred, since such a system can obscure the effective separation of the lower acid.

[0059] Quaternary phosphonium arylcarboxylates that form greater than two-phase systems, emulsions, or other complex mixtures may be simplified by adding a hydrophobic, non-ionic organic co-solvent to the quaternary phosphonium

arylcarboxylate extracting phase.

[0060] Thus, in a third aspect, the present invention provides a solvent for extracting lower carboxylic acids (Ci - C 4 ) from water. The extraction solvent comprises the phosphornium arylcarboxylate defined by the general formula 1 above and a non-ionic organic (NIO) solvent. The NIO solvent is not the extract (i.e., the Ci - C 4 carboxylic acid to be separated). Rather, it is separate from and in addition to the lower carboxylic acid to be separated.

[0061] The extraction solvent may comprise two or more of the arylcarboxylate salts.

[0062] The NIO solvent is preferably selected to impart desirable physical properties to the extraction solvent, such as lower viscosity or higher hydrophobicity or to provide low-boiling azeotropes with water as described above and illustrated in, for example, U.S. Patent Nos. 1 ,861 ,841 ; 1 ,917,391 ; 2,028,800; 3,052,610; 5,662,780; 2,076, 184; and 2,204,616, to enable drying of the lower carboxylic acid in a subsequent purification step.

[0063] Examples of such hydrophobic NIO solvents include ketones, aromatic hydrocarbons, saturated hydrocarbons, ethers, esters, chlorinated hydrocarbons, nitriles, and higher carboxylic acids.

[0064] Fatty alcohols, such as nonanol, are not preferred as these may complicate the separation of the lower acids by forming esters during extraction or subsequent purification.

[0065] Likewise, care should be exercised when selecting specific compounds from any of the above classes of co-solvent, which, in combination with the lower acids or water, may form azeotropes or may be difficult to separate from the lower acids. [0066] Preferred non-ionic organic solvents form minimum-boiling azeotropes with water, but do not form azeotropes with the lower acid.

[0067] In one embodiment, the NIO solvent has 4 to 20 carbon atoms. In another embodiment, the NIO solvent has 4 to 18 carbon atoms. In other embodiments, the NIO solvent has 4 to 16 carbon atoms, 4 to 14 carbon atoms, 4 to 12 carbon atoms, 5 to 20 carbon atoms, 5 to 18 carbon atoms, 5 to 16 carbon atoms, 5 to 14 carbon atoms, or 5 to 12 carbon atoms.

[0068] In one particular embodiment, the NIO solvent comprises a higher carboxylic acid. As used herein, "higher carboxylic acids" refer to a carboxylic acid having 4 to 20 carbon atoms. The higher carboxylic acid may be straight-chained, branched, or aromatic. In the case where the carboxylic acid to be separated has 4 carbon atoms, the "higher carboxylic acid" contains at least 5 carbon atoms or has a sufficiently different boiling point (e.g., +/- 2°C) from the lower acid to be separated such that the two may be separated from one another by simple distillation. The higher carboxylic acid may contain additional functional groups, such as alkoxy, olefinic, and halogen.

[0069] In one embodiment, the higher carboxylic acid is selected from the group consisting of n-butyric acid, isobutyric acid, n-valeric acid, isovaleric acid, n-hexanoic acid, 2-ethylbutyric acid, heptanoic acid, n-octanoic, 2-ethylhexanoic acids, nonanoic acids, decanoic acids, dodecanoic acids, stearic acid, oleic acid, linolenic acid, and mixed vegetable-derived acids.

[0070] In another embodiment, the higher carboxylic acid is selected from the group consisting of n-butyric acid, isobutyric acid, n-valeric acid, isovaleric acid, n-hexanoic acid, 2-ethylbutyric acid, heptanoic acid, n-octanoic acid, and 2-ethylhexanoic acid.

[0071] In yet another embodiment, the higher carboxylic acid is selected from the group consisting of benzoic acid, 4-methylaminobenzoic acid, trifluoromethoxybenzoic acid, and 3-dimethylaminobenzoic acid.

[0072] Preferred NIO esters are those containing four to six carbon atoms such as ethyl acetate, n-propyl acetate, n-propyl formate, i-propyl acetate, i-propyl formate, n- butyl acetate, n-butyl formate, i-butyl acetate, i-butyl formate, n-propyl propionate, and i- propyl propionate. [0073] Preferred NIO ketones are those containing five to nine carbon atoms such as 2-pentanone, 3-pentanone, 3-methyl-2-butanone, 2-hexanone, 2-heptanone,

cyclohexanone, 4-methyl-2-pentanone, 2,4-dimethyl-3-pentanone, 5-methyl-2- hexanone, 4-heptanone, 2-octanone, 5-nonanone, 2,8-dimethyl-4-heptanone, 3,3,5- trimethyl cyclohexanone, and isophorone.

[0074] Preferred NIO ethers are those containing four to eight carbon atoms such as diethyl ether, methyl propyl ether, dipropyl ether, di-isopropyl ether, methyl tert butyl ether, tertiary amyl methyl ether, and ethyl butyl ether.

[0075] Preferred NIO aromatic hydrocarbons include toluene, m-xylene, p-xylene, and o-xylene.

[0076] Preferred NIO chlorinated hydrocarbons include methylene chloride,

chloroform, dichloroethane, ethylene chloride, carbon tetrachloride, and chlorinated derivatives of benzene.

[0077] Preferred NIO nitriles include valeronitrile and nitriles that are higher boiling than valeronitrile, such as hexanenitrile and benzonitrile.

[0078] In one embodiment, the hydrophobic NIO solvent is selected from the group consisting of methyl isobutyl ketone, toluene, isopropyl acetate, and methyl t-butyl ether.

[0079] In another embodiment, the hydrophobic NIO solvent is a fatty carboxylic acid, such as butyric, pentanoic, hexanoic, heptanoic, octanoic, nonanoic acids, and isomeric forms of C4-C9 carboxylic acids.

[0080] The extraction solvent according to the invention and compositions containing the same may include two or more of the NIO solvents. Desirable physical properties of the claimed systems may best be achieved by employing mixtures of the hydrophobic solvents.

[0081] The extraction solvent of the invention may comprise from 0 to 90, 10 to 90, 20 to 90, 30 to 90, 40 to 90, or 50 to 90 weight percent of the NIO solvent. The extraction solvent may also comprise from 0 to 80, 10 to 80, 20 to 80, 30 to 80, 40 to 80, or 50 to 80 weight percent of the NIO solvent. The extraction solvent may also comprise from 0 to 70, 10 to 70, 20 to 70, 30 to 70, 40 to 70, or 50 to 70 weight percent of the NIO solvent. The extraction solvent may also comprise from 0 to 60, 10 to 60, 20 to 60, 30 to 60, 40 to 60, or 50 to 60 weight percent of the NIO solvent. The extraction solvent may also comprise from 0 to 50, 10 to 50, 20 to 50, 30 to 50, or 40 to 50 weight percent of the NIO solvent. The balance of the extraction solvent may be composed of the arylcarboxylate salt according to the invention.

[0082] The NIO solvent may be combined with the arylcarboxylate salt before introduction into the extraction vessel. Alternatively, the NIO solvent may be introduced separately into the extraction vessel. In one embodiment, the NIO solvent may be introduced as a second solvent feed on the other side of the extraction cascade from the wet acid feed, such as in a fractional extraction mode, wherein the NIO solvent helps to wash any arylcarboxylate from the final raffinate product stream.

[0083] The arylcarboxylate or mixture of arylcarboxylates of the present invention may be mixed with one or more of the NIO solvents to form the extraction solvent in any known manner.

[0084] In a fourth aspect, the invention provides a composition B: r

B

[0085] Composition B comprises the arylcarboxylate salt according to formula 1 , the NIO solvent, a Ci to C 4 carboxylic acid, and water. It is useful for separating the lower carboxylic acid from water and optionally purifying the lower acid.

[0086] Composition B may contain more than one of the arylcarboxylate salt, more than one of the NIO solvent, and/or more than one of the lower acid. The

arylcarboxylate salt, NIO solvent, and lower acid may be any of those described herein.

[0087] In one embodiment, composition B has only two liquid phases.

[0088] A feature of composition B is that the Ci to C 4 carboxylic acid may be recovered by distillation at atmospheric pressure or lower. [0089] The weight ratio of the extraction solvent (arylcarboxylate and NIO solvent) to wet acid feed in composition B may vary over a wide range. For example, the ratio may range from 0.2 to 10: 1 or, more preferably, from 0.3 to 4: 1.

[0090] In a fifth aspect, the present invention provides a process for separating a Ci to C 4 carboxylic acid from water. The process includes the step of contacting a feed mixture comprising a Ci to C 4 carboxylic acid and water with an extraction solvent comprising a quaternary phosphonium arylcarboxylate salt according to the invention and a non-ionic organic solvent according to the invention at conditions effective to form (a) an extract mixture comprising the arylcarboxylate salt, the non-ionic organic solvent, and at least a portion of the Ci to C 4 carboxylic acid from the feed mixture and (b) a raffinate mixture comprising water and less of the Ci to C 4 carboxylic acid compared to the feed mixture.

[0091] The extraction of the feed mixture (i.e., the contacting step) can be carried out by any means known in the art to intimately contact two immiscible liquid phases and to separate the resulting phases after the extraction procedure. For example, the extraction can be carried out using columns, centrifuges, mixer-settlers, and

miscellaneous devices. Some representative examples of extractors include unagitated columns (e.g., spray, baffle tray and packed, perforated plate), agitated columns (e.g., pulsed, rotary agitated, and reciprocating plate), mixer-settlers (e.g., pump-settler, static mixer-settler, and agitated mixer-settler), centrifugal extractors (e.g., those produced by Robatel, Luwesta, deLaval, Dorr Oliver, Bird, CINC, and Podbielniak), and other miscellaneous extractors (e.g., emulsion phase contactor, electrically enhanced extractors, and membrane extractors). A description of these devices can be found in the "Handbook of Solvent Extraction," Krieger Publishing Company, Malabar, FL, pp. 275-501 (1991 ). The various types of extractors may be used alone or in any combination.

[0092] The extraction may be conducted in one or more stages. The number of extraction stages can be selected based on a number of factors, such as capital costs, achieving high extraction efficiency, ease of operability, the stability of the feed and the extraction solvent, and the extraction conditions. The extraction also can be conducted in a batch or continuous mode of operation. In a continuous mode, the extraction may be carried out in a co-current, a counter-current manner, or as a fractional extraction in which multiple solvents and/or solvent feed points are used to help facilitate the separation. The extraction process also can be conducted in a plurality of separation zones that can be in series or in parallel.

[0093] The extraction may be carried out at an extraction solven feed mixture weight ratio of, for example, 0.2 to 10: 1 or, more preferably, 0.3 to 4: 1 .

[0094] The extraction typically can be carried out at a temperature of 10 to 140°C. For example, the extraction can be conducted at a temperature of 30 to 1 10°C. The desired temperature range may be constrained further by the boiling point of the extractant components or water. Generally, it is undesirable to operate the extraction under conditions where the extractant boils. In one embodiment, the extractor can be operated to establish a temperature gradient across the extractor in order to improve the mass transfer kinetics or decantation rates.

[0095] If the temperature chosen for the extraction is greater than the normal boiling point of any of the lower acid to be extracted, any of the components comprising the extraction solvent, or water; then the extractor may be run under sufficient pressure to suppress boiling of any of aforementioned components. The extraction typically can be carried out at a pressure of 1 bara to 10 bara, or 1 bara to 5 bara.

[0096] The separation process according to the invention may further include the steps of separating the extract from the raffinate and recovering the Ci to C 4 carboxylic acid from the extract by distillation at atmospheric pressure or lower. Any known method from separating a liquid extract from a raffinate may be used. Likewise, any known distillation technique may be used to recover the lower acid from the extraction solvent.

[0097] In one embodiment, the present invention provides a process for separating acetic acid from water. The process comprises contacting a feed mixture comprising acetic acid and water with an extraction solvent comprising a quaternary phosphonium arylcarboxylate salt according to the invention at conditions effective to form (a) an extract mixture comprising the arylcarboxylate salt and at least a portion of the acetic acid from the feed mixture and (b) a raffinate mixture comprising water and less of the acetic acid compared to the feed mixture.

[0098] This acetic acid separation process may be carried out using any of the modes described herein above.

[0099] The extraction solvent used in this process may further comprise one or more of the NIO solvents according to the invention.

[0100] The acetic acid separation process may further include the steps of separating the extract mixture from the raffinate mixture and recovering the acetic acid from the extract mixture by distillation at atmospheric pressure or lower.

[0101] These additional steps may also be carried out as described herein above.

[0102] The present invention includes and expressly contemplates any and all combinations of embodiments, features, and/or ranges disclosed herein. That is, the invention may be defined by any combination of embodiments, features, and/or ranges mentioned herein.

[0103] As used herein, the indefinite articles "a" and "an" mean one or more, unless the context clearly suggests otherwise. Similarly, the singular form of nouns includes their plural form, and vice versa, unless the context clearly suggests otherwise.

[0104] As used herein, the term "and/or," when used in a list of two or more items, means that any one of the listed items can be employed by itself, or any combination of two or more of the listed items can be employed. For example, if a composition is described as containing components A, B, and/or C, the composition can contain A alone; B alone; C alone; A and B in combination; A and C in combination; B and C in combination; or A, B, and C in combination.

[0105] While attempts have been made to be precise, the numerical values and ranges described herein should be considered to be approximations (even when not qualified by the term "about"). These values and ranges may vary from their stated numbers depending upon the desired properties sought to be obtained by the present invention as well as the variations resulting from the standard deviation found in the measuring techniques. Moreover, the ranges described herein are intended and specifically contemplated to include all sub-ranges and values within the stated ranges. For example, a range of 50 to 100 is intended to describe and include all values within the range including sub-ranges such as 60 to 90 and 70 to 80.

[0106] The content of all documents cited herein, including patents as well as nonpatent literature, is hereby incorporated by reference in their entirety. To the extent that any incorporated subject matter contradicts with any disclosure herein, the disclosure herein shall take precedence over the incorporated content.

[0107] This invention can be further illustrated by the following examples of preferred embodiments thereof, although it will be understood that these examples are included merely for purposes of illustration and are not intended to limit the scope of the invention.

EXAMPLES

[0108] Abbreviations used in the following examples are summarized in Table 1 .

Table 1

Abbreviations

Compound Abbreviation

2-heptanone MAK

2-pentanone MPK

tributyl phosphate TBP

triethylhexyl phosphate TEHP

Cyanex 923: a mixture trialkyl phosphine oxides with octyl and hexyl groups C923

1 -ethyl-3-methyl imidazolium bis(trifluoromethylsulfonyl)imide emim-NTf 2

1 -butyl-3-methyl imidazolium bis(trifluoromethylsulfonyl)imide bmim-NTf 2

1 -butyl-3-methyl imidazolium acetate bmim-OAc

1 -butyl-3-methyl imidazolium bis(trifluoroethylsulfonyl)imide bmim-BETI

1 -butyl-3-methyl imidazolium tris(pentafluoroethyl)trifluorophosphate bmim-FAP

1 -hexyl-3-methyl imidazolium bis(trifluoromethylsulfonyl)imide hmim-NTf 2

1 -octyl-3-methyl imidazolium bis(trifluoromethylsulfonyl)imide omim-NTf 2

1 -octyl-3-methyl imidazolium bis(trifluoroethylsulfonyl)imide omim-BETI

1 -decyl-3-methyl imidazolium bis(trifluoromethylsulfonyl)imide C 0 mim-NTf 2

1 -butyl-2,3-dimethyl imidazolium bis(trifluoromethylsulfonyl)imide C 4 mmim-NTf 2

1 -(2-methoxyethyl)-3-methyl imidazolium

MeOEtmim-FAP tris(pentafluoroethyl)trifluorophosphate

1 -(8-hydroxyoctyl)-3-methylimidazolium bis(trifluoromethylsulfonyl)imide HOC 8 mim-NTf 2 iPr 2 N(CH 2 ) 2 mim- dimethylaminoethyl-dimethylethylammonium bis(trifluoromethyl)sulfonylimide

NTf 2

1 -butyl pyridinium bis(trifluoromethylsulfonyl)imide bpyr-NTf 2

1 -(2-methoxyethyl)-pyridinium tris(pentafluoroethyl)trifluorophosphate MeOEtpyr-FAP

1 -(4-cyanobutyl)-3-methyl imidazolium bis(trifluoromethylsulfonyl)imide (4-CN)bmim-NTf 2 trimethyl(butyl)ammonium bis(trifluoromethylsulfonyl)imide N 4 -NTf 2 trimethyl(octyl)ammonium bis(trifluoromethylsulfonyl)imide N 8 -NTf 2

1 -(2-diisopropylaminoethyl) dimethylethylammonium iPr 2 N(CH 2 ) 2 N 211 - bis(trifluoromethyl)sulfonylimide NTf 2

Me 2 N(CH 2 ) 2 N 211 - dimethylaminoethyl-dimethylethylammonium bis(trifluoromethyl)sulfonylimide

NTf 2

choline bis(trifluoromethylsulfonyl)imide choline-NTf 2

1 -butyl-1 -methyl pyrrolidinium bis(trifluoromethylsulfonyl)imide C4mpyrr-NTf 2

N-trimethylbetainium bis(trifluoromethylsulfonyl)imide C ! Hbet-NTfz triethyl(octyl)phosphonium bis(trifluoromethylsulfonyl)imide P2228"NTf2 tribuytl(ethyl)phosphonium diethylphosphate P 4 442-0 2 P(OEt)2 Compound Abbreviation trioctyl(methyl)phosphonium bis(trifluoromethylsulfonyl)imide "NTf 2

1 -(2-diisopropylaminoethyl) trioctylphosphonium iPr 2 N(CH bis(trifluoromethyl)sulfonylimide NTf 2

trihexyl(tetradecyl)phosphonium chloride .14-CI trihexyl(tetradecyl)phosphonium hydroxide ,14-ΟΗ trihexyl(tetradecyl)phosphonium bis(trifluoromethylsulfonyl)imide ,14"NTf 2 trihexyl(tetradecyl)phosphonium tris(pentafluoroethyl)trifluorophosphate ,14"FAP trihexyl(tetradecyl)phosphonium benzoate ,14-ΒΖ trihexyl(tetradecyl)phosphonium 4-methylamino benzoate P 6 66,i4-4-MABz trihexyl(tetradecyl)phosphonium 4-trifluoromethoxy benzoate P 6 66.i4-4-CF 3 OBz trihexyl(tetradecyl)phosphonium 2-nitrobenzoate P 6 66.i4-2-N0 2 Bz trihexyl(tetradecyl)phosphonium pentafluorobenzoate ,14-FsBZ trihexyl(tetradecyl)phosphonium 3-dimethylaminobenzoate P 666, 4 -3-DMABz trioctyl(methyl)phosphonium hydroxide -ΟΗ trioctyl(methyl)phosphonium 4-methylaminobenzoate P 8 88i-MABz

Example 1

Synthesis of Ρβββ . η-ΟΗ

[0109] A column was packed with 100 cm 3 ion exchange resin (Amberlite IRN-78, OH-form), and the resin was washed with methanol to moisten it sufficiently and to remove air from the resin. Approximately 50 g of P666 , u-CI was mixed with 20 cm 3 methanol. The mixture was poured slowly into the column and flowed through the resin. The eluent containing methanol, Ρβββ , η-ΟΗ, and some P666 , u-CI was passed through the column three times to completely replace the halide anion with hydroxide. Then, the resin was washed with methanol several times to wash out all of the P 6 66 , u-OH. The solution was then placed in a rotary evaporator to remove most of the solvent and then dried under high vacuum to remove residual methanol and water. Example 2

Synthesis of Phosphonium Benzoates

[0110] Arylcarboxylate phosphonium salts were prepared by an acid-base

neutralization reaction of the Ρβββ , η-ΟΗ from Example 1 .

[0111] For instance, 25.97 g of Ρβββ , η-ΟΗ (0.05 mole, prepared as in Example 1 ) was dissolved in approximately 50 mL methanol in a 250 ml round-bottomed flask. Benzoic acid (6.1 1 g, 0.05 moles) was added to the flask, and the mixture stirred overnight at room temperature. The flask was then placed on a rotary evaporator, and the volatiles removed at reduced pressure, first at ambient temperature and then heated at 100°C under a high vacuum to remove residual water and solvent.

[0112] In the same way, 4-methylaminobenzoic acid (7.56 g), 4- dimethylaminobenzoic acid (8.26 g), 4-trifluoromethoxybenzoic acid (9.66 g), 2- nitrobenzoic acid(8.36 g), and pentafluorobenzoic acid (10.85 g) were also individually combined with aliquots of Ρβββ,η-ΟΗ (0.05 mole) to produce the corresponding Peee.u- arylcarboxylate phosphonium salts.

[0113] All these arylcarboxylate phosphonium salts were characterized by 1 H NMR spectra with purity above 90%.

[0114] The 1 H NMR spectra were obtained in CDCI3 to verify their structures and are reported in Table 2 and displayed in Figures 1 -6.

Table 2

1 H NMR Characterization of Phosphonium Arylcarboxylates

a Spectra obtained in CDCI 3 .

Example 3

Extraction of Acetic Acid Using Representative NIO Solvents

[0115] Tie line data at both high (typically around 16-20 wt% of HOAc in the organic phase) and low acetic acid concentrations (typically around 1 to 5 wt% of HOAc in the organic phase) were measured for each solvent at the temperature given in Table 3.

[0116] Roughly equal masses of water and solvent were added to a glass vial. Acetic acid was added to the solvent-water mixture in amounts sufficient to yield either high or low acid concentration data. Once the acetic acid was added, the mixture was agitated vigorously, and subsequently was allowed to separate into clear phases while maintaining the specified temperature. Each phase was sampled and analyzed by gas chromatography for water and acetic acid weight percent. These data were used to calculate partition coefficients, with the controlling partition coefficient, P CO nt, taken as the lesser of the partition coefficients at high and low acid concentrations. The data were also used to calculate the water to acetic acid weight ratio at high acid concentration, R ex tr. Results are given in Table 3.

Table 3

Acetic Acid Extraction Factors of Non-ionic Organic Solvents

Data taken from J. Chem. Eng. Data, Vol. 46, pp. 1450-56 (2001).

[0117] Although PrCN has a relatively high extraction factor, it has the same boiling point as acetic acid, forms an azeotrope with acetic acid, and is thus very difficult to separate from acetic acid.

Example 4

Extraction of Acetic Acid Using Phosphate Ester Solvents

[0118] Tie line data at both high (typically around 15-20 wt% of HOAc in the organic phase) and low acetic acid concentrations (typically around 1 to 2 wt% of HOAc in the organic phase) were measured for each solvent (either a pure phosphate ester or a mixture of phosphate ester with a NIO solvent) at the temperature given in Table 4.

[0119] Roughly equal masses of water and solvent were added to a glass vial. Acetic acid was added to the solvent-water mixture in amounts sufficient to yield either high or low acid concentration data. Once the acetic acid was added, the mixture was agitated vigorously, and subsequently was allowed to separate into clear phases while maintaining the specified temperature. Each phase was sampled and analyzed by gas chromatography for water and acetic acid weight percent. These data were used to calculate partition coefficients, with the controlling partition coefficient, P CO nt, taken as the lesser of the partition coefficients at high and low acid concentrations. The data were also used to calculate the water to acetic acid weight ratio at high acid

concentration, R ex tr. Results are given in Table 4.

Table 4

Acetic Acid Extraction by Phosphate-Ester-Containing Compositions at 40°C

[0120] As expected from Wardell and King ("Solvent Equilibria for Extraction of Carboxylic Acids from Water," J. Chem. and Eng. Data, Vol. 23, No. 2, pp. 144-148 (1978)), the extraction factors for phosphate ester solvents are somewhat improved over those of NIO solvents.

Example 5

Extraction of Acetic Acid Using Cyanex 923

[0121] Tie line data at both high (typically around 15-20 wt% of HOAc in the organic phase) and low acetic acid concentrations (typically around 1 to 2 wt% of HOAc in the organic phase) were measured for each solvent (either commercially available Cyanex 923 or a mixture of Cyanex 923 with a non-ionic organic solvent) at the temperature given in Table 5.

[0122] Roughly equal masses of water and solvent were added to a glass vial. Acetic acid was added to the solvent-water mixture in amounts sufficient to yield either high or low acid concentration data. Once the acetic acid was added, the mixture was agitated vigorously, and subsequently was allowed to separate into clear phases while maintaining the specified temperature. Each phase was sampled and analyzed by gas chromatography for water and acetic acid weight percent. These data were used to calculate partition coefficients, with the controlling partition coefficient, P CO nt, taken as the lesser of the partition coefficients at high and low acid concentrations. The data were also used to calculate the water to acetic acid weight ratio at high acid

concentration, R ex tr. Results are given in Table 5.

Table 5

Acetic Acid Extraction Factors for Cyanex-Containing Compostions at 40°C

Example 6

Extraction of Acetic Acid Using Hydrophobic Liquid Salts

[0123] Tie line data at both high (typically around 7-25 wt% of HOAc in the organic phase) and low acetic acid concentrations (typically around 0.2 to 5 wt% of HOAc in the organic phase) were measured for each solvent at the temperature specified in Table 6.

[0124] Some solvents showed extremely low acid partition coefficients, and the two- phase region did not extend much above about 7 wt% of acetic acid. Equilibrium data were measured for each compound in the following manner. [0125] Three grams of the solvent were pipetted into a jacketed glass cell, wherein three grams of an aqueous mixture of acetic acid (prepared to yield either high or low acid concentration data) were added. A stir bar was introduced to the vial and the contents sealed with a plastic cap and a layer of parafilm tape. The cell was maintained at the desired temperature by means of a thermostatted fluid circulating through the cell jacket. The mixture was agitated vigorously for 1 .5 hours and then allowed to separate into clear phases while maintaining the specified temperature without stirring. After a six hour settling time, each phase was sampled and analyzed by NMR for water and acetic acid weight percent. These data were used to calculate partition coefficients, with the controlling partition coefficient, P CO nt, taken as the lesser of the partition coefficients at high and low acid concentrations. The data were also used to calculate the water to acetic acid weight ratio at high acid concentration, R ex tr. Results are given in Table 6.

Table 6

Extraction of Acetic Acid in a Selection of Hydrophobic Solvents at 20°C

qu ra on a ra er an .

Example 7

Extraction of Acetic Acid Using Tetraalkylphosphonium Arylcarboxylates

[0126] Tie line data at both high (typically around 9-21 wt% of HOAc in the organic phase) and low acetic acid concentrations (typically around 1 to 3 wt% of HOAc in the organic phase) were measured at 20°C for each solvent listed in Table 7. Equilibrium data were measured for each solvent in the following manner.

[0127] Three grams of solvent were pipetted into a jacketed glass cell, followed by three grams of an aqueous mixture of acetic acid (prepared to yield either high or low acid concentration data). A stir bar was introduced to the vial, and the contents were sealed with a plastic cap and a layer of parafilm tape. The cell was maintained at the desired temperature by means of a thermostatted fluid circulating through the cell jacket. The mixture was agitated vigorously for 1 .5 hours and then allowed to separate into clear phases while maintaining the specified temperature without stirring. After a six hour settling time, each phase was sampled and analyzed by NMR for water and acetic acid weight percent. [0128] These data were used to calculate partition coefficients, with the controlling partition coefficient, P CO nt, taken as the lesser of the partition coefficients at high and low acid concentrations. The data were also used to calculate the water to acetic acid weight ratio at high acid concentration, R ex tr. Results are given in Table 7.

Table 7

Acetic Acid Extraction by Different Phosphonium Arylcarboxylates at 20°C

Example 8

Effect of Temperature on Extraction of Acetic Acid Using NIO Solvents

[0129] Tie line data were measured at 22 and 40°C for each solvent listed in Table 8.

[0130] Roughly equal masses of water and solvent were added to a glass vial. Acetic acid was added to the solvent-water mixture in amounts sufficient to yield either high or low acid concentration data. Once the acetic acid was added, the mixture was agitated vigorously, and subsequently was allowed to separate into clear phases while maintaining the specified temperature. Each phase was sampled and analyzed by gas chromatography for water and acetic acid weight percent. These data were used to calculate partition coefficients, with the controlling partition coefficient, P CO nt, taken as the lesser of the partition coefficients at high and low acid concentrations. Results are given in Table 8. Table 8

Effect of Temperature on Acetic Acid Partitioning by NIO Solvents

[0131] As seen from Table 8, the partition coefficient and extraction factor responds in different ways to changes in temperature in different NIO solvents.

Example 9

Effect of Temperature on Extraction of Acetic Acid Using Phosphonium Benzoates

[0132] Tie line data were measured at 20 and 75°C for each solvent listed in Table 9. Eguilibrium data were measured for each solvent in the following manner.

[0133] Three grams of solvent were pipetted into a jacketed glass cell, followed by three grams of an aqueous mixture of acetic acid (prepared to yield either high or low acid concentration data). A stir bar was introduced to the vial, and the contents sealed with a plastic cap and a layer of parafilm tape. The cell was maintained at the desired temperature by means of a thermostatted fluid circulating through the cell jacket. The mixture was agitated vigorously for 1.5 hours and then allowed to separate into clear phases while maintaining the specified temperature without stirring. After a six hour settling time, each phase was sampled and analyzed by NMR for water and acetic acid weight percent.

[0134] These data were used to calculate partition coefficients, with the controlling partition coefficient, P CO nt, taken as the lesser of the partition coefficients at high and low acid concentrations. The data were also used to calculate the water to acetic acid weight ratio at high acid concentration, R ex tr. Results are given in Table 9. Table 9

Effect of Temperature on Acetic Acid Partitioning by Phosphonium Benzoates

[0135] As with NIO solvents (see Table 8), the partition coefficients and extraction factors both increase and decrease with respect to temperature in different phosphonium benzoate solvents (see Table 9). It is notable that, in some cases, the extraction factor increases with increasing temperature.

[0136] The invention has been described in detail with particular reference to preferred embodiments thereof, but it will be understood that variations and modifications can be effected within the spirit and scope of the invention.