QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON

Title:

QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON

Document Type and Number:

WIPO Patent Application WO2004000197

Kind Code:

A3

Abstract:

The invention provides a composition useful for making oral dosage forms capable of dissolving un the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%, wherein the composition includes liquiflash particles and an excipient mass. according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of directly compressible inorganic salt and a cellulose derivative. Preferably,, the liquiflash particles and the excipient mass are combined in porportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness aand friability.

Inventors:

MEZAACHE NAIMA (US)
FRISBEE STEVEN (US)
WOODALL PATRICK (US)
HERMAN MARK (US)

Application Number:

PCT/US2003/019527

Publication Date:

March 24, 2005

Filing Date:

June 23, 2003

Export Citation:

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Assignee:

BIOVAIL LAB INC (BB)
MEZAACHE NAIMA (US)
FRISBEE STEVEN (US)
WOODALL PATRICK (US)
HERMAN MARK (US)

International Classes:

A61J1/03; A61K9/00; A61K9/14; A61K9/16; A61K9/20; A61K9/48; A61K31/138; A61K31/366; A61K31/426; A61K31/437; A61K31/4525; A61K45/00; A61K47/02; A61K47/10; A61K47/26; A61K47/32; A61K47/38; A61K47/46; A61P25/20; A61P25/24; A61P43/00; A61K9/50; (IPC1-7): A61K9/20

Foreign References:

US5871781A

1999-02-16

Other References: