Title:
QUINAZOLINE-BASED COMPOUND, COMPOSITION, AND APPLICATION OF QUINAZOLINE-BASED COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/194265
Kind Code:
A1
Abstract:
Provided are a quinazoline-based compound, a composition, and an application of the quinazoline-based compound, in particular, relating to a compound represented by formula (I), a stereoisomer thereof, a pharmaceutically acceptable salt or deuterated derivative thereof, a composition thereof, and an application thereof in the preparation of a drug that serves as a tyrosine kinase inhibitor. The compound has good inhibitory activity against EGFR, HER2 kinase, and their exon 20 mutations and EGFRviii mutations.
Inventors:
ZHANG QIANG (CN)
YANG LEIFU (CN)
YANG LEIFU (CN)
Application Number:
PCT/CN2022/081599
Publication Date:
September 22, 2022
Filing Date:
March 18, 2022
Export Citation:
Assignee:
BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN)
International Classes:
C07D239/94; A61K31/517; A61P1/06; A61P9/10; A61P17/00; A61P17/06; A61P17/14; A61P19/02; A61P27/02; A61P35/00; A61P35/02; A61P37/02; C07D401/14
Domestic Patent References:
| WO2020057511A1 | 2020-03-26 |
Foreign References:
| CN104736155A | 2015-06-24 | |||
| CN104119350A | 2014-10-29 | |||
| CN102471312A | 2012-05-23 |
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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