Title:
QUINAZOLINE COMPOUNDS USEFUL AS P38 KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2004092144
Kind Code:
A3
Abstract:
The present invention relates to compounds of formula (I), wherein R4, R5, R6, R7, Q, m and n are as defined in the specification. The compounds are useful as p38 kinase inhibitors, and therefore, may be used for treatment of p38-mediated disorder.
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Inventors:
DUNN JAMES PATRICK (US)
GOLDSTEIN DAVID MICHAEL (US)
STAHL CHRISTOPH MARTIN (DE)
TREJO-MARTIN TERESA ALEJANDRA (US)
GOLDSTEIN DAVID MICHAEL (US)
STAHL CHRISTOPH MARTIN (DE)
TREJO-MARTIN TERESA ALEJANDRA (US)
Application Number:
PCT/EP2004/003779
Publication Date:
March 24, 2005
Filing Date:
April 08, 2004
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
DUNN JAMES PATRICK (US)
GOLDSTEIN DAVID MICHAEL (US)
STAHL CHRISTOPH MARTIN (DE)
TREJO-MARTIN TERESA ALEJANDRA (US)
DUNN JAMES PATRICK (US)
GOLDSTEIN DAVID MICHAEL (US)
STAHL CHRISTOPH MARTIN (DE)
TREJO-MARTIN TERESA ALEJANDRA (US)
International Classes:
A61P19/02; C07D239/84; C07D401/12; C07D405/12; (IPC1-7): C07D239/84; C07D403/12; C07D407/12; A61K31/517; A61P19/02
Domestic Patent References:
| WO2001038315A1 | 2001-05-31 | |||
| WO1992007844A1 | 1992-05-14 |
Foreign References:
| US6476031B1 | 2002-11-05 | |||
| GB1024908A | 1966-04-06 | |||
| EP1052254A1 | 2000-11-15 |
Other References:
SHEWCHUK L ET AL: "Binding Mode of the 4-anilinoquinazoline Class of Protein Kinase Inhibitor: X-ray Crystallographic Studies of 4-Anilinoquinazolines Bound to Cyclin-Dependent Kinase 2 and p38 Kinase", J. MED. CHEM., vol. 43, 2000, pages 133 - 138, XP002293111
WANDEL C ET AL: "P-GLYCOPROTEIN AND CYTOCHROME P-450 3A INHIBITION: DISSOCIATION OF INHIBITORY POTENCIES", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 16, 15 August 1999 (1999-08-15), pages 3944 - 3948, XP000971608, ISSN: 0008-5472
WEBB T R ET AL: "Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2b receptors", BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 11, no. 1, 1 January 2003 (2003-01-01), pages 77 - 85, XP002305821
HESS H J ET AL: "Antihypertensive 2-amino-4(3H)-quinazolines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 11, no. 1, 1968, pages 130 - 136, XP002305822
WANDEL C ET AL: "P-GLYCOPROTEIN AND CYTOCHROME P-450 3A INHIBITION: DISSOCIATION OF INHIBITORY POTENCIES", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 16, 15 August 1999 (1999-08-15), pages 3944 - 3948, XP000971608, ISSN: 0008-5472
WEBB T R ET AL: "Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2b receptors", BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 11, no. 1, 1 January 2003 (2003-01-01), pages 77 - 85, XP002305821
HESS H J ET AL: "Antihypertensive 2-amino-4(3H)-quinazolines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 11, no. 1, 1968, pages 130 - 136, XP002305822
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