QUINAZOLINE DERIVATIVE OR ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Title:

QUINAZOLINE DERIVATIVE OR ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Document Type and Number:

WIPO Patent Application WO/2017/188720

Kind Code:

A3

Abstract:

The present invention provides a quinazoline derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The quinazoline derivative or its pharmaceutically acceptable salt has a selective inhibitory activity against the phosphatidylinositol 3-kinase delta subunit, and therefore can be usefully applied for preventing or treating cancer, along with avoiding side effects such as lymphopenia-associated inflammatory responses.

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Inventors:

KIM YOUNG-HWAN (KR)
HAN TAE-DONG (KR)
KIM DONG-HOON (KR)
JUNG EUN-HYE (KR)
CHOI SU-BIN (KR)
LEE EUI-CHUL (KR)
CHONG WON-EE (KR)
PARK JIN-HWI (KR)
PARK JUN-CHUL (KR)
KANG HO-WOONG (KR)
GAL JI-YEONG (KR)
PARK CHAN-SUN (KR)
KIM JONG-GYUN (KR)
NAM SU-YOUN (KR)

Application Number:

PCT/KR2017/004424

Publication Date:

July 26, 2018

Filing Date:

April 26, 2017

Export Citation:

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Assignee:

YUHAN CORP (KR)

International Classes:

C07D239/72; A61K31/506; A61K31/517; C07D403/04

Domestic Patent References:

WO2015168079A1

2015-11-05

Foreign References:

US20130029982A1	2013-01-31
US20130225557A1	2013-08-29
US20140051699A1	2014-02-20
US20140011819A1	2014-01-09

Other References: