QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF

WIPO Patent Application WO/2023/226323

A1

The present invention relates to the technical field of chemical medicine, and in particular to a quinazoline derivative, and a preparation method therefor and the use thereof. The quinazoline derivative provided by the present invention has a structure as shown in a formula I. The quinazoline derivative of the present invention can inhibit the activities of kinases VEGFR1, VEGFR2 and VEGFR3 at a low nanomolar concentration, and can inhibit the activities of VEGFRs in a dose-dependent manner; and it is verified by means of in vivo anti-tumor experiments that the quinazoline derivative shows an effect of effectively inhibiting the growth of colorectal cancer.

YANG CHENG (US)
YANG GUANG (CN)
ZHOU HONGGANG (CN)

PCT/CN2022/131932

November 30, 2023

November 15, 2022

Click for automatic bibliography generation  

TIANJIN JIKUN MEDICAL TECH CO LTD (CN)

C07D239/88; A61P35/00; C07D401/12; C07D403/12; C07D405/12; C07D413/12

CN114920703A	2022-08-19
EP1925676A1	2008-05-28
US20180133225A1	2018-05-17
CN108341813A	2018-07-31
CN103304572A	2013-09-18
CN106478621A	2017-03-08

RAVEZ SÉVERINE ET AL.: "Inhibition of Tumor Cell Growth and Angiogenesis by 7-Aminoalkoxy-4-Aryloxy-Quinazoline Ureas, a Novel Series of Multi-Tyrosine Kinase Inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 79, 5 April 2014 (2014-04-05), XP028652720, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.04.007
TONG MAO -GUO: "Research Advances in Synthesis and Antitumor Activity of Quinazoline Derivatives", GUANGZHOU CHEMICAL INDUSTRY, vol. 40, no. 3, 8 February 2012 (2012-02-08), pages 17 - 19, XP093111225

BEIJING GAOWO LAW FIRM (CN)

View/Download PDF      PDF Help

Previous Patent: MECHANISM- AND DATA DRIVING-BASED ENGINE CYLINDER HEAD MILLED SURFACE QUALITY PREDICTION METHOD

Next Patent: METHOD FOR ALLOCATING FIRST OBJECT, AND APPARATUS, STORAGE MEDIUM AND ELECTRONIC APPARATUS