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Patent Searching and Data


Title:
QUINAZOLINONE PARP-1 INHIBITOR AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/128036
Kind Code:
A1
Abstract:
Disclosed are a new class of quinazoline-2,4 (1H, 3H)-diketone PARP-1 inhibitors, and a preparation method and pharmaceutical composition and a use thereof. In particular, the present invention relates to a quinazoline-2,4 (1H, 3H)-diketone derivative as shown in general formula I and a stereoisomer thereof, pharmaceutically acceptable salts thereof, and a preparation method thereof, a composition comprising one or more of such compounds, and a use of such compounds in the preparation of drugs for preventing and/or treating tumours.

Inventors:
XU BAILING (CN)
CHEN XIAOGUANG (CN)
YAO HAIPING (CN)
JI MING (CN)
JIN JING (CN)
ZHOU JIE (CN)
WANG KE (CN)
ZHAO DALONG (CN)
Application Number:
CN2016/072135
Publication Date:
August 03, 2017
Filing Date:
January 26, 2016
Export Citation:
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Assignee:
INST OF MATARIA MEDICA CHINESE ACAD OF MEDICAL SCIENCES (CN)
BEIJNG COLLAB PHARMA CO LTD (CN)
International Classes:
C07D403/10; A61K31/517; A61K31/5377; A61K31/541; A61P35/00; C07D239/96; C07D401/10
Foreign References:
CN102731416A2012-10-17
CN103443085A2013-12-11
CN105461697A2016-04-06
Attorney, Agent or Firm:
BEIJING SAN GAO YONG XIN INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
北京三高永信知识产权代理有限责任公司 (CN)
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