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Title:
QUINOID CHALCONE C-GLYCOSIDE DIMER COMPOUND HAVING ANTI-TUMOR ACTIVITY AND ANTI-INFLAMMATORY ACTIVITY AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2017/219510
Kind Code:
A1
Abstract:
A quinoid chalcone c-glycoside dimer compound having an anti-tumor activity and an anti-inflammatory activity and a method for preparing same. The compound is a quinoid chalcone c-glycoside dimer compound separated from Carthamus tinctorius, the quinone ring being 1,5-cyclohexadienone. An anti-inflammatory and anti-tumor activity research shows that the compound has an anti-inflammatory activity and an anti-tumor activity against various tumors, and can inhibit DNA topoisomerase I. Moreover, a toxicity experiment study shows that the quinoid chalcone and flavonol conjugate has low toxicity.

Inventors:
TANG YUPING (CN)
DUAN JINAO (CN)
LE SHIJUN (CN)
Application Number:
CN2016/098655
Publication Date:
December 28, 2017
Filing Date:
September 12, 2016
Export Citation:
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Assignee:
UNIV NANJING CHINESE MEDICINE (CN)
International Classes:
C07H19/01; A61K31/351; A61P7/02; A61P29/00; A61P35/00; C07D309/10
Foreign References:
Other References:
KAZUMA, K. ET AL.: "Quinochalcones and Flavonoids from Fresh Florets in Different Cultivars of Carthamustinctorius L.", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 64, no. 8, 31 December 2000 (2000-12-31), pages 1588 - 1599, XP009186107, ISSN: 0916-8451
HU , XIOAJIA ET AL.: "Chemical Constituents and Pharmacological Activities of CarthamusTinctorius L.", J OURNAL OF PHARMACEUTICAL PRACTICE, vol. 31, no. 3, 25 May 2013 (2013-05-25), pages 161 - 168
LE, SHIJUN ET AL.: "Separation and Evaluation of Antioxidant Constituents from CarthamusTinctorius", CHINA JOURNAL OF CHINESE MATERIA MEDICA, vol. 39, no. 17, 30 September 2014 (2014-09-30), pages 3295 - 3300, XP055442932, ISSN: 1001-5302
MESELHY, M.R. ET AL.: "Two New Quinochalcone Yellow Pigments from Carthamustinctorius and Ca2+ Antagonistic Activity of Tinctormine", CHEM. PHARM. BULL, vol. 41, 10 January 1993 (1993-01-10), pages 1796 - 1802, XP055214387, ISSN: 0009-2363
JIANG,JIANSHUANGET ET AL.: "Two New Quinochalcones from the Florets of Carthamustinctorius", ORGANIC LETTERS, vol. 12, no. 6, 19 February 2010 (2010-02-19), pages 1196 - 1199, XP055214401, ISSN: 1523-7060
Attorney, Agent or Firm:
NANJING JINGWEI PATENT & TRADEMARK AGENCY CO., LTD (CN)
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