Title:
QUINOLINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2015/012298
Kind Code:
A1
Abstract:
A compound represented by general formula (I)
(I)
has a strong Axl inhibiting activity by introducing a distinctive bicyclic structure in which a saturated carbocyclic ring is fused to a pyridone ring, and thus may be used as a therapeutic agent for Axl related diseases such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, cancer such as glioma, kidney disease, immune system disease, and circulatory system disease.
Inventors:
INUKAI TAKAYUKI (JP)
TAKEUCHI JUN (JP)
YASUHIRO TOMOKO (JP)
TAKEUCHI JUN (JP)
YASUHIRO TOMOKO (JP)
Application Number:
PCT/JP2014/069419
Publication Date:
January 29, 2015
Filing Date:
July 23, 2014
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
C07D215/54; A61K31/4709; A61K31/5377; A61P9/00; A61P13/12; A61P25/02; A61P35/00; A61P35/04; A61P37/02; A61P43/00; C07D401/14
Domestic Patent References:
| WO2013074633A1 | 2013-05-23 | |||
| WO2012011548A1 | 2012-01-26 | |||
| WO2012028332A1 | 2012-03-08 | |||
| WO2009137429A1 | 2009-11-12 | |||
| WO2007146824A2 | 2007-12-21 | |||
| WO2006116713A1 | 2006-11-02 | |||
| WO2012028332A1 | 2012-03-08 | |||
| WO2013074633A1 | 2013-05-23 | |||
| WO2012011548A1 | 2012-01-26 | |||
| WO2006116713A1 | 2006-11-02 | |||
| WO2007146824A2 | 2007-12-21 |
Other References:
DATABASE REGISTRY [online] 16 January 2001 (2001-01-16), "3-QUINOLINECARBOXAMIDE, N-[5-[(7-CHLORO-4-QUINOLINYL)THIO]-1,3,4- THIADIAZOL-2-YL]-1,2-DIHYDRO-4-HYDROXY-2-OXO- (CA INDEX NAME)", XP055311240, retrieved from STN Database accession no. 314026-41-0
CLINICAL SCIENCE, vol. 122, 2012, pages 361 - 368
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 107, no. 3, 2010, pages 1124 - 1129
BLOOD, vol. 121, 2013, pages 2064 - 2073
"Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Medicaments", pages: 163 - 198
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC
ORGANIC LETTERS, vol. 3, no. 17, 2001, pages 2729 - 2732
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, WILEY
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
HYPERTENSION, vol. 39, 2002, pages 1095 - 1100
See also references of EP 3026045A4
CLINICAL SCIENCE, vol. 122, 2012, pages 361 - 368
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 107, no. 3, 2010, pages 1124 - 1129
BLOOD, vol. 121, 2013, pages 2064 - 2073
"Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Medicaments", pages: 163 - 198
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY & SONS INC
ORGANIC LETTERS, vol. 3, no. 17, 2001, pages 2729 - 2732
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, WILEY
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
HYPERTENSION, vol. 39, 2002, pages 1095 - 1100
See also references of EP 3026045A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
Download PDF: