Title:
QUINOLINE DERIVATIVES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2006088541
Kind Code:
A3
Abstract:
This disclosure provides a new class of compounds referred to as "reversed chloroquines" (RCQs), which are highly effective against CQR and CQS malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQR reversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQR or CQS Plasmodium
Inventors:
PEYTON DAVID H (US)
BURGESS STEVEN (US)
BURGESS STEVEN (US)
Application Number:
PCT/US2005/044978
Publication Date:
November 16, 2006
Filing Date:
December 12, 2005
Export Citation:
Assignee:
STATE OF OREGON ACTING BY & TH (US)
PEYTON DAVID H (US)
BURGESS STEVEN (US)
PEYTON DAVID H (US)
BURGESS STEVEN (US)
International Classes:
A61K31/55; A61K31/44; A61K31/47; A61K31/497; A61K31/54; A61P33/06; C07D215/00; C07D219/12; C07D221/00; C07D223/18; C07D243/08; C07D279/24; C07D401/00; C07D417/00
Domestic Patent References:
| WO2004099179A1 | 2004-11-18 |
Foreign References:
| EP0326331A2 | 1989-08-02 |
Other References:
CHEN J.M. ET AL.: "Structure-Based Design of Potent Inhibitors of Scytalone Dehydratase: Displacement of a Water Molecule from the Active Site", BIOCHEMISTRY, vol. 37, no. 51, 22 December 1998 (1998-12-22), pages 17735 - 17744, XP003003612
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