Title:
QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS
Document Type and Number:
WIPO Patent Application WO/2009/134973
Kind Code:
A8
Abstract:
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
Inventors:
VU CHI B (US)
DISCH JEREMY S (US)
SPRINGER STEPHANIE K (US)
BLUM CHARLES A (US)
PERNI ROBERT B (US)
DISCH JEREMY S (US)
SPRINGER STEPHANIE K (US)
BLUM CHARLES A (US)
PERNI ROBERT B (US)
Application Number:
PCT/US2009/042255
Publication Date:
December 16, 2010
Filing Date:
April 30, 2009
Export Citation:
Assignee:
SIRTRIS PHARMACEUTICALS INC (US)
VU CHI B (US)
DISCH JEREMY S (US)
SPRINGER STEPHANIE K (US)
BLUM CHARLES A (US)
PERNI ROBERT B (US)
VU CHI B (US)
DISCH JEREMY S (US)
SPRINGER STEPHANIE K (US)
BLUM CHARLES A (US)
PERNI ROBERT B (US)
International Classes:
A61K31/535
Attorney, Agent or Firm:
SUTTON, Jeffrey, A. et al. (Corporate Intellectual Property UW2220,709 Swedeland Road, P.O. Box 153, King Of Prussia PA, US)
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