QUINOLINONE AMIDE-CONTAINING COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF

Title:

QUINOLINONE AMIDE-CONTAINING COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/030459

Kind Code:

A1

Abstract:

The present invention provides a quinolinone amide-containing compound, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof. Specifically, the present invention provides a quinolinone amide compound having a structure shown in general formula I, and a racemate thereof, an R-isomer thereof, an S-isomer thereof, a pharmaceutically acceptable salt thereof, or a mixture thereof. The compound has excellent inhibitory activity against 3CL protease, and therefore can be used in treating, preventing, and alleviating diseases related to 3CL protease, especially in treating viral diseases related to 3CL protease, such as diseases caused by SARS-CoV-2, SARS-CoV, MERS-CoV, Norovirus, etc.

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Inventors:

ZHOU YU (CN)
LI JIA (CN)
ZHANG LEIKE (CN)
JIANG ZHIDONG (CN)
ZANG YI (CN)
ZHANG YUMIN (CN)
ZHENG MIAO (CN)
SU MINGBO (CN)
FENG BO (CN)
XIAO GENGFU (CN)
LIU HONG (CN)
JIANG HUALIANG (CN)

Application Number:

PCT/CN2022/116584

Publication Date:

March 09, 2023

Filing Date:

September 01, 2022

Export Citation:

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Assignee:

SHANGHAI INST MATERIA MEDICA CAS (CN)
WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCIENCE (CN)

International Classes:

C07D401/06; A61K31/495; A61P31/14

Foreign References:

CN1323209A	2001-11-21
JPS5929668A	1984-02-16
CN1214685A	1999-04-21

Other References:

DATABASE REGISTRY 25 April 2021 (2021-04-25), ANONYMOUS: "L25 ANSWER 1 OF 103: RN 2637531-59-8: CN 2(1H)-Quinolinone, 7-fluoro-4-[ [ 4-(phenylsulfonyl)-1-piperazinyl]carbonyl]", XP009544609, retrieved from STN Database accession no. RN 2637531-59-8

Attorney, Agent or Firm:

XU&PARTNERS, LLC. (CN)

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