Title:
QUINOLINONE COMPOUND AND ANTI-RNA VIRUS DRUG
Document Type and Number:
WIPO Patent Application WO/2018/181892
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a compound which has an anti-RNA virus activity and is useful as an anti-RNA virus drug, particularly an anti-influenza virus drug. The present invention provides a compound represented by formula (I) (wherein each symbol is as defined in the description) or a salt thereof.
Inventors:
MIZUTA SATOSHI (JP)
WATANABE KEN (JP)
NISHIDA NORIYUKI (JP)
HAMADA TUYOSHI (JP)
ISHIKAWA TAKESHI (JP)
TANAKA YOSHIMASA (JP)
OTAKI HIROKI (JP)
YASUDA JIRO (JP)
URATA SHUZO (JP)
WATANABE KEN (JP)
NISHIDA NORIYUKI (JP)
HAMADA TUYOSHI (JP)
ISHIKAWA TAKESHI (JP)
TANAKA YOSHIMASA (JP)
OTAKI HIROKI (JP)
YASUDA JIRO (JP)
URATA SHUZO (JP)
Application Number:
PCT/JP2018/013592
Publication Date:
October 04, 2018
Filing Date:
March 30, 2018
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
International Classes:
A61K31/47; C07D215/12; A61K31/4704; A61K31/4709; A61K31/662; A61P31/14; A61P31/16; C07D215/18; C07D215/227; C07D215/233; C07D215/54; C07D215/60; C07D401/06; C07D401/14; C07F9/60
Domestic Patent References:
| WO2012120398A1 | 2012-09-13 | |||
| WO2007008541A2 | 2007-01-18 |
Foreign References:
| JP2007001885A | 2007-01-11 | |||
| US20100210836A1 | 2010-08-19 |
Other References:
BOTTINI, ANGEL ET AL.: "Identification of Small Molecules that Interfere with H1N1 Influenza A Viral Replication", CHEMMEDCHEM, vol. 7, no. 12, December 2012 (2012-12-01), pages 2227 - 2235, XP055564201, ISSN: 1860-7179
THERESE, PATRISHA JOSEPH ET AL.: "Multiple e- Pharmacophore Modeling, 3D-QSAR, and High- Throughput Virtual Screening of Hepatitis C Virus NS5B Polymerase Inhibitors", JOURNAL OF CHEMICAL INFORMATION AND MODELING, vol. 54, no. 2, February 2014 (2014-02-01), pages 539 - 552, XP055564206, ISSN: 1549-9596
HADIDA, SABINE ET AL.: "Discovery of N-(2, 4-Di- tert-butyl-5-hydroxyphenyl)-4-oxo-l, 4- dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 23, 2014, pages 9776 - 9795, XP055294383, ISSN: 0022-2623
ANDREWS, D. MARK ET AL.: "Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold- Related Pain", ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 4, 2015, pages 419 - 424, XP055344958, ISSN: 1948-5875
DATABASE Registry [O] 26 May 2008 (2008-05-26), retrieved from stn Database accession no. RN 1022676-06-7
DATABASE Registry 4 March 2016 (2016-03-04), retrieved from stn Database accession no. RN 1879639-18-5
DATABASE Registry 27 May 2008 (2008-05-27), retrieved from stn Database accession no. RN 1022882-96-7
DATABASE Registry 17 October 2003 (2003-10-17), retrieved from stn Database accession no. RN 606116-18-1
DATABASE Registry 23 May 2008 (2008-05-23), retrieved from stn Database accession no. RN 1022099-77-9
THERESE, PATRISHA JOSEPH ET AL.: "Multiple e- Pharmacophore Modeling, 3D-QSAR, and High- Throughput Virtual Screening of Hepatitis C Virus NS5B Polymerase Inhibitors", JOURNAL OF CHEMICAL INFORMATION AND MODELING, vol. 54, no. 2, February 2014 (2014-02-01), pages 539 - 552, XP055564206, ISSN: 1549-9596
HADIDA, SABINE ET AL.: "Discovery of N-(2, 4-Di- tert-butyl-5-hydroxyphenyl)-4-oxo-l, 4- dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 23, 2014, pages 9776 - 9795, XP055294383, ISSN: 0022-2623
ANDREWS, D. MARK ET AL.: "Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold- Related Pain", ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 4, 2015, pages 419 - 424, XP055344958, ISSN: 1948-5875
DATABASE Registry [O] 26 May 2008 (2008-05-26), retrieved from stn Database accession no. RN 1022676-06-7
DATABASE Registry 4 March 2016 (2016-03-04), retrieved from stn Database accession no. RN 1879639-18-5
DATABASE Registry 27 May 2008 (2008-05-27), retrieved from stn Database accession no. RN 1022882-96-7
DATABASE Registry 17 October 2003 (2003-10-17), retrieved from stn Database accession no. RN 606116-18-1
DATABASE Registry 23 May 2008 (2008-05-23), retrieved from stn Database accession no. RN 1022099-77-9
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
Download PDF: