QUINOLINYL-SUBSTITUTED CARBOXYLIC ACID COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF

Title:

QUINOLINYL-SUBSTITUTED CARBOXYLIC ACID COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/072614

Kind Code:

A1

Abstract:

Provided in the present invention is a quinolinyl-substituted carboxylic acid compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and also disclosed are a preparation method and the use of the compound and a preparation comprising the quinolinyl-substituted carboxylic acid compound or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of the protein kinase AXL and/or VEGFR2 and can be used for treating diseases caused by aberrant activity of both kinases, such as tumours, etc.

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Inventors:

ZHANG ZHIQIANG (CN)
WANG XIJUAN (CN)
ZHANG XUEHUI (CN)
QIU JUNXIA (CN)
YANG JIEHE (CN)
ZHANG XIAOKAI (CN)
YAO PENG (CN)

Application Number:

PCT/CN2017/104518

Publication Date:

April 26, 2018

Filing Date:

September 29, 2017

Export Citation:

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Assignee:

BEIJING KONRUNS PHARMACEUTICAL CO LTD (CN)

International Classes:

C07D401/12; A61K31/47; A61K31/4709; A61P1/16; A61P3/10; A61P9/00; A61P17/06; A61P25/00; A61P27/02; A61P35/00; A61P37/02; C07D215/233

Domestic Patent References:

WO2005030140A2

2005-04-07

Foreign References:

CN102408411B	2014-10-22
CN1507434A	2004-06-23

Other References: