Title:
QUINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/1986/004058
Kind Code:
A1
Abstract:
Quinone derivatives represented by general formula (I), wherein R1 and R2 may be the same or different and each represents hydrogen, methyl or methoxy or, when taken together, R1 and R2 represent -CH=CH-CH=CH-, R3 represents hydrogen or methyl, R4 represents an optionally substituted aliphatic, aromatic or heterocyclic group, R5 represents methyl, methoxy, optionally substituted hydroxymethyl, an optionally amidated or esterified carboxyl group, Z represents formula (II) or formula (III), n represents an integer of 0 to 10, m represents an integer of 0 to 3, and k represents an integer of 0 to 5, provided that Z and k of the repeating units within the brackets may optionally vary when m represents 2 or 3 are novel, and show an effect of improving metabolism of polyvalent unsaturated fatty acids, particularly an effect of inhibiting production of fatty acid peroxides (i.e., antioxidant effect) or production of 5-lipoxygenase metabolites on mammals, thus being useful as antiasthmatic agent, antiallergic agent, brain circulation improving agent, etc.
Inventors:
TERAO SHINJI (JP)
MAKI YOSHITAKA (JP)
MAKI YOSHITAKA (JP)
Application Number:
PCT/JP1985/000003
Publication Date:
July 17, 1986
Filing Date:
January 08, 1985
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
International Classes:
C07C50/28; C07C45/29; C07C46/00; C07C46/02; C07C46/06; C07C47/277; C07C50/02; C07C50/06; C07C50/08; C07C50/30; C07C50/32; C07C66/00; C07C69/95; C07D333/22; C07D333/24; C07D521/00; (IPC1-7): C07C50/02; A61K31/12; A61K31/16; A61K31/19; A61K31/215; A61K31/38; C07C50/10; C07C59/84; C07C69/738; C07C103/22; C07C103/76; C07D333/16; C07D333/24
Other References:
Chemical and Pharmaceutical Bulletin, Vol. 26, No. 3 (1978), p. 774-783
Tetrahedron, Vol. 25, No. 7 (1969), p. 1407-1416
Bull. Chem. Soc. Jpn., Vol. 55, No. 8 p. 2415-2423
Tetrahedron, Vol. 25, No. 7 (1969), p. 1407-1416
Bull. Chem. Soc. Jpn., Vol. 55, No. 8 p. 2415-2423
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