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Title:
QUINONES FOR TREATMENT OF DISEASES
Document Type and Number:
WIPO Patent Application WO2000066528
Kind Code:
A3
Abstract:
Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.

Inventors:
BLOKHIN ANDREI V (US)
FRYDMAN BENJAMIN (US)
MARTON LAURENCE J (US)
NEDER KAREN M (US)
SUN JERRY SHUNNENG (US)
Application Number:
PCT/US2000/011538
Publication Date:
February 08, 2001
Filing Date:
April 27, 2000
Export Citation:
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Assignee:
SLIL BIOMEDICAL CORP (US)
BLOKHIN ANDREI V (US)
FRYDMAN BENJAMIN (US)
MARTON LAURENCE J (US)
NEDER KAREN M (US)
SUN JERRY SHUNNENG (US)
International Classes:
A61K31/122; A61K31/16; A61K31/165; A61K31/22; A61K31/222; A61K31/265; A61K31/275; A61K31/343; A61K31/353; A61K31/401; A61K31/409; A61K31/473; A61K31/496; A61K31/5355; A61K31/661; C07D221/08; A61K31/704; A61K38/00; A61K47/48; A61P35/00; C07C45/00; C07C45/46; C07C46/00; C07C50/32; C07C67/343; C07C69/24; C07C69/708; C07C69/96; C07C217/12; C07C219/34; C07C229/12; C07C229/22; C07C233/31; C07C237/22; C07C255/54; C07C301/00; C07C305/20; C07C323/22; C07D207/34; C07D209/44; C07D209/48; C07D219/10; C07D235/18; C07D235/20; C07D295/185; C07D307/79; C07D307/92; C07D311/92; C07D317/70; C07D487/22; C07D493/04; C07F9/09; C07F9/12; C07F9/655; C07H15/20; C07K5/027; C07K5/10; C07K5/103; C07K7/02; C07K7/06; (IPC1-7): C07C50/10; C07C50/32; A61P35/04; C07D219/10; C07H15/203; C07D235/12; C07C317/46; C07C219/34; C07C229/08; C07C237/12; C07C233/03; C07C233/05; C07F9/145; C07K7/06; C07K5/10
Domestic Patent References:
WO1997031936A21997-09-04
WO1997031611A21997-09-04
WO1997008162A11997-03-06
Foreign References:
US4273706A1981-06-16
EP0255679A21988-02-10
US5763625A1998-06-09
Other References:
TAKUWA, AKIO ET AL: "Structural influences on the isomerization of 4-benzyl- and 4-allyl-1,2-naphthoquinones to quinone methides and their stereochemistry", J. CHEM. SOC., PERKIN TRANS. 1 (1986), (9), 1627-31, XP002142390
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PERSHIN, G. N. ET AL: "Bonaphthon, a new antiviral chemotherapeutic agent", XP002142391, retrieved from STN Database accession no. 82:118979
NELSON, WENDEL L. ET AL: "3,4-Catechol derivative of propranolol, a minor dihydroxylated metabolite", J. MED. CHEM. (1984), 27(7), 857-61, XP002142392
BULLOCK, F. J. ET AL: "Antiprotozoal quinones. II. Synthesis of 4-amino-1,2- naphthoquinones and related compounds as potential antimalarials", J. MED. CHEM. (1970), 13(1), 97-103, XP002142393
DUNN, W. J., III ET AL: "Structure-activity analyzed by pattern recognition: the asymmetric case", J. MED. CHEM. (1980), 23(6), 595-9, XP002142394
TAKUWA, AKIO ET AL: "Addition of alcohol to 1,2-naphthoquinone promoted by metal ions. Facile synthesis of 4-alkoxy-1,2-naphthoquinones", BULL. CHEM. SOC. JPN. (1986), 59(9), 2959-61, XP002142395
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DOLAN, M. EILEEN ET AL: "Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents", XP002142396, retrieved from STN Database accession no. 129:156459
COTE, PHILIP N. ET AL: "Glucopyranosides derived from 2-hydroxy-1,4-naphthoquinones", CARBOHYD. RES., vol. 26, no. 1, 1973, pages 247 - 251, XP000925262
PLANCHON, SARAH M. ET AL: "Bcl-2 protects against.beta.-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells", ONCOL. REP., vol. 6, no. 3, 1999, pages 485 - 492, XP000957471
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