Title:
QUINOXALINYL-PIPERAZINAMIDE METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2017/040980
Kind Code:
A3
Abstract:
The disclosed subject matter provides methods using and kits comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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Inventors:
KIM DEOG JOONG (US)
LEE YOUNG BOK (US)
MAZHARI REZA (US)
EMRICH DANIEL EDWARD (US)
LEE YOUNG BOK (US)
MAZHARI REZA (US)
EMRICH DANIEL EDWARD (US)
Application Number:
PCT/US2016/050172
Publication Date:
May 11, 2017
Filing Date:
September 02, 2016
Export Citation:
Assignee:
REXAHN PHARMACEUTICALS INC (US)
International Classes:
A61K31/498; A61K9/14; A61P35/00
Foreign References:
| US20150004234A1 | 2015-01-01 | |||
| US20130053390A1 | 2013-02-28 | |||
| US20140341917A1 | 2014-11-20 |
Other References:
LEE YOUNG BOK ET AL: "Synthesis, anticancer activity and pharmacokinetic analysis of 1-[(substituted 2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, no. 3, 27 December 2011 (2011-12-27), pages 1303 - 1309, XP028886960, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2011.12.026
LEE Y B ET AL: "Synthesis and anticancer activity of new 1-[(5 or 6-substituted 2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 18, no. 22, 15 November 2010 (2010-11-15), pages 7966 - 7974, XP027452459, ISSN: 0968-0896, [retrieved on 20100919], DOI: 10.1016/J.BMC.2010.09.028
S GAIL ECKHARDT ET AL: "A Phase 1 Study of RX-5902 (Supinoxin) an Oral Agent Targeting Phosphorylated p68 to Treat Subjects with Advanced Solid Tumors", PRESENTED AT THE 2015 AMERICAN SOCIETY OF CLINICAL ONCOLOGY (ASCO) ANNUAL MEETING, CHICAGO, ILLINOIS, MAY 29 - JUNE 2, 2015, 29 June 2015 (2015-06-29), XP055310474, Retrieved from the Internet [retrieved on 20161013]
GINA CHUN KOST ET AL: "A Novel Anti-Cancer Agent, 1-(3,5-Dimethoxyphenyl)-4-[(6-Fluoro-2-Methoxyquinoxalin-3-yl)Aminocarbonyl] Piperazine (RX-5902), Interferes With [beta]-Catenin Function Through Y593 Phospho-p68 RNA Helicase", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 116, no. 8, 10 June 2015 (2015-06-10), US, pages 1595 - 1601, XP055310461, ISSN: 0730-2312, DOI: 10.1002/jcb.25113
W LARRY GLUCK ET AL: "Single Agent Supinoxin Targeting Phosphorylated p-68 Preliminary Phase 1 Data", (PRESENTED AT THE 2015 THE EUROPEAN CANCER CONGRESS (ECC 2015) ANNUAL MEETING, VIENNA, AUSTRIA, SEP 25 - 29, 2015, 25 September 2015 (2015-09-25), XP055310486, Retrieved from the Internet [retrieved on 20161013]
LEE Y B ET AL: "Synthesis and anticancer activity of new 1-[(5 or 6-substituted 2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 18, no. 22, 15 November 2010 (2010-11-15), pages 7966 - 7974, XP027452459, ISSN: 0968-0896, [retrieved on 20100919], DOI: 10.1016/J.BMC.2010.09.028
S GAIL ECKHARDT ET AL: "A Phase 1 Study of RX-5902 (Supinoxin) an Oral Agent Targeting Phosphorylated p68 to Treat Subjects with Advanced Solid Tumors", PRESENTED AT THE 2015 AMERICAN SOCIETY OF CLINICAL ONCOLOGY (ASCO) ANNUAL MEETING, CHICAGO, ILLINOIS, MAY 29 - JUNE 2, 2015, 29 June 2015 (2015-06-29), XP055310474, Retrieved from the Internet
GINA CHUN KOST ET AL: "A Novel Anti-Cancer Agent, 1-(3,5-Dimethoxyphenyl)-4-[(6-Fluoro-2-Methoxyquinoxalin-3-yl)Aminocarbonyl] Piperazine (RX-5902), Interferes With [beta]-Catenin Function Through Y593 Phospho-p68 RNA Helicase", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 116, no. 8, 10 June 2015 (2015-06-10), US, pages 1595 - 1601, XP055310461, ISSN: 0730-2312, DOI: 10.1002/jcb.25113
W LARRY GLUCK ET AL: "Single Agent Supinoxin Targeting Phosphorylated p-68 Preliminary Phase 1 Data", (PRESENTED AT THE 2015 THE EUROPEAN CANCER CONGRESS (ECC 2015) ANNUAL MEETING, VIENNA, AUSTRIA, SEP 25 - 29, 2015, 25 September 2015 (2015-09-25), XP055310486, Retrieved from the Internet
Attorney, Agent or Firm:
KWOK, Annette K. (US)
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