(R)-5-BROMO-N-(1-ETHYL-4-METHYLHEXAHYDRO-1H-1,4-DIAZEPIN-6-YL)-2-METHOXY-6-METHYLAMINO-3-PYRIDINE-CARBOXAMIDE, PROCESS FOR PRODUCING THE SAME AND MEDICINAL COMPOSITION CONTAINING THE SAME

Title:

(R)-5-BROMO-N-(1-ETHYL-4-METHYLHEXAHYDRO-1H-1,4-DIAZEPIN-6-YL)-2-METHOXY-6-METHYLAMINO-3-PYRIDINE-CARBOXAMIDE, PROCESS FOR PRODUCING THE SAME AND MEDICINAL COMPOSITION CONTAINING THE SAME

Document Type and Number:

WIPO Patent Application WO/1997/005129

Kind Code:

A1

Abstract:

The compound represented by formula (I) and physiologically acceptable acid-addition salts thereof. The compounds have an excellent antiemetic effect based on potent antagonism against serotonin S3 and dopamine D2 receptors and, therefore, are usable as an antiemetic agent in the treatment or prevention of various diseases and many digestive symptoms accompanying the administration of drugs, etc.

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JPS62207271	CONDENSED RING COMPOUND SUBSTITUTED WITH 2-PYRIDYLMETHYLTHIO GROUP OR 2-PYRIDYLMETHYLSULFINYL GROUP
WO/1997/018207	NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS
JPH02240064	CONDENSED 3-OXOPROPANENITRILE DERIVATIVE AND PRODUCTION THEREOF

Inventors:

KATO SHIRO (JP)
HIROKAWA YOSHIMI (JP)
MORIE TOSHIYA (JP)
HARADA HIROSHI (JP)
YOSHIDA NAOYUKI (JP)

Application Number:

PCT/JP1996/002053

Publication Date:

February 13, 1997

Filing Date:

July 23, 1996

Export Citation:

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Assignee:

DAINIPPON PHARMACEUTICAL CO (JP)
KATO SHIRO (JP)
HIROKAWA YOSHIMI (JP)
MORIE TOSHIYA (JP)
HARADA HIROSHI (JP)
YOSHIDA NAOYUKI (JP)

International Classes:

A61K31/44; A61K31/5513; A61P1/08; C07D243/08; C07D401/12; (IPC1-7): C07D401/12; C07D243/08; A61K31/55

Foreign References:

JPH04210970A	1992-08-03
JPH0592959A	1993-04-16
JPH03223265A	1991-10-02

Other References: