Title:
R-HYDROXYNEFAZODONE
Document Type and Number:
WIPO Patent Application WO2000061128
Kind Code:
A3
Abstract:
The R-isomer of the hydroxy metabolite of nefazodone, R-hydroxynefazodone, is an effective treatment for depression which does not give rise to the adverse effects associated with nefazodone. R-hydroxynefazodone is also useful in the treatment of migraine headaches, panic disorders, post traumatic stress disorder and sleep disorders.
Inventors:
BARBERICH TIMOTHY J (US)
RUBIN PAUL D (US)
YELLE WILLIAM E (US)
RUBIN PAUL D (US)
YELLE WILLIAM E (US)
Application Number:
PCT/US2000/009373
Publication Date:
August 16, 2001
Filing Date:
April 07, 2000
Export Citation:
Assignee:
SEPRACOR INC (US)
BARBERICH TIMOTHY J (US)
RUBIN PAUL D (US)
YELLE WILLIAM E (US)
BARBERICH TIMOTHY J (US)
RUBIN PAUL D (US)
YELLE WILLIAM E (US)
International Classes:
A61K31/496; A61P25/00; A61P25/06; A61P25/20; A61P25/22; A61P25/24; A61P29/00; C07D249/12; C07D249/08; (IPC1-7): A61K31/496; A61P25/00; A61P3/04; A61P25/24; A61P25/20; A61P25/22; A61P25/06; A61P25/18; C07D249/12
Foreign References:
| US4613600A | 1986-09-23 | |||
| US5788986A | 1998-08-04 | |||
| US5256664A | 1993-10-26 | |||
| US4338317A | 1982-07-06 |
Other References:
CYR M ET AL: "NEFAZODONE: ITS PLACE AMONG ANTIDEPRESSANTS", ANNALS OF PHARMACOTHERAPY,XX,XX, vol. 30, no. 9, 1 September 1996 (1996-09-01), pages 1006 - 1012, XP000613004, ISSN: 1060-0280
MALIK, KEMAL: "Nefazodone: structure, mode of action and pharmacokinetics", J. PSYCHOPHARMACOL., vol. 10 (Suppl. 1), 1996, pages 1 - 4, XP000861812
NACCA ANGELO; GUISO GIOVANNA; FRACASSO CLAUDIA; CERVO LUIGI; CACCIA SILVIO: "Brain-to-blood partition and in vivo inhibition of 5-hydroxytryptamine reuptake and quipazine-mediated behaviour of nefazodone and its main active metabolites in rodents.", BRITISH JOURNAL OF PHARMACOLOGY, vol. 125, no. 7, December 1998 (1998-12-01), pages 1617 - 1623, XP000861819
MONTGOMERY S A: "EFFICACY OF NEFAZODONE IN THE TREATMENT OF DEPRESSION", JOURNAL OF PSYCHOPHARMACOLOGY,GB,OXFORD UNIVERSITY PRESS, vol. 10, no. SUPPL. 01, 1996, pages 5 - 10, XP000613043, ISSN: 0269-8811
GREENE D S ET AL: "Clinical pharmacokinetics of nefazodone.", CLINICAL PHARMACOKINETICS, (1997 OCT) 33 (4) 260-75. REF: 51, XP000911986
SCHMIDER J ET AL: "Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation.", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, (1996 APR) 41 (4) 339-43., XP000861967
MALIK, KEMAL: "Nefazodone: structure, mode of action and pharmacokinetics", J. PSYCHOPHARMACOL., vol. 10 (Suppl. 1), 1996, pages 1 - 4, XP000861812
NACCA ANGELO; GUISO GIOVANNA; FRACASSO CLAUDIA; CERVO LUIGI; CACCIA SILVIO: "Brain-to-blood partition and in vivo inhibition of 5-hydroxytryptamine reuptake and quipazine-mediated behaviour of nefazodone and its main active metabolites in rodents.", BRITISH JOURNAL OF PHARMACOLOGY, vol. 125, no. 7, December 1998 (1998-12-01), pages 1617 - 1623, XP000861819
MONTGOMERY S A: "EFFICACY OF NEFAZODONE IN THE TREATMENT OF DEPRESSION", JOURNAL OF PSYCHOPHARMACOLOGY,GB,OXFORD UNIVERSITY PRESS, vol. 10, no. SUPPL. 01, 1996, pages 5 - 10, XP000613043, ISSN: 0269-8811
GREENE D S ET AL: "Clinical pharmacokinetics of nefazodone.", CLINICAL PHARMACOKINETICS, (1997 OCT) 33 (4) 260-75. REF: 51, XP000911986
SCHMIDER J ET AL: "Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation.", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, (1996 APR) 41 (4) 339-43., XP000861967
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