Title:
(R)-PRAZIQUANTEL PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO/2015/055127
Kind Code:
A1
Abstract:
The present invention relates to an (R)-praziquantel preparation method, comprising steps of using (R,S)-tetrahydroisoquinoline-1-formate or salts thereof, or 1-(S)-tetrahydroisoquinoline-1-formate or salts thereof as a raw material to prepare 1-(R)-tetrahydroisoquinoline-1-formate salts, and steps of preparing (R)-praziquantel from said 1-(R)-tetrahydroisoquinoline-1-formate salts. The preparation method for 1-(R)-tetrahydroisoquinoline-1-formate or salts thereof is as follows: perform an oxidation reaction between the raw material described above and oxygen in the presence of recombinant D-amino acid oxidase and catalase, then perform a reduction reaction on the resulting product under the effect of a borane-amine complex, thus successively converting 1-(S)-tetrahydroisoquinoline-1-formate or salts thereof into the 1-(R)-tetrahydroisoquinoline-1-formate or salts thereof isomer. The present method not only produces an (R)-praziquantel product with a high optical purity, but is also low-cost and environmentally friendly in terms of production.
Inventors:
QIAN MINGXIN (CN)
Application Number:
PCT/CN2014/088713
Publication Date:
April 23, 2015
Filing Date:
October 16, 2014
Export Citation:
Assignee:
TONGLI BIOMEDICAL CO LTD (CN)
International Classes:
C07D217/16; C07D471/04; C12P13/04; C12P17/18; C12P41/00
Foreign References:
| CN103333942A | 2013-10-02 | |||
| CN103333931A | 2013-10-02 | |||
| CN101194020A | 2008-06-04 | |||
| CN1922328A | 2007-02-28 |
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT & TRADEMARK AGENCY LTD. (CN)
苏州创元专利商标事务所有限公司 (CN)
苏州创元专利商标事务所有限公司 (CN)
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