Title:
REGULATION OF INTERACTION BETWEEN RAPL AND Rap1
Document Type and Number:
WIPO Patent Application WO2004040302
Kind Code:
A8
Abstract:
It is considered that the disruption of the function of Rap1 as an integrin adhesion regulatory molecule would closely relate to the pathological conditions of immune diseases such as inflammation, allergy, autoimmune disease, cancer immunity and transplantation immunity. Thus, it is expected that the clarification of the integrin adhesion regulatory mechanism by Rap1 contributes to the understanding of the pathological conditions of these immune diseases and the development of therapies therefor. p30 is identified as a molecule relating to the integrin adhesion regulation by Rap1. It is found out that p30 binds to Rap1 and thus controls its function. Use of this finding makes it possible to develop an inhibitor of the binding of p30 to Rap1, develop remedies for inflammation, allergy, autoimmune disease, cancer immunity, transplantation immunity, etc. and, in its turn, clarify the regulatory mechanism.
Inventors:
KINASHI TATSUO (JP)
SHIKAMA HIROSHI (JP)
SHIKAMA HIROSHI (JP)
Application Number:
PCT/JP2003/013937
Publication Date:
March 24, 2005
Filing Date:
October 30, 2003
Export Citation:
Assignee:
ISHIHARA SANGYO KAISHA (JP)
KINASHI TATSUO (JP)
SHIKAMA HIROSHI (JP)
KINASHI TATSUO (JP)
SHIKAMA HIROSHI (JP)
International Classes:
A61K31/44; A61P29/00; A61P35/00; A61P37/02; A61P37/06; G01N33/68; (IPC1-7): G01N33/50; A01K67/027; A61K31/44; A61K38/17; A61K45/00; A61K48/00; A61P29/00; A61P35/00; A61P37/02; A61P37/06; C07K16/18; C12N15/00; G01N33/15; G01N33/566
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