Title:
RGMa BINDING PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/175236
Kind Code:
A1
Abstract:
The present invention addresses the problem of obtaining an anti-repulsive guidance molecule a (RGMa) antibody which has a high binding activity and few side effects and can be used as a medicine for preventing, treating, or preventing the relapse of neurological or immunological diseases. Said problem is solved by providing an isolated RGMa binding protein which does not inhibit binding between RGMa and neogenin, but neutralizes the neuritis growth inhibiting activity of RGMa, and preferably by providing an anti-RGMa antibody which has a complementarity determining region having an amino acid sequence of SEQ ID NOS: 30-35 or SEQ ID NOS: 36-40 in the sequence listing, and SFG.
Inventors:
HASHIMOTO MOTONORI (JP)
YAMASHITA TOSHIHIDE (JP)
YAMASHITA TOSHIHIDE (JP)
Application Number:
PCT/JP2016/063166
Publication Date:
November 03, 2016
Filing Date:
April 27, 2016
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
UNIV OSAKA (JP)
NAT UNIV CORP CHIBA UNIV (JP)
UNIV OSAKA (JP)
NAT UNIV CORP CHIBA UNIV (JP)
International Classes:
A61K39/395; C07K16/28; A61P25/00; A61P37/02; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/08
Domestic Patent References:
| WO2011071059A1 | 2011-06-16 | |||
| WO2005087268A1 | 2005-09-22 | |||
| WO2008038599A1 | 2008-04-03 |
Foreign References:
| JP2010537655A | 2010-12-09 | |||
| JP2011512806A | 2011-04-28 | |||
| JP2009510002A | 2009-03-12 | |||
| JP2015508061A | 2015-03-16 |
Other References:
HATA K. ET AL.: "RGMa inhibition promotes axonal growth and recovery after spinal cord injury", THE JOURNAL OF CELL BIOLOGY, vol. 173, no. 1, 2006, pages 47 - 58, XP002529131
MATSUURA I. ET AL.: "BMP inhibits neurite growth by a mechanism dependent on LIM-kinase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 360, 2007, pages 868 - 873, XP025990012
ARA J. ET AL.: "Bone Morphogenetic Proteins 4, 6, and 7 Are Up-Regulated in Mouse Spinal Cord during Experimental Autoimmune Encephalomyelitis", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 86, 2008, pages 125 - 135, XP055079871
See also references of EP 3290441A4
MATSUURA I. ET AL.: "BMP inhibits neurite growth by a mechanism dependent on LIM-kinase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 360, 2007, pages 868 - 873, XP025990012
ARA J. ET AL.: "Bone Morphogenetic Proteins 4, 6, and 7 Are Up-Regulated in Mouse Spinal Cord during Experimental Autoimmune Encephalomyelitis", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 86, 2008, pages 125 - 135, XP055079871
See also references of EP 3290441A4
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
Yoshiyuki Kawaguchi (JP)
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