Title:
RADIATION EXPOSURE TREATMENT AGENT AND RADIATION EXPOSURE TREATMENT METHOD
Document Type and Number:
WIPO Patent Application WO/2014/077358
Kind Code:
A1
Abstract:
Provided is a highly effective radiation exposure treatment agent. This radiation exposure treatment agent contains a thrombopoietin receptor agonist for removing antibodies, and regenerates organs damaged by radiation exposure. Romiplostim is used as the thrombopoietin receptor agonist. The romiplostim is administered at an amount, at each administration, 5-50 times greater than that for treatment of chronic immune thrombocytopenic purpura. Specifically, romiplostim is administered after exposure at an amount of 10-100 μg/kg per administration, once a day for three or more days.
Inventors:
KASHIWAKURA IKUO (JP)
ITO KOICHI (JP)
NAKANO MANABU (JP)
MONZEN SATORU (JP)
CHIBA MITSURU (JP)
YOSHINO HIRONORI (JP)
HIROUCHI TOKUHISA (JP)
ITO KOICHI (JP)
NAKANO MANABU (JP)
MONZEN SATORU (JP)
CHIBA MITSURU (JP)
YOSHINO HIRONORI (JP)
HIROUCHI TOKUHISA (JP)
Application Number:
PCT/JP2013/080889
Publication Date:
May 22, 2014
Filing Date:
November 15, 2013
Export Citation:
Assignee:
UNIV HIROSAKI (JP)
INST ENVIRONMENTAL SCIENCES (JP)
INST ENVIRONMENTAL SCIENCES (JP)
International Classes:
A61K45/00; A61K31/4152; A61K38/00; A61P43/00
Domestic Patent References:
| WO2008070583A2 | 2008-06-12 | |||
| WO2007094781A1 | 2007-08-23 |
Other References:
IKOU KASHIWAKURA ET AL: "KOKUNAI SHONIN IYAKUHIN O KUMIAWASETA KYUSEI HOSHASEN SHOGAI CHIRYO PROTOCOL NO TANSAKU", PROCEEDING OF THE ANNUAL MEETING OF THE JAPAN RADIATION RESEARCH SOCIETY, vol. 55, 4 December 2012 (2012-12-04), pages 92
DUIC J.P. ET AL: "ELTROMBOPAG FOR RADIATION-INDUCED THROMBOCYTOPENIA IN A GLIOBLASTOMA PATIENT", JOURNAL OF NEURO-ONCOLOG, vol. 106, no. 2, January 2012 (2012-01-01), pages 427 - 429
SATYAMITRA M. ET AL: "A TPO RECEPTOR AGONIST ALXN4100TPO MITIGATES RADIATION-INDUCED LETHALITY AND STIMULATES HEMATOPOIESIS IN CD2F1 MICE", RADIATION RESEARCH, vol. 175, no. 6, 2011, pages 746 - 758
ERICKSON MILLER C.L. ET AL: "PRECLINICAL ACTIVITY OF ELTROMBOPAG(SB497115) AN ORAL NONPEPTIDE THRONBOPOIETIN RECEPTOR AGONIST", STEM CELLS, vol. 27, no. 2, 2009, pages 424 - 430
SASAKI H. ET AL: "HST-1/FGF-4 PLAYS A CRITICAL ROLE IN CRYPT CELL SURVIVAL AND FACILITATES EPITHELIAL CELL RESTITUTION AND PROLIFERATION", ONCOGENE, vol. 23, no. 20, 2004, pages 3681 - 3688
TAKAHAMA Y. ET AL: "ADENOVIRUS-MEDISTED TRANSFER OF HST-1/FGF-4 GENE PROTECTS MICE FROM LETHAL IRRADIATION", ONCOGENE, vol. 18, no. 43, 1999, pages 5943 - 5947
MEYER O. ET AL: "SAFETY AND EFFICACY OF ROMIPLOSTIM THROMBOCYTOPENIC PURPURA", CLINICAL MEDECINE INSIGHTS:THERSPEUTICS, vol. 4, April 2012 (2012-04-01), pages 75 - 83
DUIC J.P. ET AL: "ELTROMBOPAG FOR RADIATION-INDUCED THROMBOCYTOPENIA IN A GLIOBLASTOMA PATIENT", JOURNAL OF NEURO-ONCOLOG, vol. 106, no. 2, January 2012 (2012-01-01), pages 427 - 429
SATYAMITRA M. ET AL: "A TPO RECEPTOR AGONIST ALXN4100TPO MITIGATES RADIATION-INDUCED LETHALITY AND STIMULATES HEMATOPOIESIS IN CD2F1 MICE", RADIATION RESEARCH, vol. 175, no. 6, 2011, pages 746 - 758
ERICKSON MILLER C.L. ET AL: "PRECLINICAL ACTIVITY OF ELTROMBOPAG(SB497115) AN ORAL NONPEPTIDE THRONBOPOIETIN RECEPTOR AGONIST", STEM CELLS, vol. 27, no. 2, 2009, pages 424 - 430
SASAKI H. ET AL: "HST-1/FGF-4 PLAYS A CRITICAL ROLE IN CRYPT CELL SURVIVAL AND FACILITATES EPITHELIAL CELL RESTITUTION AND PROLIFERATION", ONCOGENE, vol. 23, no. 20, 2004, pages 3681 - 3688
TAKAHAMA Y. ET AL: "ADENOVIRUS-MEDISTED TRANSFER OF HST-1/FGF-4 GENE PROTECTS MICE FROM LETHAL IRRADIATION", ONCOGENE, vol. 18, no. 43, 1999, pages 5943 - 5947
MEYER O. ET AL: "SAFETY AND EFFICACY OF ROMIPLOSTIM THROMBOCYTOPENIC PURPURA", CLINICAL MEDECINE INSIGHTS:THERSPEUTICS, vol. 4, April 2012 (2012-04-01), pages 75 - 83
Attorney, Agent or Firm:
HORI, Shiroyuki et al. (JP)
Ditch Shiroyuki (JP)
Ditch Shiroyuki (JP)
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