Title:
RADIATION SENSITIVE LIPOSOMES
Document Type and Number:
WIPO Patent Application WO2001039744
Kind Code:
A3
Abstract:
The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
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Inventors:
O'BRIEN DAVID F
MCGOVERN KATHY A
BONDURANT BRUCE
SUTHERLAND ROBERT M
MCGOVERN KATHY A
BONDURANT BRUCE
SUTHERLAND ROBERT M
Application Number:
PCT/US2000/032902
Publication Date:
January 24, 2002
Filing Date:
November 30, 2000
Export Citation:
Assignee:
UNIV ARIZONA (US)
International Classes:
A61K9/00; A61K9/127; A61K45/00; A61K47/34; A61K47/42; A61K47/44; A61K51/00; A61N5/10; (IPC1-7): A61K9/127
Other References:
LAMPARSKI H ET AL: "Photoinduced destabilization of liposomes.", BIOCHEMISTRY, (1992 JAN 28) 31 (3) 685-94., XP001002606
BENNETT D E ET AL: "Photoactivated enhancement of liposome fusion.", BIOCHEMISTRY, (1995 MAR 7) 34 (9) 3102-13., XP001002607
MILLER C R ET AL: "Effect of liposomal composition on photoactivated liposome fusion.", BIOCHEMISTRY, (1996 SEP 10) 35 (36) 11782-90., XP001002608
O'BRIEN ET AL: "Photoinduced reorganization of bilayer membranes", BIOORGANIC PHOTOCHEMISTRY, vol. 2, 1993, pages 111 - 167, XP001002759
WOODLE MC; LASIC DP: "Sterically stabilized liposomes", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1113, no. 2, 1992, pages 171 - 199, XP001002651
SILVANDERM; JOHNSSON M; EDWARDS K: "Effects of PEG-lipids on permeability of phosphatidylcholine/cholesterol liposomes in buffer and in human serum", CHEMISTRY AND PHYSICS IF LIPIDS, vol. 97, no. 1, 1998, pages 15 - 26, XP001002658
BONDURANT B ET AL: "Photoinitiated destabilization of sterically stabilized liposomes.", BIOCHIMICA ET BIOPHYSICA ACTA, (2001 MAR 9) 1511 (1) 113-22., vol. 1511, 2001, pages 113 - 122, XP001002738
BENNETT D E ET AL: "Photoactivated enhancement of liposome fusion.", BIOCHEMISTRY, (1995 MAR 7) 34 (9) 3102-13., XP001002607
MILLER C R ET AL: "Effect of liposomal composition on photoactivated liposome fusion.", BIOCHEMISTRY, (1996 SEP 10) 35 (36) 11782-90., XP001002608
O'BRIEN ET AL: "Photoinduced reorganization of bilayer membranes", BIOORGANIC PHOTOCHEMISTRY, vol. 2, 1993, pages 111 - 167, XP001002759
WOODLE MC; LASIC DP: "Sterically stabilized liposomes", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1113, no. 2, 1992, pages 171 - 199, XP001002651
SILVANDERM; JOHNSSON M; EDWARDS K: "Effects of PEG-lipids on permeability of phosphatidylcholine/cholesterol liposomes in buffer and in human serum", CHEMISTRY AND PHYSICS IF LIPIDS, vol. 97, no. 1, 1998, pages 15 - 26, XP001002658
BONDURANT B ET AL: "Photoinitiated destabilization of sterically stabilized liposomes.", BIOCHIMICA ET BIOPHYSICA ACTA, (2001 MAR 9) 1511 (1) 113-22., vol. 1511, 2001, pages 113 - 122, XP001002738
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