Title:
RADIATION SENSITIVITY ENHANCING COMPOSITION CONTAINING ARIPIPRAZOLE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2019/212185
Kind Code:
A1
Abstract:
The present invention pertains to a radiation sensitivity enhancing composition containing aripiprazole as an active ingredient, and more particularly, to a radiation sensitivity enhancing composition that can treat cancer with aripiprazole acting as a radiation sensitizer when used in combination with radiation therapy. Administrating an effective amount of aripiprazole according to the present invention in combination with radiation therapy has excellent radiation sensitivity enhancing effects, such as reducing cancer cell viability and inducing cancer cell death, and the present invention can therefore be usefully used as a radiation sensitivity enhancer.
Inventors:
LIM YOUNG BIN (KR)
PARK MYUNG JIN (KR)
LEE HYOUN JI (KR)
PARK MYUNG JIN (KR)
LEE HYOUN JI (KR)
Application Number:
PCT/KR2019/004900
Publication Date:
November 07, 2019
Filing Date:
April 23, 2019
Export Citation:
Assignee:
KOREA INST RADIOLOGICAL & MEDICAL SCIENCES (KR)
International Classes:
A61K31/546; A23L33/10; A61K31/4515; A61K31/496; A61K31/5415; A61P35/00; A61P43/00
Foreign References:
| KR20170026115A | 2017-03-08 | |||
| US20070099905A1 | 2007-05-03 | |||
| KR20090065514A | 2009-06-22 |
Other References:
LI, H. ET AL.: "Thioridazine sensitizes esophageal carcinoma cell lines to radiotherapy-induced apoptosis in vitro and in vivo", MEDICAL SCIENCE MONITOR., vol. 22, 2016, pages 2624 - 2634, XP055648597
SUZUKI, S. ET AL.: "Aripiprazole, an antipsychotic and partial dopamine agonist, inhibits cancer stem cells and reverses chemoresistance", ANTICANCER RESEARCH, vol. 36, no. 10, 2016, pages 5153 - 5161, XP055405053
See also references of EP 3789029A4
SUZUKI, S. ET AL.: "Aripiprazole, an antipsychotic and partial dopamine agonist, inhibits cancer stem cells and reverses chemoresistance", ANTICANCER RESEARCH, vol. 36, no. 10, 2016, pages 5153 - 5161, XP055405053
See also references of EP 3789029A4
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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