Title:
RADICICOL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1998/018780
Kind Code:
A1
Abstract:
Radicicol derivatives having an antityrosine kinase activity and represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R?1� and R?2� are the same or different and each represents hydrogen, alkanoyl, alkenoyl, tert-butyldiphenylsilyl, or tert-butyldimethylsilyl; R?3� represents Y- R?5� {where Y represents optionally substituted alkylene, R?5� represents CONR?6�R?7� (where R?6� represents hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted higher alkyl, etc. and R?7� represents hydroxy, substituted lower alkyl, etc.), CO�2?R?12� (where R?12� represents substituted lower alkyl, optionally substituted higher alkyl, etc.), etc.}; X represents halogeno or is bonded to R?4� to represent a single bond; and R?4� is bonded to X to represent a single bond or represents hydrogen alkanoyl, etc.
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Inventors:
INO YOJI (JP)
AMISHIRO NOBUYOSHI (JP)
MIYATA MAYUMI (JP)
MURAKATA CHIKARA (JP)
OGAWA HARUMI (JP)
AKIYAMA TADAKAZU (JP)
AKINAGA SHIRO (JP)
SOGA SHIROH (JP)
SHIOTSU YUKIMASA (JP)
AMISHIRO NOBUYOSHI (JP)
MIYATA MAYUMI (JP)
MURAKATA CHIKARA (JP)
OGAWA HARUMI (JP)
AKIYAMA TADAKAZU (JP)
AKINAGA SHIRO (JP)
SOGA SHIROH (JP)
SHIOTSU YUKIMASA (JP)
Application Number:
PCT/JP1997/003874
Publication Date:
May 07, 1998
Filing Date:
October 24, 1997
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
INO YOJI (JP)
AMISHIRO NOBUYOSHI (JP)
MIYATA MAYUMI (JP)
MURAKATA CHIKARA (JP)
OGAWA HARUMI (JP)
AKIYAMA TADAKAZU (JP)
AKINAGA SHIRO (JP)
SOGA SHIROH (JP)
SHIOTSU YUKIMASA (JP)
INO YOJI (JP)
AMISHIRO NOBUYOSHI (JP)
MIYATA MAYUMI (JP)
MURAKATA CHIKARA (JP)
OGAWA HARUMI (JP)
AKIYAMA TADAKAZU (JP)
AKINAGA SHIRO (JP)
SOGA SHIROH (JP)
SHIOTSU YUKIMASA (JP)
International Classes:
C07D313/00; C07D493/04; (IPC1-7): C07D313/00; C07D493/04; C07F7/10; A61K31/365; A61K31/40; A61K31/44; A61K31/445; A61K31/505; A61K31/535; A61K31/54; A61K31/55; A61K31/695
Domestic Patent References:
| WO1996033989A1 | 1996-10-31 |
Foreign References:
| JPH06279279A | 1994-10-04 | |||
| JPH0840893A | 1996-02-13 | |||
| JPH09202781A | 1997-08-05 |
Other References:
See also references of EP 0889042A4
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