Title:
RADIOACTIVE ANTITUMOR AGENT
Document Type and Number:
WIPO Patent Application WO/2019/087957
Kind Code:
A1
Abstract:
This radioactive antitumor agent comprises a radioactive dithiosemicarbazone-copper complex as an active ingredient, and is characterized by being used in such a way that the radioactive dithiosemicarbazone-copper complex is administered multiple times to an organism requiring tumor treatment, at a radioactive dose that does not result in dose-limiting toxicity, as determined on the basis of hematological parameters. The multiple administration preferably consists of intermittent administration at time intervals allowing the hematological parameters to return to a normal range.
Inventors:
YOSHII YUKIE (JP)
MATSUMOTO HIROKI (JP)
MATSUMOTO HIROKI (JP)
Application Number:
PCT/JP2018/039865
Publication Date:
May 09, 2019
Filing Date:
October 26, 2018
Export Citation:
Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECH (JP)
NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECH (JP)
International Classes:
A61K51/00; A61P35/00
Foreign References:
| JP2014129316A | 2014-07-10 |
Other References:
YOSHII, YUKIE ET AL.: "Internal radiotherapy with copper-64-diacetyl-bis (N4-methylthiosemicarbazone) reduces CD 133+ highly tumorigenic cells and metastatic ability of mouse colon carcinoma", NUCLEAR MEDICINE AND BIOLOGY, vol. 38, no. 2, 2011, pages 151 - 157, XP028359715, DOI: doi:10.1016/j.nucmedbio.2010.08.009
LEWIS, JASON S. ET AL.: "Copper-64-diacetyl-bis(N''- methylthiosemicarbazone): An agent for radiotherapy", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 1206 - 1211, XP008110962, DOI: doi:10.1073/pnas.98.3.1206
YOSHII, YUKIE ET AL.: "Multiple administrations of 64CU-ATSM as a novel therapeutic option for glioblastoma: a translational study using mice with xenografts", TRANSLATIONAL ONCOLOGY, vol. 11, no. 1, February 2018 (2018-02-01), pages 24 - 30, XP055614323
LEWIS, JASON S. ET AL.: "Copper-64-diacetyl-bis(N''- methylthiosemicarbazone): An agent for radiotherapy", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 1206 - 1211, XP008110962, DOI: doi:10.1073/pnas.98.3.1206
YOSHII, YUKIE ET AL.: "Multiple administrations of 64CU-ATSM as a novel therapeutic option for glioblastoma: a translational study using mice with xenografts", TRANSLATIONAL ONCOLOGY, vol. 11, no. 1, February 2018 (2018-02-01), pages 24 - 30, XP055614323
Attorney, Agent or Firm:
IDE Masatake (JP)
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