Title:
RADIOACTIVE COMPLEX OF DEGLYCOSYLATED ANTIBODY AND RADIOACTIVE PHARMACEUTICAL PRODUCT
Document Type and Number:
WIPO Patent Application WO/2023/033022
Kind Code:
A1
Abstract:
The present invention provides "a complex of a chelating agent in which a radionuclide has been chelated and an antibody which has been deglycosylated, wherein the chelating agent site-specifically modifies an Fc region of the antibody via a linker." In the complex, a reduction in efficacy and the risk of side effects are ameliorated.
Inventors:
KISHIMOTO SATOSHI (JP)
TAKEDA TAKUYA (JP)
NARITA YUDAI (JP)
KAWATANI MINORU (JP)
IZAWA AKIHIRO (JP)
TARUMIZU YUTA (JP)
TAKEDA TAKUYA (JP)
NARITA YUDAI (JP)
KAWATANI MINORU (JP)
IZAWA AKIHIRO (JP)
TARUMIZU YUTA (JP)
Application Number:
PCT/JP2022/032709
Publication Date:
March 09, 2023
Filing Date:
August 31, 2022
Export Citation:
Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
International Classes:
A61K47/68; A61K47/42; A61K51/10; A61P35/00; C07D403/12; C07K16/00
Domestic Patent References:
| WO2021075546A1 | 2021-04-22 | |||
| WO2017141604A1 | 2017-08-24 | |||
| WO2021075545A1 | 2021-04-22 | |||
| WO2016186206A1 | 2016-11-24 | |||
| WO2017217347A1 | 2017-12-21 | |||
| WO2018230257A1 | 2018-12-20 | |||
| WO2021080008A1 | 2021-04-29 |
Foreign References:
| JP2002512014A | 2002-04-23 | |||
| US20190389966A1 | 2019-12-26 | |||
| JP2021141625A | 2021-09-16 |
Other References:
VIVIER DELPHINE, SHARMA SAI KIRAN, ADUMEAU PIERRE, RODRIGUEZ CINDY, FUNG KIMBERLY, ZEGLIS BRIAN M.: "The Impact of FcγRI Binding on Immuno-PET", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 60, no. 8, 1 August 2019 (2019-08-01), US , pages 1174 - 1182, XP093042302, ISSN: 0161-5505, DOI: 10.2967/jnumed.118.223636
OKAZAKI A., ET AL: "Fucose Depletion from Human IgG1 Oligosaccharide Enhances Binding Enthalpy and Association Rate Between IgG1 and Fcgamma RIIIa", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 336, no. 5, 5 March 2004 (2004-03-05), United Kingdom , pages 1239 - 1249, XP002610113, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2004.01.007
VIVIER D. ET AL., J NUCL MED., vol. 60, no. 8, August 2019 (2019-08-01), pages 1174 - 1182
HAKIMUDDIN ET AL., ARCH. BIOCHEM. BIOPHYS., vol. 259, 1987, pages 52
EDGE ET AL., ANAL. BIOCHEM., vol. 118, 1981, pages 131
THOTAKURA ET AL., METH. ENZYMOL., vol. 138, 1987, pages 350
J. NUCL. MED., vol. 60, 2019, pages 1174
CHEM. EUR. J., vol. 18, 2012, pages 7834 - 7841
OKAZAKI A., ET AL: "Fucose Depletion from Human IgG1 Oligosaccharide Enhances Binding Enthalpy and Association Rate Between IgG1 and Fcgamma RIIIa", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 336, no. 5, 5 March 2004 (2004-03-05), United Kingdom , pages 1239 - 1249, XP002610113, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2004.01.007
VIVIER D. ET AL., J NUCL MED., vol. 60, no. 8, August 2019 (2019-08-01), pages 1174 - 1182
HAKIMUDDIN ET AL., ARCH. BIOCHEM. BIOPHYS., vol. 259, 1987, pages 52
EDGE ET AL., ANAL. BIOCHEM., vol. 118, 1981, pages 131
THOTAKURA ET AL., METH. ENZYMOL., vol. 138, 1987, pages 350
J. NUCL. MED., vol. 60, 2019, pages 1174
CHEM. EUR. J., vol. 18, 2012, pages 7834 - 7841
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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