Title:
RADIOACTIVE COMPOUND FOR TREATMENT OF MELANOMA AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/004785
Kind Code:
A1
Abstract:
The present invention relates to a radioactive compound with an improved ability to target melanoma, and a pharmaceutical composition for treating melanoma comprising same. Compared to conventional compositions for contrasting melanoma, the radioactive compound not only exhibits an improved ability to target melanoma, but is also very highly effective in treating melanoma through the use of therapeutic radionuclides.
Inventors:
MIN JUNG-JOON (KR)
KIM DONG-YEON (KR)
PYO A-YOUNG (KR)
KIM DONG-YEON (KR)
PYO A-YOUNG (KR)
Application Number:
PCT/KR2019/004396
Publication Date:
January 02, 2020
Filing Date:
April 11, 2019
Export Citation:
Assignee:
UNIV NAT CHONNAM IND FOUND (KR)
International Classes:
C07D213/53; A61K51/04; A61P35/00; C07F5/00; C07F9/58
Domestic Patent References:
| WO2018131911A1 | 2018-07-19 |
Foreign References:
| DE19519508A1 | 1996-12-05 | |||
| KR20180074766A | 2018-07-03 |
Other References:
PYO A YPUNG : "Synthesis and Evaluation of Radiolabeled Protein Binder and Benzamide Derivative for Imaging of Lung Cancer and Malignant Melanoma", THESIS, February 2017 (2017-02-01), pages 1 - 95, XP009525644
HONGGUANG LIU; LIU SHUANGLONG; MIAO ZHENG; DENG ZIXIN; SHEN BAOZHONG; HONG XUECHUAN; CHENG ZHEN: "Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 3, 9 January 2013 (2013-01-09), pages 895 - 901, XP055667650, ISSN: 0022-2623, DOI: 10.1021/jm301740k
EMILIE M F BILLAUD; AURÉLIEN VIDAL; AMÉLIE VINCENOT; SOPHIE BESSE; BERNADETTE BOUCHON; ERIC DEBITON; ELISABETH MIOT-NOIRAULT; IMEN: "Development and preliminary evaluation of TFIB, a new bimodal prosthetic group for bioactive molecule labeling", ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 2, 12 February 2015 (2015-02-12), pages 168 - 172, XP055517377, ISSN: 1948-5875, DOI: 10.1021/ml500423v
DITTMANN H; COENEN H H; ZOLZER F; DUTSCHKA K; BRANDAU W; STREFFER C: "In vitro studies on the cellular uptake of melanoma imaging aminoalkyl-iodobenzamide derivatives (ABA", NUCLEAR MEDICINE AND BIOLOGY, vol. 26, no. 1, 1 January 1999 (1999-01-01), pages 51 - 56, XP004151300, ISSN: 0969-8051, DOI: 10.1016/S0969-8051(98)00046-8
REN ET AL., J. NUCL. MED., vol. 50, no. 10, 2009, pages 1692 - 1699
See also references of EP 3816156A4
HONGGUANG LIU; LIU SHUANGLONG; MIAO ZHENG; DENG ZIXIN; SHEN BAOZHONG; HONG XUECHUAN; CHENG ZHEN: "Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 3, 9 January 2013 (2013-01-09), pages 895 - 901, XP055667650, ISSN: 0022-2623, DOI: 10.1021/jm301740k
EMILIE M F BILLAUD; AURÉLIEN VIDAL; AMÉLIE VINCENOT; SOPHIE BESSE; BERNADETTE BOUCHON; ERIC DEBITON; ELISABETH MIOT-NOIRAULT; IMEN: "Development and preliminary evaluation of TFIB, a new bimodal prosthetic group for bioactive molecule labeling", ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 2, 12 February 2015 (2015-02-12), pages 168 - 172, XP055517377, ISSN: 1948-5875, DOI: 10.1021/ml500423v
DITTMANN H; COENEN H H; ZOLZER F; DUTSCHKA K; BRANDAU W; STREFFER C: "In vitro studies on the cellular uptake of melanoma imaging aminoalkyl-iodobenzamide derivatives (ABA", NUCLEAR MEDICINE AND BIOLOGY, vol. 26, no. 1, 1 January 1999 (1999-01-01), pages 51 - 56, XP004151300, ISSN: 0969-8051, DOI: 10.1016/S0969-8051(98)00046-8
REN ET AL., J. NUCL. MED., vol. 50, no. 10, 2009, pages 1692 - 1699
See also references of EP 3816156A4
Attorney, Agent or Firm:
HAN, Yun Ho (KR)
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