Title:
RADIOACTIVE ISOTOPE-LABELED, PHOTO-CROSSLINKABLE HYDROGEL AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/159080
Kind Code:
A1
Abstract:
The present invention provides a photo-crosslinkable hydrogel and a preparation method therefor. The hydrogel may comprise a radioactive isotope-labeled photo-crosslinkable compound or a pharmaceutically acceptable salt thereof and can be used as a radiotherapeutic composition, a radio diagnostic imaging composition, and an anticancer therapeutic composition. The hydrogel is highly localized and stays in a site requiring radiotherapy, and as such can treat diseases such as cancer and the like, with minimal damage to surrounding tissues. In addition, the hydrogel can be used as a pharmaceutical composition for treatment of cancer in combination with an anticancer agent and thus can effectively treat cancer. The hydrogel according to the present invention can be fabricated with a portable microfluidic system, immediately, rapidly, and conveniently on site, whereby a maximal radiotherapeutic effect can be achieved.
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Inventors:
YANG SEUNG YUN (KR)
KIM SODAM (KR)
YIM SANG-GU (KR)
KUMAR SUJEET (KR)
CHANDRASEKHARAN AJEESH (KR)
KIM SODAM (KR)
YIM SANG-GU (KR)
KUMAR SUJEET (KR)
CHANDRASEKHARAN AJEESH (KR)
Application Number:
PCT/KR2019/018094
Publication Date:
August 06, 2020
Filing Date:
December 19, 2019
Export Citation:
Assignee:
PUSAN NATIONAL UNIV INDUSTRY-UNIV COOPERATION FOUNDATION (KR)
International Classes:
C08B37/08; A61K9/06; A61K45/06; A61K51/12; C08J3/07; A61P35/00
Other References:
MESSAGER, L. ET AL.: "Photochemical crosslinking of hyaluronic acid confined in nanoemulsions: towards nanogels with a controlled structure", JOURNAL OF MATERIALS CHEMISTRY B, vol. 1, no. 27, 2013, pages 3369 - 3379, XP055588559, DOI: 10.1039/c3tb20300j
HUANG, P. ET AL.: "Co-delivery of doxorubicin and 1311 by thermosensitive micellar-hydrogel for enhanced in situ synergetic chemoradiotherapy", JOURNAL OF CONTROLLED RELEASE, vol. 220, 10 November 2015 (2015-11-10), pages 456 - 464, XP029341161
BUSATTO, C. A. ET AL.: "Oil -in-microgel strategy for enzymatic-triggered release of hydrophobic drugs", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 493, 10 January 2017 (2017-01-10), pages 356 - 364, XP029905170, DOI: 10.1016/j.jcis.2017.01.029
CAMCI-UNAL, G. ET AL.: "Surface-modified hyaluronic acid hydrogels to capture endothelial progenitor cells", SOFT MATTER, vol. 6, no. 20, 2010, pages 5120 - 5126, XP055726124
MA, Y. ET AL.: "Biocompatible macro-initiators controlling radical retention in microfluidic on-chip photo-polymerization of water-in-oil emulsions", CHEMICAL COMMUNICATIONS, vol. 50, no. 1, 2014, pages 112 - 114, XP055718909, DOI: 10.1039/C3CC46733C
FENN, S. L. ET AL.: "Visible light crosslinking of methacrylated hyaluronan hydrogels for injectable tissue repair", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS, vol. 104, no. 6, August 2016 (2016-08-01), pages 229 - 1236, XP055726127
See also references of EP 3919521A4
HUANG, P. ET AL.: "Co-delivery of doxorubicin and 1311 by thermosensitive micellar-hydrogel for enhanced in situ synergetic chemoradiotherapy", JOURNAL OF CONTROLLED RELEASE, vol. 220, 10 November 2015 (2015-11-10), pages 456 - 464, XP029341161
BUSATTO, C. A. ET AL.: "Oil -in-microgel strategy for enzymatic-triggered release of hydrophobic drugs", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 493, 10 January 2017 (2017-01-10), pages 356 - 364, XP029905170, DOI: 10.1016/j.jcis.2017.01.029
CAMCI-UNAL, G. ET AL.: "Surface-modified hyaluronic acid hydrogels to capture endothelial progenitor cells", SOFT MATTER, vol. 6, no. 20, 2010, pages 5120 - 5126, XP055726124
MA, Y. ET AL.: "Biocompatible macro-initiators controlling radical retention in microfluidic on-chip photo-polymerization of water-in-oil emulsions", CHEMICAL COMMUNICATIONS, vol. 50, no. 1, 2014, pages 112 - 114, XP055718909, DOI: 10.1039/C3CC46733C
FENN, S. L. ET AL.: "Visible light crosslinking of methacrylated hyaluronan hydrogels for injectable tissue repair", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS, vol. 104, no. 6, August 2016 (2016-08-01), pages 229 - 1236, XP055726127
See also references of EP 3919521A4
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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