Title:
RADIOACTIVE MOLECULAR PROBE AND APPLICATION THEREOF IN DETECTION OF INTRAVITAL ISLETS
Document Type and Number:
WIPO Patent Application WO/2019/169815
Kind Code:
A1
Abstract:
A radioactive molecular probe and an application thereof in detection of intravital islets, its structure is: formula (I), wherein R 1 are halogen, saturated aliphatic hydrocarbon group, unsaturated aliphatic hydrocarbon group and aromatic hydrocarbon group; R 2 are halogen, saturated aliphatic hydrocarbon group, unsaturated aliphatic hydrocarbon group and aromatic hydrocarbon group; R 3 are hydrogen, saturated aliphatic hydrocarbon group, unsaturated aliphatic hydrocarbon group and aromatic hydrocarbon group; R 4 are hydrogen, saturated aliphatic hydrocarbon group, unsaturated aliphatic hydrocarbon group and aromatic hydrocarbon group; R 5 are hydrogen, saturated aliphatic hydrocarbon group, unsaturated aliphatic hydrocarbon group and aromatic hydrocarbon group; R 6 are hydrogen and deuterium; R 7 are hydrogen and deuterium; the radioactive molecular probe can perform intravital islet imaging and assessment of the number of intravital islets.
Inventors:
LIU ZHIBO (CN)
HAN YUXIANG (CN)
HAN YUXIANG (CN)
Application Number:
PCT/CN2018/094812
Publication Date:
September 12, 2019
Filing Date:
July 06, 2018
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
C07F5/02; A61B5/00; A61K51/04; C07B59/00; A61K101/02
Domestic Patent References:
| WO2016176572A1 | 2016-11-03 |
Foreign References:
| CN105377859A | 2016-03-02 | |||
| CN103189388A | 2013-07-03 |
Other References:
ZHIBO LIU: "An Organotrifluoroborate for Broadly Applicable One - Step 18F - Labeling", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 53, no. 44, 4 September 2014 (2014-09-04), pages 11876 - 11880, XP055305191
Attorney, Agent or Firm:
BEIJING CHEN QUAN INTELLECTUAL PROPERTY LAW FIRM (CN)
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