Title:
RADIOLABELED COMPOUND PRODUCTION METHOD AND PRODUCTION DEVICE, RADIO-LABELED COMPOUND, AND RADIOISOTOPE PRODUCTION DEVICE
Document Type and Number:
WIPO Patent Application WO/2020/202726
Kind Code:
A1
Abstract:
The present invention solves the problem of providing a technique allowing a novel radiolabeled compound to be produced. The present invention is a radio-labeled compound production method comprising: a step of irradiating a radiation beam onto a target substance alloy, thereby causing two or more species of radioisotope to be generated from the alloy and transferred into a gas; a step of causing, among the two or more species of radioisotope transferred into the gas, a first radioisotope species to react with a labeling precursor and generate an intermediate labeled body; and a step of causing, among the two or more species of radioisotope transferred into the gas, a second radioisotope species, which is different from the first radioisotope species, to react with the intermediate labeled body and generate a final labeled body.
Inventors:
ISHIOKA NORIKO (JP)
KONDO HIROO (JP)
WATANABE SHIGEKI (JP)
KONDO HIROO (JP)
WATANABE SHIGEKI (JP)
Application Number:
PCT/JP2020/002329
Publication Date:
October 08, 2020
Filing Date:
January 23, 2020
Export Citation:
Assignee:
NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECH (JP)
International Classes:
A61P35/00; A61K51/02; C07K1/13; G21G1/10
Domestic Patent References:
| WO2017183697A1 | 2017-10-26 | |||
| WO2012039038A1 | 2012-03-29 |
Foreign References:
| JP2014530898A | 2014-11-20 | |||
| JP2013511046A | 2013-03-28 | |||
| JP2018502054A | 2018-01-25 | |||
| JP2014196997A | 2014-10-16 | |||
| US20150079000A1 | 2015-03-19 | |||
| JP2015147767A | 2015-08-20 |
Other References:
Y. TALL ET AL.: "Volatile elements production rates in a protonirradiated molten lead-bismuth target", INTERNATIONAL CONFERENCE ON NUCLEAR DATA FOR SCIENCE AND TECHNOLOGY 2007, 1 January 2007 (2007-01-01), pages 1069 - 1072, XP055612223
T G TURKINGTON ET AL.: "Measuring astatine-211 distributions with SPECT", PHYS. MED. BIOL., vol. 38, 1993, pages 1121 - 1130
YUTO NAGAO ET AL.: "Astatine-211 imaging by a Compton camera for targeted radiotherapy", APPLIED RADIATION AND ISOTOPES, vol. 139, 2018, pages 238 - 243
D. SCOTT WILBUR ET AL.: "Reagents for Astatination of Biomolecules. 2. Conjugation of Anionic Boron Cage Pendant Groups to a Protein Provides a Method for Direct Labeling that is Stable to in Vivo Deastatination", BIOCONJUGATE CHEM, vol. 18, 2007, pages 1226 - 1240
T G TURKINGTON ET AL.: "Measuring astatine-211 distributions with SPECT", PHYS. MED. BIOL., vol. 38, 1993, pages 1121 - 1130
YUTO NAGAO ET AL.: "Astatine-211 imaging by a Compton camera for targeted radiotherapy", APPLIED RADIATION AND ISOTOPES, vol. 139, 2018, pages 238 - 243
D. SCOTT WILBUR ET AL.: "Reagents for Astatination of Biomolecules. 2. Conjugation of Anionic Boron Cage Pendant Groups to a Protein Provides a Method for Direct Labeling that is Stable to in Vivo Deastatination", BIOCONJUGATE CHEM, vol. 18, 2007, pages 1226 - 1240
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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