Title:
RADIOLABELED DRUG
Document Type and Number:
WIPO Patent Application WO/2017/150549
Kind Code:
A1
Abstract:
The present invention pertains to a compound, etc., from which is obtained a radiolabeled drug capable of reducing accumulation in the kidneys from early administration. [1] A compound, etc., represented by formula (1); [2] a compound, etc., obtained by bonding a target molecule recognition element to the compound, etc., described in [1] above; [3] a metal complex compound, etc., having one type of metal selected from radioactive metals and radioactive atom-labeled metals, and the compound, etc., described in [1] or [2] above coordinated to the metal; [4] a drug for preparing a radiolabeled drug including the compound, etc., described in [1] or [2] above; [5] a use for producing a radiolabeled drug of the compound, etc., described in [1] or [2] above; [6] a radiolabeled drug including the metal complex compound, etc., described in [3] above; and [7] a radiologic imaging diagnostic agent including the metal complex, etc., described in [3] above.
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Inventors:
ARANO YASUSHI (JP)
UEHARA TOMOYA (JP)
UEHARA TOMOYA (JP)
Application Number:
PCT/JP2017/007875
Publication Date:
September 08, 2017
Filing Date:
February 28, 2017
Export Citation:
Assignee:
NAT UNIV CORP CHIBA UNIV (JP)
International Classes:
C07K5/08; A61K51/08; A61K51/10; C07K19/00
Domestic Patent References:
| WO2013081091A1 | 2013-06-06 |
Other References:
UEHARA T. ET AL.: "67/68Ga-labeling agent that liberates 67/68Ga-NOTA-methionine by lysosomal proteolysis of parental low molecular weight polypeptides to reduce renal radioactivity levels", BIOCONJUGATE CHEM., vol. 25, no. 11, 19 November 2014 (2014-11-19), pages 2038 - 2045, XP055312995
AKIZAWA H. ET AL.: "Renal uptake and metabolism of radiopharmaceuticals derived from peptides and proteins", ADV. DRUG DELIV. REV., vol. 60, no. 12, 2008, pages 1319 - 1328, XP022851262
UEHARA ET AL.: "Hoshasei Gallium Hyoshiki Kotai Fragment no Hi Tokuiteki Jin Shuseki o Teigen saseru Hyoshiki Yakuzai no Kaihatsu", ABSTRACTS OF 136TH ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN; 26-29/03/2016; YOKOHAMA, JAPAN, vol. 136, 4 March 2016 (2016-03-04), pages 27L-am01 , XP009515147
TOMOYA UEHARA: "Radio-gallium labeling reagent for antibody fragments with low renal radioactivity levels", ANNUAL SCIENCTIFIC MEETING OF THE JAPANESE SOCIETY OF NUCLEAR MEDICINE YOSHISHU, 20 October 2016 (2016-10-20), pages S266, XP009515362, DOI: 10.18893/kakuigaku.53.S123
BIOCONJUGATE CHEM., vol. 25, 2014, pages 2038 - 2045
ANALYTICAL BIOCHEMISTRY, vol. 34, 1970, pages 595 - 598
JOURNAL OF ORGANIC CHEMISTRY, vol. 69, 2004, pages 4586 - 4594
ANALYTICAL BIOCHEMISTRY, vol. 142, 1984, pages 68 - 78
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 119, 1967, pages 41 - 49
BIOCONJUGATE CHEM., vol. 8, 1997, pages 365 - 369
See also references of EP 3424940A4
AKIZAWA H. ET AL.: "Renal uptake and metabolism of radiopharmaceuticals derived from peptides and proteins", ADV. DRUG DELIV. REV., vol. 60, no. 12, 2008, pages 1319 - 1328, XP022851262
UEHARA ET AL.: "Hoshasei Gallium Hyoshiki Kotai Fragment no Hi Tokuiteki Jin Shuseki o Teigen saseru Hyoshiki Yakuzai no Kaihatsu", ABSTRACTS OF 136TH ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN; 26-29/03/2016; YOKOHAMA, JAPAN, vol. 136, 4 March 2016 (2016-03-04), pages 27L-am01 , XP009515147
TOMOYA UEHARA: "Radio-gallium labeling reagent for antibody fragments with low renal radioactivity levels", ANNUAL SCIENCTIFIC MEETING OF THE JAPANESE SOCIETY OF NUCLEAR MEDICINE YOSHISHU, 20 October 2016 (2016-10-20), pages S266, XP009515362, DOI: 10.18893/kakuigaku.53.S123
BIOCONJUGATE CHEM., vol. 25, 2014, pages 2038 - 2045
ANALYTICAL BIOCHEMISTRY, vol. 34, 1970, pages 595 - 598
JOURNAL OF ORGANIC CHEMISTRY, vol. 69, 2004, pages 4586 - 4594
ANALYTICAL BIOCHEMISTRY, vol. 142, 1984, pages 68 - 78
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 119, 1967, pages 41 - 49
BIOCONJUGATE CHEM., vol. 8, 1997, pages 365 - 369
See also references of EP 3424940A4
Attorney, Agent or Firm:
HIRASAWA, Kenichi et al. (JP)
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