Title:
RADIOLABELED TYROSINE DERIVATIVE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/063095
Kind Code:
A1
Abstract:
The prevent invention provides a radiolabeled tyrosine derivative which has excellent LAT1 selectability, higher retention at a tumor or cancer site, and a degree of clearance that does not cause side effects, and which can be safely manufactured at favorable purity by a safe method suitable for industrial production. The present invention provides a radiolabeled compound represented by formula (I), or a pharmaceutically-acceptable salt thereof. [In the formula, each symbol is as defined in the description.]
Inventors:
KANEDA KAZUKO (JP)
SHIRAKAMI YOSHIFUMI (JP)
KADONAGA YUICHIRO (JP)
TOYOSHIMA ATSUSHI (JP)
FUKASE KOICHI (JP)
NAGATA HIROSHI (JP)
SHIRAKAMI YOSHIFUMI (JP)
KADONAGA YUICHIRO (JP)
TOYOSHIMA ATSUSHI (JP)
FUKASE KOICHI (JP)
NAGATA HIROSHI (JP)
Application Number:
PCT/JP2023/034114
Publication Date:
March 28, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C07C229/34; A61K41/00; A61K51/04; A61P35/00; A61P35/02; C07B59/00; C07F5/02
Domestic Patent References:
WO2021225147A1 | 2021-11-11 | |||
WO2019027059A1 | 2019-02-07 |
Foreign References:
JP2000212185A | 2000-08-02 |
Other References:
KRUMMEICH, C. ; HOLSCHBACH, M. ; STOCKLIN, G.: "Direct n.c.a. electrophilic radioiodination of tyrosine analogues; their in vivo stability and brain-uptake in mice", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD., GB, vol. 45, no. 9, 1 September 1994 (1994-09-01), GB , pages 929 - 935, XP024685318, ISSN: 0969-8043, DOI: 10.1016/0969-8043(94)90230-5
KRUMMEICH, C. HOLSCHBACH, M.: "Kit Preparation of n.c.a. 3-[^1^2^3I]Iodo-l-@a-methyltyrosine [^1^2^3I]IMT, 3-[^1^2^3I]Iodo-O-methyl-l-tyrosine [^1^2^3I]OMIT and 3-[^1^2^3I]Iodo-O-methyl-l-@a-methyltyrosine [^1^2^3I]OMIMT Using Sep-Pak^T^M C-18 Cartridges", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD., GB, vol. 46, no. 9, 1 September 1995 (1995-09-01), GB , pages 917 - 921, XP004050703, ISSN: 0969-8043, DOI: 10.1016/0969-8043(95)93109-Y
HIGASHI TATSUYA: "Novel radioisotope therapies for thyroid cancers: a future perspective", JOURNAL OF THE JAPANESE SOCIETY OF ENDOCRINE AND THYROID SURGERY, vol. 35, no. 3, 1 January 2018 (2018-01-01), pages 196 - 199, XP093149927
WIRIYASERMKUL PATTAMA, MORIYAMA SATOMI, KONGPRACHA PORNPARN, NAGAMORI SHUSHI: "Drug Discovery Targeting an Amino Acid Transporter for Diagnosis and Therapy", YAKUGAKU ZASSHI, vol. 141, no. 4, 31 August 2020 (2020-08-31), pages 501 - 510, XP093057908, DOI: 10.1248/yakushi.20-00204-2
KRUMMEICH, C. HOLSCHBACH, M.: "Kit Preparation of n.c.a. 3-[^1^2^3I]Iodo-l-@a-methyltyrosine [^1^2^3I]IMT, 3-[^1^2^3I]Iodo-O-methyl-l-tyrosine [^1^2^3I]OMIT and 3-[^1^2^3I]Iodo-O-methyl-l-@a-methyltyrosine [^1^2^3I]OMIMT Using Sep-Pak^T^M C-18 Cartridges", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD., GB, vol. 46, no. 9, 1 September 1995 (1995-09-01), GB , pages 917 - 921, XP004050703, ISSN: 0969-8043, DOI: 10.1016/0969-8043(95)93109-Y
HIGASHI TATSUYA: "Novel radioisotope therapies for thyroid cancers: a future perspective", JOURNAL OF THE JAPANESE SOCIETY OF ENDOCRINE AND THYROID SURGERY, vol. 35, no. 3, 1 January 2018 (2018-01-01), pages 196 - 199, XP093149927
WIRIYASERMKUL PATTAMA, MORIYAMA SATOMI, KONGPRACHA PORNPARN, NAGAMORI SHUSHI: "Drug Discovery Targeting an Amino Acid Transporter for Diagnosis and Therapy", YAKUGAKU ZASSHI, vol. 141, no. 4, 31 August 2020 (2020-08-31), pages 501 - 510, XP093057908, DOI: 10.1248/yakushi.20-00204-2
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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