Title:
RADIOPHARMACEUTICALS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/147338
Kind Code:
A3
Abstract:
Targeted pharmaceuticals, particularly targeted radiopharmaceuticals, are provided which possess extended tumor retention time. In certain embodiments, the pharmaceuticals comprise a) a targeting moiety, b) a cysteine cathepsin trapping agent (CCTA), and c) a cytotoxic or radioactive moiety. Also provided are methods of inhibiting or treating a disease or disorder (e.g., cancer) in a subject in need thereof, comprising administering a pharmaceutical compound of the instant invention to the subject.
Inventors:
GARRISON JERED (US)
FAN WEI (US)
ZHANG WENTING (US)
FAN WEI (US)
ZHANG WENTING (US)
Application Number:
PCT/US2018/062781
Publication Date:
November 07, 2019
Filing Date:
November 28, 2018
Export Citation:
Assignee:
UNIV NEBRASKA (US)
International Classes:
A61K47/64; A61K47/68
Domestic Patent References:
| WO2016077505A2 | 2016-05-19 |
Foreign References:
| US20170119913A1 | 2017-05-04 | |||
| US20100256055A1 | 2010-10-07 | |||
| US20170319643A1 | 2017-11-09 | |||
| US20140227175A1 | 2014-08-14 |
Other References:
FAN ET AL.: "Increasing time on target: utilization of inhibitors of cysteine cathepsins to enhance the tumor retention of receptor-targeted agents", CHEMICAL COMMUNICATIONS, vol. 54, no. 80, 4 October 2018 (2018-10-04), pages 11268 - 11271, XP055650672, DOI: 10.1039/C8CC05982A
Attorney, Agent or Firm:
NETTER, Robert, C., Jr. et al. (US)
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