Title:
RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/111278
Kind Code:
A3
Abstract:
Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Inventors:
AHRENDT KATERI A (US)
BUCKMELTER ALEXANDRE J (US)
GRINA JONAS (US)
HANSEN JOSHUA D (US)
LAIRD ELLEN R (US)
MORENO DAVID (US)
NEWHOUSE BRAD (US)
REN LI (US)
WENGLOWSKY STEVEN MARK (US)
FENG BAINIAN (US)
GUNZNER JANET (US)
MALESKY KIM (US)
MATHIEU SIMON (US)
RUDOLPH JOACHIM (US)
WEN ZHAOYANG (US)
YOUNG WENDY B (US)
BUCKMELTER ALEXANDRE J (US)
GRINA JONAS (US)
HANSEN JOSHUA D (US)
LAIRD ELLEN R (US)
MORENO DAVID (US)
NEWHOUSE BRAD (US)
REN LI (US)
WENGLOWSKY STEVEN MARK (US)
FENG BAINIAN (US)
GUNZNER JANET (US)
MALESKY KIM (US)
MATHIEU SIMON (US)
RUDOLPH JOACHIM (US)
WEN ZHAOYANG (US)
YOUNG WENDY B (US)
Application Number:
PCT/US2009/035380
Publication Date:
July 15, 2010
Filing Date:
February 27, 2009
Export Citation:
Assignee:
ARRAY BIOPHARMA INC (US)
GENENTECH INC (US)
AHRENDT KATERI A (US)
BUCKMELTER ALEXANDRE J (US)
GRINA JONAS (US)
HANSEN JOSHUA D (US)
LAIRD ELLEN R (US)
MORENO DAVID (US)
NEWHOUSE BRAD (US)
REN LI (US)
WENGLOWSKY STEVEN MARK (US)
FENG BAINIAN (US)
GUNZNER JANET (US)
MALESKY KIM (US)
MATHIEU SIMON (US)
RUDOLPH JOACHIM (US)
WEN ZHAOYANG (US)
YOUNG WENDY B (US)
GENENTECH INC (US)
AHRENDT KATERI A (US)
BUCKMELTER ALEXANDRE J (US)
GRINA JONAS (US)
HANSEN JOSHUA D (US)
LAIRD ELLEN R (US)
MORENO DAVID (US)
NEWHOUSE BRAD (US)
REN LI (US)
WENGLOWSKY STEVEN MARK (US)
FENG BAINIAN (US)
GUNZNER JANET (US)
MALESKY KIM (US)
MATHIEU SIMON (US)
RUDOLPH JOACHIM (US)
WEN ZHAOYANG (US)
YOUNG WENDY B (US)
International Classes:
A61K31/437; C07D471/04; A61P35/00; C07C311/08
Domestic Patent References:
| WO2001098299A1 | 2001-12-27 | |||
| WO2005030709A1 | 2005-04-07 | |||
| WO2004054974A2 | 2004-07-01 | |||
| WO2009012283A1 | 2009-01-22 |
Foreign References:
| DE2803651A1 | 1978-08-03 |
Other References:
YAGUPOL'SKII L M ET AL: "N,N-Bis(trifluoromethylsulfonyl)arylamines and .sigma.-constants of the bis(trifluoromethylsulfonyl)amino group", ZHURNAL ORGANICHESKOI KHIMII, MAIK NAUKA, MOSCOW, RU, vol. 10, no. 4, 1 January 1974 (1974-01-01), pages 889 - 890, XP009123034, ISSN: 0514-7492
PERZANOWSKI HERMAN P ET AL: "Carbon-13 and nitrogen-15 NMR spectral study of some dimethanesulfonanilides", CANADIAN JOURNAL OF ANALYTICAL SCIENCES AND SPECTROSCOPY, A, MORIN HEIGHTS, vol. 42, no. 1, 1 January 1997 (1997-01-01), pages 18 - 22, XP009123033, ISSN: 1205-6685
PERZANOWSKI HERMAN P ET AL: "Carbon-13 and nitrogen-15 NMR spectral study of some dimethanesulfonanilides", CANADIAN JOURNAL OF ANALYTICAL SCIENCES AND SPECTROSCOPY, A, MORIN HEIGHTS, vol. 42, no. 1, 1 January 1997 (1997-01-01), pages 18 - 22, XP009123033, ISSN: 1205-6685
Attorney, Agent or Firm:
HARRIS, Robert J. et al. (Saint Paul, Minnesota, US)
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