Title:
RALDH2 EXPRESSION ENHANCING AGENT
Document Type and Number:
WIPO Patent Application WO/2022/075096
Kind Code:
A1
Abstract:
Provided is a novel RALDH2 expression enhancing agent. The present invention provides a RALDH2 expression enhancing agent containing, as an active ingredient, one or a plurality of components selected from the group consisting of quercetin, kaempferol, adlay, bee pollen, Polygonatum falcatum, hop, Citrus unshiu peel, cabbage, celery, okra, parsley, asparagus, Angelica keiskei, clove, barley grass, Houttuynia cordata, baobab fruit, broccoli, moringa, Plantago asiatica, Lycium chinense berry, Aloe arborescens, maca, and olive leaf.
Inventors:
SHIRAI YUMI (JP)
KATAKURA YOSHINORI (JP)
KON TATSUYA (JP)
KATAKURA YOSHINORI (JP)
KON TATSUYA (JP)
Application Number:
PCT/JP2021/035162
Publication Date:
April 14, 2022
Filing Date:
September 24, 2021
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
International Classes:
A61K31/353; A61K35/644; A61K36/185; A61K36/23; A61K36/232; A61K36/31; A61K36/48; A61K36/63; A61K36/752; A61K36/78; A61K36/815; A61K36/886; A61K36/8969; A61K36/8994; A61K36/8998; A61P17/00; A61P37/02; A61P37/08; A61P43/00
Domestic Patent References:
| WO2011093469A1 | 2011-08-04 | |||
| WO2015137501A1 | 2015-09-17 |
Foreign References:
| JP2004075619A | 2004-03-11 |
Other References:
MICHALSKI JULIA; DEINZER ANDREA; STICH LENA; ZINSER ELISABETH; STEINKASSERER ALEXANDER; KNIPPERTZ ILKA: "Quercetin induces an immunoregulatory phenotype in maturing human dendritic cells", IMMUNOBIOLOGY, vol. 225, no. 4, 24 February 2020 (2020-02-24), DE , pages 1 - 12, XP086233904, ISSN: 0171-2985, DOI: 10.1016/j.imbio.2020.151929
YANG YAN; ZHANG XU; XU MIN; WU XIN; ZHAO FEIPENG; ZHAO CHENGZHI: "Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 54, 14 November 2017 (2017-11-14), NL , pages 153 - 162, XP085303015, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2017.11.013
WEI CAI-BING, TAO KUN, JIANG RONG, ZHOU LIAN-DI, ZHANG QI-HUI, YUAN CHUN-SU: "Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-κB pathway", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 53, 1 December 2017 (2017-12-01), NL , pages 73 - 82, XP055920514, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2017.09.026
HUANG REN-YEONG, YU YEN-LING, CHENG WAN-CHIEN, OUYANG CHUN-NAN, FU EARL, CHU CHING-LIANG: "Immunosuppressive Effect of Quercetin on Dendritic Cell Activation and Function", THE JOURNAL OF IMMUNOLOGY, vol. 184, no. 12, 15 June 2010 (2010-06-15), US , pages 6815 - 6821, XP055920526, ISSN: 0022-1767, DOI: 10.4049/jimmunol.0903991
MARTÍNEZ GRICELIS, MIJARES MICHAEL R., DE SANCTIS JUAN B.: "Effects of Flavonoids and Its Derivatives on Immune Cell Responses", RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY, vol. 13, no. 2, 4 December 2019 (2019-12-04), NL , pages 84 - 104, XP055920530, ISSN: 1872-213X, DOI: 10.2174/1872213X13666190426164124
WANG RONG, YANG LAIXIU, LI SHEN, YE DONGMEI, YANG LIHONG, LIU QINGYAN, ZHAO ZIBO, CAI QING, TAN JUNZHEN, LI XIULI: "Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)", MEDICAL SCIENCE MONITOR, vol. 24, 1 January 2018 (2018-01-01), pages 412 - 420, XP055920533, DOI: 10.12659/MSM.908022
YANG YAN; ZHANG XU; XU MIN; WU XIN; ZHAO FEIPENG; ZHAO CHENGZHI: "Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 54, 14 November 2017 (2017-11-14), NL , pages 153 - 162, XP085303015, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2017.11.013
WEI CAI-BING, TAO KUN, JIANG RONG, ZHOU LIAN-DI, ZHANG QI-HUI, YUAN CHUN-SU: "Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-κB pathway", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 53, 1 December 2017 (2017-12-01), NL , pages 73 - 82, XP055920514, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2017.09.026
HUANG REN-YEONG, YU YEN-LING, CHENG WAN-CHIEN, OUYANG CHUN-NAN, FU EARL, CHU CHING-LIANG: "Immunosuppressive Effect of Quercetin on Dendritic Cell Activation and Function", THE JOURNAL OF IMMUNOLOGY, vol. 184, no. 12, 15 June 2010 (2010-06-15), US , pages 6815 - 6821, XP055920526, ISSN: 0022-1767, DOI: 10.4049/jimmunol.0903991
MARTÍNEZ GRICELIS, MIJARES MICHAEL R., DE SANCTIS JUAN B.: "Effects of Flavonoids and Its Derivatives on Immune Cell Responses", RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY, vol. 13, no. 2, 4 December 2019 (2019-12-04), NL , pages 84 - 104, XP055920530, ISSN: 1872-213X, DOI: 10.2174/1872213X13666190426164124
WANG RONG, YANG LAIXIU, LI SHEN, YE DONGMEI, YANG LIHONG, LIU QINGYAN, ZHAO ZIBO, CAI QING, TAN JUNZHEN, LI XIULI: "Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)", MEDICAL SCIENCE MONITOR, vol. 24, 1 January 2018 (2018-01-01), pages 412 - 420, XP055920533, DOI: 10.12659/MSM.908022
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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