Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
RAPAMYCIN ANALOGUES AND THEIR PHARMACEUTICAL USE
Document Type and Number:
WIPO Patent Application WO/2015/004455
Kind Code:
A3
Abstract:
Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

Inventors:
GREGORY MATTHEW ALAN (GB)
KENDREW STEVEN GARY (GB)
MOSS STEVEN JAMES (GB)
WILKINSON BARRIE (GB)
Application Number:
PCT/GB2014/052091
Publication Date:
March 12, 2015
Filing Date:
July 09, 2014
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
ISOMERASE THERAPEUTICS LTD (GB)
International Classes:
A01N43/90; C07D498/18; A61K31/439; A61P31/00; C12P17/18
Domestic Patent References:
WO2000009109A22000-02-24
Other References:
NELSON F C ET AL: "Manipulation of the C922)-C(27) region of rapamycin: stability issues and biological implications", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 9, no. 2, 18 January 1999 (1999-01-18), pages 295 - 300, XP004152620, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(98)00735-5
FRANCES C. NELSON ET AL: "A novel ring contraction of rapamycin", TETRAHEDRON LETTERS, vol. 35, no. 41, 1994, pages 7557 - 7560, XP055104826, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)78342-0
J. S. SKOTNICKI ET AL.: "Ring expanded rapamycin derivatives", TETRAHEDRON LETTERS, vol. 35, no. 2, 1994, pages 201 - 202, XP002730496
HOLT D A ET AL: "STRUCTURE-ACTIVITY STUDIES OF NONMACROCYCLIC RAPAMYCIN DERIVATIVES", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 3, no. 10, 1993, pages 1977 - 1980, XP000852549, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(01)80998-7
Attorney, Agent or Firm:
TEUTEN, Andrew et al. (Three GlobesideFieldhouse Lane,Marlow, Buckinghamshire SL7 1HZ, GB)
Download PDF: