Title:
RAPAMYCIN DERIVATIVES AND THE USES THEREOF IN THE TREATMENT OF NEUROLOGICAL DISORDERS
Document Type and Number:
WIPO Patent Application WO2006068905
Kind Code:
A3
Abstract:
The present invention provides compounds of the following structure, wherein R1-R9, R15, and n are defined herein. These compounds are useful in treating neurological disorders or complications due to stroke or head injury, and as neuroprotective and neuroregenerative agents.
Inventors:
GRAZIANI EDMUND IDRIS (US)
PONG KEVIN (US)
SKOTNICKI JERAULD (US)
PONG KEVIN (US)
SKOTNICKI JERAULD (US)
Application Number:
PCT/US2005/045331
Publication Date:
December 07, 2006
Filing Date:
December 15, 2005
Export Citation:
Assignee:
WYETH CORP (US)
GRAZIANI EDMUND IDRIS (US)
PONG KEVIN (US)
SKOTNICKI JERAULD (US)
GRAZIANI EDMUND IDRIS (US)
PONG KEVIN (US)
SKOTNICKI JERAULD (US)
International Classes:
C07D498/18; A61K31/435
Domestic Patent References:
| WO1996040140A1 | 1996-12-19 |
Foreign References:
| US20040224394A1 | 2004-11-11 |
Other References:
DENNIS A. HOLT ET AL.: "Structure Activity Studies of Synthetic FKBP ligands as Peptidyl-Prolyl Isomerase Inhibitors", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 2, 1994, pages 315 - 320, XP002391457
S.H. SNYDER AND D. M. SABATINI: "Immunophilins and the nervous system", NATURE MEDICINE, vol. 1, no. 1, 1995, pages 32 - 37, XP002391458
S.H. SNYDER AND D. M. SABATINI: "Immunophilins and the nervous system", NATURE MEDICINE, vol. 1, no. 1, 1995, pages 32 - 37, XP002391458
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